Results 131 to 140 of about 50,915 (302)

Divergent Hepatic Outcomes of Chronic Ketone Supplementation: Ketone Salts Preserve Liver Health While Ketone Esters and Precursors Drive Inflammation and Steatosis

open access: yesPharmaceuticals
Background/Objectives: Exogenous ketone supplements elevate circulating ketones without carbohydrate restriction, but their long-term hepatic safety remains unclear.
Csilla Ari, Dominic P. D’Agostino
doaj   +1 more source

The effect of thirteen plants on arginase , creatine kinase, amylase and lipase activities of the serum in diabetic rats [PDF]

open access: yesJournal of Kerman University of Medical Sciences, 1995
Many traditional plants are used for treatment of diabetes throughout the world as adjuncts to conventional therapy. The purpose of this study was  evaluate the effects of thirteen different plants on arginase, creatin kinase, amylase and lipase ...
M Saeb   +3 more
doaj  

Macronutrient and micronutrient profiles of meat types: insights into human health and diet

open access: yesJournal of the Science of Food and Agriculture, EarlyView.
Abstract Despite considerable advances in global health and nutrition, emerging challenges such as population growth, climate change, and limited natural resources continue to threaten food security. Meat remains an essential component of the human diet, supplying high‐quality proteins, essential amino acids, lipids, vitamins, and minerals necessary ...
Özgül Anitaş   +4 more
wiley   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

open access: yesNeuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi   +5 more
wiley   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

open access: yesPrenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde   +4 more
wiley   +1 more source

ФЕРМЕНТАТИВНАЯ АКТИВНОСТЬ ПЕЧЕНИ КРУПНОГО РОГАТОГО СКОТА ПРИ ФАСЦИОЛЕЗЕ

open access: yesВетеринарная патология, 2011
The aim of our research was to study the functioning of the enzyme system processes transamination, urea, antioxidant defense in the liver of cattle afflicted with fascioliasis, to determine the host-parasite relationships and of pathogenic ...

doaj  

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada   +13 more
wiley   +1 more source

Melittin Reprograms Tumor‐Associated Macrophages Through CD18‐Mediated Immunomodulation

open access: yesPhytotherapy Research, EarlyView.
Melittin selectively targets CD18 to deplete M2‐TAMs and remodel the TME to suppress tumor growth. ABSTRACT Tumor‐associated macrophages (TAMs), particularly the M2‐like subtype, contribute to an immunosuppressive tumor microenvironment and promote tumor progression.
Ik‐Hwan Han   +6 more
wiley   +1 more source

Purification and characterization of \u3cem\u3eHelicobacter pylori\u3c/em\u3e arginase, RocF: Unique features among the arginase superfamily

open access: yes, 2004
The urea cycle enzyme arginase (EC 3.5.3.1) hydrolyzes l-arginine to l-ornithine and urea. Mammalian arginases require manganese, have a highly alkaline pH optimum and are resistant to reducing agents.
Ochoa, Augusto C   +5 more
core   +1 more source

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