Results 81 to 90 of about 50,915 (302)

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

Arginase-1 expression and arginase activity in rat and mouse peritoneal macrophages.

, 2013
(A) (Top) RT-PCR analysis for the expression of arginase-1 mRNA. (Bottom) Amplicons densitometrically quantified; bars represent the relative amounts of amplified arginase-1 mRNA normalized against GAPDH.
Qing-Shi Ren (325122), Xing-Quan Zhu (107159), Zhi Li (72309), Fang-Li Lu (325127), Jiang-Mei Gao (325124), Xiao-Guang Chen (325128), Xiao-Jie Gao (325125), Wen-Liang Zhou (276285), Yong Wang (12837), Ji-Long Shen (278370), Geoff Hide (2160), Ting-Bao Yang (325126), Zhi-Jun Zhao (287192), Francisco J. Ayala (156974), Zhao-Rong Lun (104756), Fang-Fang Nie (325123)   +15 more
core   +1 more source

Macrophage Migration Inhibitory Factor (MIF) Is Essential for Type 2 Effector Cell Immunity to an Intestinal Helminth Parasite

Frontiers in Immunology, 2019
Immunity to intestinal helminths is known to require both innate and adaptive components of the immune system activated along the Type 2 IL-4R/STAT6-dependent pathway.
Kara J. Filbey, Fumi Varyani, Fumi Varyani, Yvonne Harcus, James P. Hewitson, Danielle J. Smyth, Henry J. McSorley, Alasdair Ivens, Susanne Nylén, Martin Rottenberg, Stephan Löser, Rick M. Maizels   +11 more
doaj   +1 more source

Self‐Adaptive Biomimetic Nanocomposite Hydrogel Orchestrates Dual‐Targeting and On‐Demand H2S Gasotransmission for Multifactorial Diabetic Wound Therapy

Advanced Science, EarlyView.
A self‐adaptive and biomimetic nanocomposite hydrogel is engineered to orchestrate dual‐targeting and on‐demand H2S gasotransmission for multifactorial diabetic wound therapy. By seamlessly integrating antibacterial, antioxidant, anti‐inflammatory, immunoregulatory, and pro‐angiogenic functions within a single platform, this hydrogel dynamically ...
Kefan Wu, Xiaoxue Yang, Yonghang Liu, Yi Xiao, Shiyu Meng, Ao Li, Yi Zhun Zhu, Hui Guo, Xiaolin Wang   +8 more
wiley   +1 more source

Arginase-expressing cells in biopsy are neutrophils.

, 2013
The phenotype of arginase-expressing cells in homogenates of skin biopsies was determined by flow cytometry by using a combination of antibodies against CD14, CD15 and arginase.
Mihretu Woldeyes (319704), Manuel Modolell (59010), Pascale Kropf (59011), Ingrid Müller (59004), Asrat Hailu (59005), Kassahun Bilcha (319706), Woinshet Mekonen (319705), Lionel Fry (319708), Fabienne Tacchini-Cottier (102063), Tamrat Abebe (59007), Nafisa-Katrin Seich al Basatena (201133), Thomas Cloke (299191), Markus Munder (59009), Karina Corware (319710)   +13 more
core   +1 more source

Spontaneous T-cell responses against Arginase-1 in the chronic myeloproliferative neoplasms relative to disease stage and type of driver mutation

OncoImmunology, 2018
Compelling evidence supports the existence of a profound immune dysregulation in patients with chronic myeloproliferative neoplasms (MPN). Increased Arginase-1 expression has been described in MPN patients and in solid cancers.
Mia Aaboe Jørgensen, Morten Orebo Holmström, Evelina Martinenaite, Caroline Hasselbalch Riley, Hans Carl Hasselbalch, Mads Hald Andersen   +5 more
doaj   +1 more source

Structure and Function of Arginases [PDF]

The Journal of Nutrition, 2004
The arginases catalyze the divalent cation dependent hydrolysis of L-arginine to produce L-ornithine and urea. Although traditionally considered in terms of its role as the final enzyme of the urea cycle, the enzyme is found in a variety of nonhepatic tissues.
openaire   +2 more sources

Epithelial SLC25A20 Deficiency Drives Immunosuppressive Neutrophil Remodeling via ARG1 Palmitoylation to Promote Colorectal Cancer

Advanced Science, EarlyView.
SLC25A20 deficiency in tumor cells compromises mitochondrial LCFA transport, which suppresses FAO and drives compensatory release of palmitic acid‐enriched lipids into the TME. These tumor‐derived palmitic acids are taken up by TANs, promoting ZDHHC18‐catalyzed ARG1 palmitoylation.
Yue Han, Tian‐Yuan Tan, Bin Zhang, Ye‐Bin Fu, Wen Chen, Min‐Hui Yang, Yi‐Qing Wang, Yan‐Qing Ding, Shuang Wang   +8 more
wiley   +1 more source

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

Advanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen, Zhenguo Cao, Zenan Wang, Liang Chen, Jiahao Zhang, Linjie Zeng, Boren Tan, Hengyuan Li, Jiashan Lai, Jiangchu Lei, Fanglu Chen, Peng Lin, Zhenxuan Shao, Zhan Wang   +13 more
wiley   +1 more source