Results 31 to 40 of about 113,590,771 (217)

Epithelial arginase-1 is a key mediator of age-associated delayed healing in vaginal injury

Frontiers in Endocrinology, 2022
Pelvic organ prolapse is a disorder that substantially affects the quality of life of millions of women worldwide. The greatest risk factors for prolapse are increased parity and older age, with the largest group requiring surgical intervention being ...
Holly N. Wilkinson, Benjamin Reubinoff, Benjamin Reubinoff, David Shveiky, David Shveiky, Matthew J. Hardman, Ofra Ben Menachem-Zidon   +6 more
doaj   +1 more source

Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency. [PDF]

Mol Genet Metab Rep, 2016
Arginase-1 (Arg1) converts arginine to urea and ornithine in the distal step of the urea cycle in liver. We previously generated a tamoxifen-inducible Arg1 deficient mouse model (Arg1-Cre) that disrupts Arg1 expression throughout the whole body and leads to lethality ≈ 2 weeks after gene disruption.
Ballantyne LL, Sin YY, Al-Dirbashi OY, Li X, Hurlbut DJ, Funk CD.   +5 more
europepmc   +4 more sources

Hepatic Ischemia-Reperfusion Impairs Blood-Brain Barrier Partly Due to Release of Arginase From Injured Liver

Frontiers in Pharmacology, 2021
Aim: Hepatic ischemia-reperfusion (HIR) induces remote organs injury, including the brain. The homeostasis of the brain is maintained by the blood-brain barrier (BBB); thus, we aimed to investigate whether HIR impaired BBB and attempted to elucidate its ...
Liang Zhu, Han Zhou, Feng Xu, Hanyu Yang, Ping Li, Yun Sheng, Peihua Liu, Weimin Kong, Xiaonan Liu, Lu Yang, Li Liu, Xiaodong Liu   +11 more
doaj   +1 more source

Phenotypic pleiotropy in arginase deficiency: A single center cohort

Annals of Indian Academy of Neurology, 2022
Background: Arginase deficiency is considered a masquerader of diplegic cerebral palsy. The rarity of hyperammonemic crisis and the slowly progressive course has made it a unique entity among the urea cycle defects. Objectives: The aim of our study is to
Narmadham K Bharathi, Maya Mary Thomas, Sangeetha Yoganathan, Mahalakshmi Chandran, Rekha Aaron, Sumita Danda   +5 more
doaj   +1 more source

Identification of ARG1 Mutations in Patients with Arginase 1 Deficiency

Clinical Medicine And Health Research Journal, 2022
Introduction: Argininemia is an autosomal recessive uncommon metabolic condition, caused by mutations in arginase enzyme. Variable clinical symptoms of argininemia might bring about a delayed diagnosis. In order to prove an argininemia condition, a genetic test result is needed. This study aims to describe two cases of argininemia homozygote mutations.
Ali Kowsari, Mahboobeh Rafigh, Mahsa Kazerani, Saba Fakharianzadeh, Abdolazim Sarli   +4 more
openaire   +1 more source

Lethal phenotype in conditional late-onset arginase 1 deficiency in the mouse. [PDF]

Mol Genet Metab, 2013
Human arginase deficiency is characterized by hyperargininemia and infrequent episodes of hyperammonemia, which lead to neurological impairment with spasticity, loss of ambulation, seizures, and severe mental and growth retardation; uncommonly, patients suffer early death from this disorder.
Kasten J, Hu C, Bhargava R, Park H, Tai D, Byrne JA, Marescau B, De Deyn PP, Schlichting L, Grody WW, Cederbaum SD, Lipshutz GS.   +11 more
europepmc   +5 more sources

Arginase activity - a marker of disease status in patients with visceral leishmaniasis in ethiopia. [PDF]

, 2013
The underlying mechanisms resulting in the profound immune suppression characteristic of human visceral leishmaniasis (VL) are not fully understood. Here, we tested the hypothesis that arginase, an enzyme associated with immunosuppression, is higher in ...
Corset, C, Cloke Tom, Closs Ellen, Cloke, T, Yifru Sisay, Abebe Tamrat, Corset, M, Modolell, M, Takele, Yegnasew, Corware, Karina, Cloke, Tom, Sisay Yifru, Hailu, Workagegnehu, Munder, M, Tacchini-Cottier, F, Ingrid Müller, Kropf, P, Müller, Ingrid, Markus Munder, Weldegebreal, T, Weldegebreal Teklu, Teklu Weldegebreal, Closs, E, Sisay, Y, Hailu, W, Mueller, I, Pascale Kropf, Camille Corset, Müller Ingrid, Sisay, Yifru, Takele Yegnasew, Closs, Ellen, Karina Corware, Weldegebreal, Teklu, Modolell, Manuel, Corware, K, Asrat Hailu, Corware Karina, Abebe, T, Corset Margaux, Munder, Markus, Manuel Modolell, Hailu Workagegnehu, Hailu, A, Margaux Corset, Modolell Manuel, Workagegnehu Hailu, Kropf Pascale, Abebe, Tamrat, Tacchini-Cottier, Fabienne, Fabienne Tacchini-Cottier, Yegnasew Takele, Kropf, Pascale, Corset Camille, Munder Markus, Tom Cloke, Corset, Margaux, Ellen Closs, Tacchini-Cottier Fabienne, Hailu Asrat, Corset, Camille, Hailu, Asrat, Takele, Y, Tamrat Abebe, Closs, E., Abebe, T., Corset, C., Takele, Y., Sisay, Y., Hailu, A., Müller, I., Weldegebreal, T., Corset, M., Corware, K., Cloke, T., Modolell, M., Munder, M., Kropf, P., Tacchini-Cottier, F., Hailu, W.   +79 more
core   +1 more source

Arginase from kiwifruit: properties and seasonal variation [PDF]

, 1997
The in vitro activity of arginase (EC 3.5.3.1) was investigated in youngest-mature leaves and roots (1-3 mm diameter) of kiwifruit vines (Actinidia deliciosa var. deliciosa) during an annual growth cycle, and enzyme from root material partially purified.
Petach, Helen H., C. A. Hale, C. J. Clark, H. H. Petach, Clark, Christopher J., Daniel, Roy M., R. M. Daniel, Hale, C.A.   +7 more
core   +1 more source

Local increase of arginase activity in lesions of patients with cutaneous leishmaniasis in Ethiopia. [PDF]

, 2012
BACKGROUND: Cutaneous leishmaniasis is a vector-borne disease that is in Ethiopia mainly caused by the parasite Leishmania aethiopica. This neglected tropical disease is common in rural areas and causes serious morbidity.
Cloke, T, Abebe Tamrat, Mekonen Woinshet, Modolell, M, Thomas Cloke, Woldeyes Mihretu, Seich Al Basatena, Nafisa-Katrin, Abebe, T., Corware, Karina, Bilcha, K, Seich al Basatena, N., Munder, M, Lionel Fry, Tacchini-Cottier, F, Ingrid Müller, Kropf, P, Müller, Ingrid, Markus Munder, Bilcha, K., Fry Lionel, Seich Al Basatena, N.K., Cloke Thomas, Hailu, A., Cloke, Thomas, Mueller, I, Mihretu Woldeyes, Pascale Kropf, Müller Ingrid, Mekonen, Woinshet, Karina Corware, Modolell, Manuel, al Basatena, N-KS, Müller, I., Woldeyes, M, Woinshet Mekonen, Corware, K, Asrat Hailu, Kassahun Bilcha, Corware Karina, Abebe, T, Woldeyes, Mihretu, Munder, Markus, Manuel Modolell, Mekonen, W., Hailu, A, Modolell Manuel, Fry, Lionel, Kropf Pascale, Abebe, Tamrat, Fry, L., Fry, L, Corware, K., Cloke, T., Modolell, M., Munder, M., Tacchini-Cottier, Fabienne, Fabienne Tacchini-Cottier, Kropf, P., Kropf, Pascale, Bilcha, Kassahun, Tacchini-Cottier, F., Woldeyes, M., Munder Markus, Nafisa-Katrin Seich Al Basatena, Mekonen, W, Tacchini-Cottier Fabienne, Hailu Asrat, Hailu, Asrat, Tamrat Abebe, Bilcha Kassahun, Seich al Basatena Nafisa-Katrin   +70 more
core   +1 more source

Cytotoxicity of tumor antigen specific human T cells is unimpaired by arginine depletion. [PDF]

, 2013
Tumor-growth is often associated with the expansion of myeloid derived suppressor cells that lead to local or systemic arginine depletion via the enzyme arginase.
Hundemer, Michael, Voss, R-H, Sergej Medenhoff, Voss Ralf-Holger, Goldschmidt, Hartmut, Knies, D, Anthony D Ho, Voss, Ralf-Holger, Knies Diana, Engelhardt, Melanie, Wabnitz, Guido, Knies, Diana, Michael Hundemer, Diana Knies, Yvonne Samstag, Munder, M, Feldmeyer, N, Samstag, Y, Theobald, Matthias, Ingrid Müller, Kropf, P, Müller, Ingrid, Markus Munder, Conradi Roland, Nadja Feldmeyer, Luckner-Minden, Claudia, Conradi, R, Roland Conradi, Mueller, I, Pascale Kropf, Matthias Theobald, Wabnitz, G, Conradi, Roland, Ho, AD, Müller Ingrid, Goldschmidt Hartmut, Hundemer Michael, Hundemer, M, Medenhoff, Sergej, Claudia Luckner-Minden, Luckner-Minden Claudia, Wabnitz Guido, Engelhardt, M, Samstag, Yvonne, Munder, Markus, Guido Wabnitz, Feldmeyer, Nadja, Theobald, M, Feldmeyer Nadja, Engelhardt Melanie, Medenhoff Sergej, Kropf Pascale, Hartmut Goldschmidt, Theobald Matthias, Ho, Anthony D, Medenhoff, S, Ralf-Holger Voss, Goldschmidt, H, Kropf, Pascale, Munder Markus, Ho Anthony D., Samstag Yvonne, Melanie Engelhardt, Luckner-Minden, C   +63 more
core   +2 more sources