Results 51 to 60 of about 113,590,771 (217)

Hyperargininemia in an inducible arginase‐1 deficient mouse model

The FASEB Journal, 2013
We generated an inducible arginase‐1 (Arg1) deficient mouse model by crossing “floxed” Arg1 mice with the Cre‐ER‐T2 model (Arg1‐Cre). These Arg1‐Cre mice die about 2 weeks after tamoxifen administration regardless of the starting age of inducing the knockout and show signs of hyperammonemia and significantly elevated arginine levels (n=4–5; four time ...
Angie Sin, Laurel L Ballantyne, Kamalika Mukherjee, Tim St. Amand, Crystal McCracken, Valeriy Levandovskiy, Andreas Schulze, Colin D Funk   +7 more
openaire   +1 more source

Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma

Respiratory Research, 2006
Background Using guinea pig tracheal preparations, we have recently shown that endogenous arginase activity attenuates inhibitory nonadrenergic noncholinergic (iNANC) nerve-mediated airway smooth muscle relaxation by reducing nitric oxide (NO) production
Zaagsma Johan, Bos I Sophie T, Leusink John, Maarsingh Harm, Meurs Herman   +4 more
doaj   +1 more source

Inactivation of Interleukin‐4 Receptor α Signaling in Myeloid Cells Protects Mice From Angiotensin II/High Salt–Induced Cardiovascular Dysfunction Through Suppression of Fibrotic Remodeling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Hypertension‐induced cardiovascular remodeling is characterized by chronic low‐grade inflammation. Interleukin‐4 receptor α (IL‐4Rα) signaling is importantly involved in cardiovascular remodeling, however, the target cell type(s) is unclear ...
Jianrui Song, Ryan A. Frieler, Thomas M. Vigil, Jun Ma, Frank Brombacher, Sascha N. Goonewardena, Daniel R. Goldstein, Richard M. Mortensen   +7 more
doaj   +1 more source

Downregulation of eNOS and preserved endothelial function in endothelial-specific arginase 1-deficient mice

Nitric Oxide, 2022
Arginase 1 (Arg1) is a ubiquitous enzyme belonging to the urea cycle that catalyzes the conversion of l-arginine into l-ornithine and urea. In endothelial cells (ECs), Arg1 was proposed to limit the availability of l-arginine for the endothelial nitric oxide synthase (eNOS) and thereby reduce nitric oxide (NO) production, thus promoting endothelial ...
Sophia K. Heuser, Anthea LoBue, Junjie Li, Zhengbing Zhuge, Francesca Leo, Tatsiana Suvorava, Annika Olsson, Rebekka Schneckmann, Drielle D. Guimaraes Braga, Tanu Srivrastava, Lidia Montero, Oliver J. Schmitz, Joachim P. Schmitt, Maria Grandoch, Eddie Weitzberg, Jon O. Lundberg, John Pernow, Malte Kelm, Mattias Carlström, Miriam M. Cortese-Krott   +19 more
openaire   +3 more sources

Increased Arginase Expression and Decreased Nitric Oxide in Pig Donor Lungs after Normothermic Ex Vivo Lung Perfusion

Biomolecules, 2020
An established pig lung transplantation model was used to study the effects of cold ischemia time, normothermic acellular ex vivo lung perfusion (EVLP) and reperfusion after lung transplantation on l-arginine/NO metabolism in lung tissue.
Farshad Tavasoli, Mingyao Liu, Tiago Machuca, Riccardo Bonato, David R. Grant, Marcelo Cypel, Shaf Keshavjee, Hartmut Grasemann   +7 more
doaj   +1 more source

Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency

, 2015
Arginase deficiency is caused by deficiency of arginase 1 (ARG1), a urea cycle enzyme that converts arginine to ornithine. Clinical features of arginase deficiency include elevated plasma arginine levels, spastic diplegia, intellectual disability ...
Lee, Brendan H, Burrage, Lindsay C, Elsea, Sarah H, Johnson, Dale E, Baumgartner, Matthias R; https://orcid.org/, Georgiou, George, Jiang, Ming-Ming, Stone, Everett, et al, Nagamani, Sandesh C S, Alters, Susan E, Frankel, Arthur E, Sun, Qin, Rowlinson, Scott W   +13 more
core   +1 more source

Macrophage–Fibroblast Crosstalk Governs Tumor Mechanics, as Revealed by Spatiotemporal Force Mapping in 3D Spheroids

Advanced Healthcare Materials, EarlyView.
This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar, Daan Vorselen, Jai Prakash   +2 more
wiley   +1 more source

Cytokine Signaling Protein 3 (SOCS3) deficiency in myeloid cells promotes retinal degeneration and angiogenesis through arginase-1 up-regulation in experimental autoimmune uveoretinitis [PDF]

, 2018
The suppressor of cytokine signalling protein 3 (SOCS3) critically controls immune cell activation, although its role in macrophage polarization and function remains controversial.
Xu, Heping, Mei Chen, Marry, Stephen, Jiawu Zhao, Chen, Mei, Stephen Marry, Imran H.A. Ali, Augustine, Josy; id_orcid, Zhao, Jiawu, Bhuckory, Mohajeet, Ali, Imran Ha, Adrien Kissenpfennig, Lynch, Aisling, Heping Xu, Josy Augustine, Mohajeet Bhuckory, Aisling Lynch, Kissenpfennig, Adrien   +17 more
core   +1 more source

Topically Delivered Treg‐Attracting Microparticle‐Hydrogel Composites Recruit Regulatory T Cells and Limit Cardiac Injury After Severe Ischemia

Advanced Healthcare Materials, EarlyView.
CCL22‐releasing PLGA microparticles (MP) suspended in topically applied hydrogels (HEART) establish a sustained chemokine gradient at the injured myocardium. HEART recruits CCR4+ regulatory T cells, reduces infarct size and graft fibrosis, and improves cardiac function.
Matthew A. Borrelli, Alexis T. Reese, Jordan J. P. Warunek, Betsy Ann Varghese, Canxing Lin, Jeffery J. Baust, Brenda McMahon, Steven R. Little, Hēth R. Turnquist   +8 more
wiley   +1 more source

Arginase-2 mediates diabetic renal injury [PDF]

, 2011
OBJECTIVE—To determine 1) whether renal arginase activity or expression is increased in diabetes and 2) whether arginase plays a role in development of diabetic nephropathy (DN). RESEARCH DESIGN AND METHODS—The impact of argi-nase activity and expression
Sidney M. Morris, Diane Kepka-lenhart, Ting Gao, Timothy K. Cooper, Alaa S. Awad   +4 more
core   +1 more source