Results 91 to 100 of about 5,976,322 (209)
Biotechnology and Bioengineering, EarlyView.ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu +3 more
wiley +1 more source
Inhibition of p38mapk reduces adipose tissue inflammation in aging mediated by arginase-II
, 2021 Background: Adipose tissue inflammation occurs not only in obesity but also in aging and is mechanistically linked with age-associated diseases. Studies show that ablation of the l-arginine-metabolizing enzyme arginase-II (Arg-II) reduces adipose ...
Huang, Ji +3 more
core
BMEMat, EarlyView.The regeneration process following dLhCG engraftment progressed through four distinct and interconnected stages. dLhCG maintained its regenerative efficacy after 6 months of cosmic exposure, supporting its potential application in space medicine.
Xu Hu +8 more
wiley +1 more source
A bioinspired catalytic nanoplatform for ferroptosis‐immunotherapy synergy in metastatic cancer
BMEMat, EarlyView.The bioinspired nanoplatform MnMSN@MnP‐PEG co‐delivers manganese peroxidase and manganese ions to synergistically induce immunogenic ferroptosis and activate the cGAS‐STING pathway, eliciting potent antitumor immunity against primary and metastatic tumors.
Panpan Xue +8 more
wiley +1 more source
Enteral arginase II provides ornithine for citrulline synthesis
, 2011 The synthesis of citrulline from arginine in the small intestine depends on the provision of ornithine. To test the hypothesis that arginase II plays a central role in the supply of ornithine for citrulline synthesis, the contribution of dietary ...
Inka Cajo Didelija +4 more
core +1 more source
Elevation of Arginase-II in Podocytes Contributes to Age-Associated Albuminuria in Male Mice. [PDF]
Int J Mol Sci, 2023 Ajalbert G +4 more
europepmc +1 more source
BMEMat, EarlyView.This review systematically summarizes the major molecular mechanisms governing TAM polarization and their coordinated interactions. It further highlights recent advances in nanoagonist‐based strategies that intervene in these pathways to reprogram TAMs, critically discussing their therapeutic potential, current limitations, and translational prospects.
Siqi Fang +7 more
wiley +1 more source
СТАТЬЯ ОТОЗВАНА: Аргиназа II - новая мишень для создания эндотелиопротекторов [PDF]
, 2018 RETRACTED ARTICLEThe article describes arginase’s role in pathogenesis of endothelial dysfunction and a number of cardio-vascular diseases. Arginase catalyzes the hydrolysis of L-arginine, the substrate for nitric oxide synthesis, to L-ornithine and urea.
M. V. Pokrovsky +13 more
core
Mitochondrial arginase II modulates nitric-oxide synthesis through nonfreely exchangeable L-arginine pools in human endothelial cells. [PDF]
, 2006 International audienceReduced synthesis of nitric oxide (NO) contributes to the endothelial dysfunction and may be related to limited availability of L-arginine, the common substrate of constitutive nitric-oxide synthase (NOS) and cytosolic arginase I ...
Topal, Gökce +6 more
core +1 more source
Vasomotor Regulation of Coronary Microcirculation by Oxidative Stress: Role of Arginase
Frontiers in Immunology, 2013 Overproduction of reactive oxygen species, i.e., oxidative stress, is associated with the activation of redox signaling pathways linking to inflammatory insults and cardiovascular diseases by impairing endothelial function and consequently blood flow ...
Lih eKuo +4 more
doaj +1 more source