Results 91 to 100 of about 5,115,447 (250)

Identification of an Arginase II Inhibitor via RapidFire Mass Spectrometry Combined with Hydrophilic Interaction Chromatography

SLAS discovery : advancing life sciences R & D, 2018
Peripheral arterial disease (PAD) is an occlusive disease that can lead to atherosclerosis. The involvement of arginase II (Arg II) in PAD progression has been proposed.
Wataru Asano, Yu Takahashi, Motoaki Kawano, Y. Hantani   +3 more
semanticscholar   +1 more source

Effects of Arginase I and II on local production of NO

The FASEB Journal, 2008
Dysfunction of endothelial nitric oxide synthase (eNOS) has been implicated in cardiovascular diseases such as hypertension and diabetes. Arginase I and II (Arg I, II) degrade the substrate for eNOS, L‐arginine and decrease nitric oxide (NO) production.
Shawn Elms, David Fulton
openaire   +1 more source

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

Plasmatic Concentrations of ADMA and Homocystein in Llama (Lama glama) and Regulation of Arginase Type II: An Animal Resistent to the Development of Pulmonary Hypertension Induced by Hypoxia

Frontiers in Physiology, 2018
There are animal species that have adapted to life at high altitude and hypobaric hypoxia conditions in the Andean highlands. One such species is the llama (Lama glama), which seem to have developed efficient protective mechanisms to avoid maladaptation ...
Vasthi López, Fernando A. Moraga, Anibal J. Llanos, German Ebensperger, María I. Taborda, Elena Uribe   +5 more
doaj   +1 more source

Genetic polymorphisms in arginase I and II and childhood asthma and atopy [PDF]

Journal of Allergy and Clinical Immunology, 2006
A recent microarray study implicated arginase I (ARG1) and arginase II (ARG2) in mouse allergic asthma models and human asthma.To examine the association between genetic variation in ARG1 and ARG2 and childhood asthma and atopy risk.We enrolled 433 case-parent triads, consisting of patients with asthma 4 to 17 years old and their biologic parents, from
Huiling, Li, Isabelle, Romieu, Juan-Jose, Sienra-Monge, Matiana, Ramirez-Aguilar, Blanca, Estela Del Rio-Navarro, Emily O, Kistner, Håkon K, Gjessing, Irma Del Carmen, Lara-Sanchez, Grace Y, Chiu, Stephanie J, London   +9 more
openaire   +2 more sources

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

High levels of tumor-associated neutrophils are associated with improved overall survival in patients with stage II colorectal cancer. [PDF]

PLoS ONE, 2017
Conflicting reports regarding whether high tumor-associated neutrophils (TAN) are associated with outcomes in colorectal cancer (CRC) exist. Previous investigators have counted TAN using non-neutrophil-specific immunohistochemistry (IHC) stains.
Ryan S Berry, Meng-Jun Xiong, Alissa Greenbaum, Parisa Mortaji, Robert A Nofchissey, Fred Schultz, Cathleen Martinez, Li Luo, Katherine T Morris, Joshua A Hanson   +9 more
doaj   +1 more source

Polycaprolactone/chitosan/manganese (II) oxide nanofiber: improving pH stability of arginase enzyme

Polymer Bulletin
This study explores the fabrication and characterization of advanced polycaprolactone (PCL)/chitosan (CS)/manganese (II) oxide (MnO) nanofiber for the immobilization of arginase.
Ceyhun Işık, M. Teke
semanticscholar   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source