Free energy analyses of cell-penetrating peptides using the weighted ensemble method [PDF]
Membranes 11, 974 (2021), 2021 Cell-penetrating peptides (CPPs) have been widely used for drug-delivery agents; however, it has not been fully understood how they translocate across cell membranes. The Weighted Ensemble (WE) method, one of powerful and flexible path sampling techniques, can be helpful to reveal translocation paths and free energy barriers along those paths.
arxiv
Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands [PDF]
, 2015 Short chain fatty acids (SCFAs) are produced in the gut by bacterial fermentation of poorly digested carbohydrates. A key mediator of their actions is the G protein-coupled Free Fatty Acid 2 (FFA2) receptor and this has been suggested as a therapeutic ...
Hansen, Anders Højgaard +6 more
core +1 more source
Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Communications Biology, 2018 Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy.
Chun-Ting Cheng +24 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran +3 more
wiley +1 more source
Dietary Arginine Regulates Severity of Experimental Colitis and Affects the Colonic Microbiome
Frontiers in Cellular and Infection Microbiology, 2019 There is great interest in safe and effective alternative therapies that could benefit patients with inflammatory bowel diseases (IBD). L-arginine (Arg) is a semi-essential amino acid with a variety of physiological effects.
Kshipra Singh +25 more
doaj +1 more source
Arginine Alters miRNA Expression Involved in Development and Proliferation of Rat Mammary Tissue
Animals, 2021 This study was designed to determine the effects of dietary arginine on development and proliferation in rat mammary tissue through changes in miRNA profiles. Twelve pregnant Wistar rats were allocated randomly to two groups.
Gang Zhou +8 more
doaj +1 more source
Role of water in the enzymatic catalysis: study of ATP + AMP -> 2ADP conversion by adenylate kinase [PDF]
J. Phys. Chem. A (2010), 2010 The catalytic conversion ATP + AMP -> 2ADP by the enzyme adenylate kinase (ADK) involves the binding of one ATP molecule to the LID domain and one AMP molecule to the NMP domain. The latter is followed by a phosphate transfer, and then the release of two ADP molecules. We have computed a novel two dimensional configurational free energy surface (2DCFES)
arxiv +1 more source
Arginine-deprivation–induced oxidative damage sterilizes Mycobacterium tuberculosis
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Tuberculosis results in over 1.7 million deaths annually; this problem is worsened by the emergence of drug-resistant strains. New drugs and a better understanding of the mechanisms of existing interventions are needed to prevent the ...
S. Tiwari +13 more
semanticscholar +1 more source
Poultry Science, 2020 This study investigated the effects of dietary Arginine (Arg) on performance, intestinal antioxidative capacity, immunity, and gut microbiota in Chinese yellow-feathered chickens. One thousand two hundred 1-day-old female Qingyuan partridge chickens were
D. Ruan +10 more
doaj
Identification of N-terminal protein acetylation and arginine methylation of the voltage-gated sodium channel in end-stage heart failure human heart [PDF]
, 2014 The α subunit of the cardiac voltage-gated sodium channel, Naᵥ1.5, provides the rapid sodium inward current that initiates cardiomyocyte action potentials.
Batlle, Montserrat +13 more
core +1 more source