Results 101 to 110 of about 805,592 (386)

Identification of N-terminal protein acetylation and arginine methylation of the voltage-gated sodium channel in end-stage heart failure human heart [PDF]

, 2014
The α subunit of the cardiac voltage-gated sodium channel, Naᵥ1.5, provides the rapid sodium inward current that initiates cardiomyocyte action potentials.
Batlle, Montserrat, Beltran-Alvarez, Pedro, Brugada, Ramon, Chiva, Cristina, Chiva, Critina, Pagans, Sara, Perez-Serra, Alexandra, Perez-Villa, Felix, Pérez-Serra, Alexandra, Pérez-Villa, Félix, Sabido, Eduard, Sabidó, Eduard, Schulte, Uwe, Tarradas, Anna   +13 more
core   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Dietary Arginine Regulates Severity of Experimental Colitis and Affects the Colonic Microbiome

Frontiers in Cellular and Infection Microbiology, 2019
There is great interest in safe and effective alternative therapies that could benefit patients with inflammatory bowel diseases (IBD). L-arginine (Arg) is a semi-essential amino acid with a variety of physiological effects.
Kshipra Singh, Kshipra Singh, Alain P. Gobert, Alain P. Gobert, Lori A. Coburn, Lori A. Coburn, Lori A. Coburn, Daniel P. Barry, Margaret Allaman, Mohammad Asim, Paula B. Luis, Paula B. Luis, Claus Schneider, Claus Schneider, Claus Schneider, Ginger L. Milne, Helen H. Boone, Meghan H. Shilts, M. Kay Washington, Suman R. Das, Suman R. Das, M. Blanca Piazuelo, Keith T. Wilson, Keith T. Wilson, Keith T. Wilson, Keith T. Wilson   +25 more
doaj   +1 more source

Arginine Alters miRNA Expression Involved in Development and Proliferation of Rat Mammary Tissue

Animals, 2021
This study was designed to determine the effects of dietary arginine on development and proliferation in rat mammary tissue through changes in miRNA profiles. Twelve pregnant Wistar rats were allocated randomly to two groups.
Gang Zhou, Qiaoyun Xu, Feifan Wu, Mengzhi Wang, Lianmin Chen, Liangyu Hu, Jingwen Zhao, Juan J. Loor, Jun Zhang   +8 more
doaj   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction

Communications Biology, 2018
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy.
Chun-Ting Cheng, Y. Qi, Yi Chang Wang, Kevin K. Chi, Yiyin Chung, C. Ouyang, Yun-Ru Chen, M. Oh, Xiangpeng Sheng, Yulong Tang, Yun-Ru Liu, H. H. Lin, Ching-Ying Kuo, Dustin E. Schones, Christina M. Vidal, Jenny C.-Y. Chu, Hung-Jung Wang, Yu Han Chen, K. Miller, P. Chu, Y. Yen, Lei Jiang, H. Kung, H. Kung, D. Ann   +24 more
semanticscholar   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Dietary L-arginine supplementation enhances growth performance, intestinal antioxidative capacity, immunity and modulates gut microbiota in yellow-feathered chickens

Poultry Science, 2020
This study investigated the effects of dietary Arginine (Arg) on performance, intestinal antioxidative capacity, immunity, and gut microbiota in Chinese yellow-feathered chickens. One thousand two hundred 1-day-old female Qingyuan partridge chickens were
D. Ruan, A.M. Fouad, Q.L. Fan, X.H. Huo, Z.X. Kuang, H. Wang, C.Y. Guo, Y.F. Deng, C. Zhang, J.H. Zhang, S.Q. Jiang   +10 more
doaj  

Physiological implications of arginine metabolism in plants

Frontiers in Plant Science, 2015
Nitrogen is a limiting resource for plant growth in most terrestrial habitats since large amounts of nitrogen are needed to synthesize nucleic acids and proteins.
Gudrun Winter, C. Todd, M. Trovato, G. Forlani, D. Funck   +4 more
semanticscholar   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source