Results 131 to 140 of about 844,163 (322)

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

High-salinity growth conditions promote tat-independent secretion of tat substrates in Bacillus subtilis [PDF]

, 2012
The Gram-positive bacterium Bacillus subtilis contains two Tat translocases, which can facilitate transport of folded proteins across the plasma membrane. Previous research has shown that Tat-dependent protein secretion in B.
Alami, Antelmann, Antelmann, Barnett, Barnett, Berks, Bogsch, Bolhuis, Bongers, Bron, Bursy, Carmine G. Monteferrante, Chaddock, Cline, Colin Robinson, Cristobal, DeLisa, Driessen, Eijlander, Gasson, Harwood, Hoper, James P. Barnett, Jan Maarten van Dijl, Jongbloed, Jongbloed, Jongbloed, Jongbloed, Kolkman, Kouwen, Kouwen, Kunst, Lewis, Maillard, Meile, Meissner, Mendel, Muller, Natale, Nicolas, Palmer, Palmer, Panahandeh, Pommier, René van der Ploeg, Ridder, Robinson, Robinson, Sambrook, Sargent, Sjouke Piersma, Stanley, Thijs R. H. M. Kouwen, Tjalsma, Tjalsma, Tullman-Ercek, van der Ploeg, van Dijl, van Roosmalen, Yuan   +59 more
core   +1 more source

Bioinspired Polypeptide Dendrimer‐Modified Thin‐Film Composite Membranes for Selective Lithium‐Magnesium Separation with DFT Insights

Advanced Functional Materials, EarlyView.
We fabricated a biomimetic dendrimer‐modified thin‐film nanocomposite membrane with a coordination‐assisted ion‐selective interface. pH‐responsive polypeptide sites preferentially bind Mg2+ and promote Li+ permeation, as predicted by density functional theory calculations of metal‐ligand interactions.
Mehrasa Yassari, Seyedeh Fatemeh Seyedpour, Bamlak Setegne, Amir Aghaei, Behzad Ahvazi, Mostafa Dadashi Firouzjaei, Mark Elliott, Mohtada Sadrzadeh   +7 more
wiley   +1 more source

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. [PDF]

, 2016
Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood.
Braas, Daniel, Christofk, Heather R, Graeber, Thomas G, Krall, Abigail S, Xu, Shili   +4 more
core   +1 more source

Drug‐Free Thrombolysis Mediated by Physically Activated Micro/Nanoparticles

Advanced Functional Materials, EarlyView.
Overview of particle‐mediated thrombolytic effects (thermal, mechanical, and chemical) and their activating physical stimuli (light, ultrasound, and magnetic field) in drug‐free thrombolysis. ABSTRACT Thrombus‐associated disorders rank among the world's leading causes of death, with ischemic heart disease and stroke as the main contributors.
Pierre Sarfati, Yoann Lalatonne, Cédric Chauvierre   +2 more
wiley   +1 more source

Fabrication and properties of L-arginine-doped PCL electrospun composite scaffolds

, 2017
The article describes fabrication and properties of composite fibrous scaffolds obtained by electrospinning of the solution of poly({\epsilon}-caprolactone) and arginine in common solvent.
Anissimov, Y. G., Bolbasov, E. N., Filimonov, V. D., Golovkin, A. S., Goreninskii, S. I., Mishanin, A. I., Stankevich, K. S., Sudarev, E. A., Tverdokhlebov, S. I., Viknianshchuk, A. N.   +9 more
core  

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Designing a precision-medicine platform trial to improve the nutritional care and intestinal health of very preterm babies: the COLLABORATE study

Efficacy and Mechanism Evaluation
Background Nutrition is essential for preterm brain development. Optimal nutrition is dependent upon gastrointestinal health. Primary objective To form a multiprofessional collaboration to design the world’s first neonatal precision-medicine platform ...
Neena Modi, Mohammad Chehrazi, James Boardman, Alan Boyd, Peter Bradley, Cecilia Cirelli, Stefano Giuliani, Lauren Ingledow, Caroline Lee-Davey, Paola Quattroni, Douglas Morrison, Colin Morgan, Ju-Lee Oei, Susan Ozanne, Kylie Pussell, Sabita Uthaya, Hilary Wong, Victoria Cornelius   +17 more
doaj   +1 more source

Self‐Assembling Peptide Hydrogels Support Stromal Vascular Fraction Viability to Promote In Vivo Nerve Regeneration

Advanced Healthcare Materials, EarlyView.
Stromal vascular fraction (SVF) may enhance nerve repair, especially when delivered in a self‐assembling peptide hydrogel (SAPH). In vitro, softer SAPH increased neuronal explant outgrowth and supported greater SVF viability and proliferation. In a rat sciatic defect, SVF in an optimized SAPH produced motor and sensory recovery equivalent to autograft ...
Liam A. McMorrow, Steffan Llewellyn, Jared McSweeney, Alessandro Faroni, Aline F. Miller, Alberto Saiani, Adam J. Reid   +6 more
wiley   +1 more source

Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes

Scientific Reports, 2018
Tumors deficient in the urea cycle enzymes argininosuccinate synthase-1 (ASS1) and ornithine transcarbamylase (OTC) are unable to synthesize arginine and can be targeted using arginine-deprivation therapy.
Constantinos Alexandrou, Saif Sattar Al-Aqbi, Jennifer A. Higgins, William Boyle, Ankur Karmokar, Catherine K. Andreadi, Jin-li Luo, D. Moore, M. Viskaduraki, Matthew J. Blades, G. Murray, L. Howells, Anne L. Thomas, K. Brown, P. Cheng, A. Rufini   +15 more
semanticscholar   +1 more source