Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel [PDF]
, 2014 Arginine methylation is a novel post-translational modification within the voltage-gated ion channel superfamily, including the cardiac sodium channel, Naᵥ1.5.
Beltran-Alvarez, Pedro +5 more
core +1 more source
Autophagy maintains tumor growth through circulating arginine
Nature, 2018 Autophagy captures intracellular components and delivers them to lysosomes, where they are degraded and recycled to sustain metabolism and to enable survival during starvation1–5.
Laura Poillet-Perez +16 more
semanticscholar +1 more source
Molecular Electroporation and the Transduction of Oligoarginines [PDF]
Phys. Biol. 7 (2010) 016001 (14pp), 2008 Certain short polycations, such as TAT and polyarginine, rapidly pass through the plasma membranes of mammalian cells by an unknown mechanism called transduction as well as by endocytosis and macropinocytosis. These cell-penetrating peptides (CPPs) promise to be medically useful when fused to biologically active peptides.
arxiv +1 more source
Proteomics profiling of arginine methylation defines PRMT5 substrate specificity
Science Signaling, 2019 Proteomics identifies target sites and substrates of the arginine methyltransferase PRMT5. Profiling PRMT5 The enzyme PRMT5 methylates arginine residues in target proteins to modify their function.
D. Musiani +12 more
semanticscholar +1 more source
Tailored second line therapy in asthmatic children with the arginine-16 genotype [PDF]
, 2012 The arginine-16 beta-2 receptor genotype confers increased susceptibility to exacerbations in asthmatic children taking regular long acting beta-2 agonists.
Aziz +27 more
core +1 more source
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, EarlyView.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
Can Arginine Help to Improve Milk Supply in Humans? It Does in Cows
Proceedings, 2023 Arginine can be metabolized into nitric oxide, polyamine, creatine, or agmatine, and each of those metabolites has several biological functions [...]
Luoyang Ding +7 more
doaj +1 more source
Arginine-Phosphate Salt Bridges Between Histones and DNA: Intermolecular Actuators that Control Nucleosome Architecture [PDF]
, 2014 Structural bioinformatics and van der Waals density functional theory are combined to investigate the mechanochemical impact of a major class of histone-DNA interactions, namely the formation of salt bridges between arginine residues in histones and phosphate groups on the DNA backbone.
arxiv +1 more source
Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome [PDF]
, 2007 Objective: Previous studies have shown the importance of somatic mutations and arginine residues in the complementarity-determining regions (CDRs) of pathogenic anti-double-stranded DNA (anti-dsDNA) antibodies in human and murine lupus, and in studies of
Giles, I. +7 more
core +1 more source
Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages
Frontiers in Immunology, 2014 Macrophages play a major role in the immune system, both as antimicrobial effector cells and as immunoregulatory cells, which induce, suppress or modulate adaptive immune responses.
Meera Rath +4 more
semanticscholar +1 more source