Results 61 to 70 of about 679,914 (276)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Multiomics integration for the function of bacterial outer membrane vesicles in the larval settlement of marine sponges

Frontiers in Microbiology
Bacterial outer membrane vesicles (OMVs) contain a variety of chemical compounds and play significant roles in maintaining symbiotic relationships in a changing ocean, but little is known about their function, particularly in sponge larval development ...
Beibei Zhang, Chenzheng Jia, Mingyu Li, Kai Wang, Jun Chen, Jing Zhao, Jing Zhao   +6 more
doaj   +1 more source

Crosstalk between arginine, glutamine, and the branched chain amino acid metabolism in the tumor microenvironment

Frontiers in Oncology, 2023
Arginine, glutamine, and the branched chain amino acids (BCAAs) are a focus of increased interest in the field of oncology due to their importance in the metabolic reprogramming of cancer cells.
Tanner J. Wetzel, Sheila C. Erfan, Lucas D. Figueroa, Leighton M. Wheeler, Elitsa A. Ananieva   +4 more
doaj   +1 more source

Is NO the Answer? The Nitric Oxide Pathway Can Support Bone Morphogenetic Protein 2 Mediated Signaling [PDF]

, 2019
The growth factor bone morphogenetic protein 2 (BMP2) plays an important role in bone development and repair. Despite the positive effects of BMP2 in fracture healing, its use is associated with negative side effects and poor cost effectiveness, partly ...
Bormann, Nicole, Differ, Christopher, Klatte-Schulz, Franka, Knaus, Petra, Minkwitz, Susann, Wildemann, Britt   +5 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Outdoor particulate matter exposure affects metabolome in chronic obstructive pulmonary disease: Preliminary study

Frontiers in Public Health, 2023
IntroductionThe metabolomic changes caused by airborne fine particulate matter (PM2.5) exposure in patients with chronic obstructive pulmonary disease (COPD) remain unclear.
Tao Yu, Tao Yu, Tao Yu, Tao Yu, Tao Yu, Hanna Wu, Hanna Wu, Hanna Wu, Hanna Wu, Hanna Wu, Qingxia Huang, Fen Dong, Fen Dong, Fen Dong, Fen Dong, Xuexin Li, Xuexin Li, Xuexin Li, Xuexin Li, Xuexin Li, Yushi Zhang, Yushi Zhang, Yushi Zhang, Yushi Zhang, Yushi Zhang, Ruirui Duan, Ruirui Duan, Ruirui Duan, Ruirui Duan, Hongtao Niu, Hongtao Niu, Hongtao Niu, Hongtao Niu, Ting Yang, Ting Yang, Ting Yang, Ting Yang   +36 more
doaj   +1 more source

Differential sensitivity of basal and acetylcholine-induced activity of nitric oxide to blockade by asymmetric dimethylarginine (ADMA) in the rat aorta [PDF]

, 2010
<b>Background and purpose</b>: Previous work has shown that NG-monomethyl-l-arginine (l-NMMA) paradoxically inhibits basal, but not ACh-stimulated activity of nitric oxide in rat aorta.
Archer, Boger, Cocks, De Gennaro Colonna, Dora, Dudzinski, Feng, Fleming, Frew, Fulton, Gallis, Hobbs, Jackson, Jin, Leiper, Liu, Martin, Martin, Miller, Moore, Olken, Overend, Palmer, Rapoport, Rees, Rees, Siroen, Vallance, Vallance, Vladimirova-Kitova   +29 more
core   +3 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Pegylated arginine deiminase synergistically increases the cytotoxicity of gemcitabine in human pancreatic cancer. [PDF]

, 2014
BackgroundPancreatic ductal adenocarcinoma has proven to be one of the most chemo-resistant among all solid organ malignancies. Several mechanisms of resistance have been described, though few reports of strategies to overcome this chemo-resistance have ...
Bold, Richard J, Daylami, Rouzbeh, Muilenburg, Diego J, Virudachalam, Subbulakshmi   +3 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source