Results 41 to 50 of about 388,707 (260)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Effect of N-Carbamylglutamate Supplementation in Late Pregnancy on Nutrient-Restricted Twin-Bearing Ewes on the Pre-Lambing Maternal Metabolome, Colostrum Quality and Lamb Birth Weight

Animals
Arginine supplementation improves fetal growth and colostrum composition in nutrient-restricted ewes, but its high cost and ruminal degradation limit its practical use. N-carbamylglutamate (NCG), which stimulates endogenous arginine synthesis, and is not
Francisco Sales, Susan McCoard, Pablo Alarcón, Camila Sandoval, Claudia Silva, Carolina Rojas, Víctor H. Parraguez   +6 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Factors related to the improvement of the right ventricular function in patients with pulmonary embolism at short-term follow-up

Медицина неотложных состояний, 2022
Background. The purpose was to study the possible influence of Tivorel on the improvement of the right ventricular (RV) function in patients with acute pulmonary embolism (PE). Materials and methods.
V.Y. Tseluyko, L.M. Yakovleva, S.M. Sukhova, O.V. Radchenko   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Evolution of histone 2A for chromatin compaction in eukaryotes

eLife, 2014
During eukaryotic evolution, genome size has increased disproportionately to nuclear volume, necessitating greater degrees of chromatin compaction in higher eukaryotes, which have evolved several mechanisms for genome compaction.
Benjamin R Macadangdang, Amit Oberai, Tanya Spektor, Oscar A Campos, Fang Sheng, Michael F Carey, Maria Vogelauer, Siavash K Kurdistani   +7 more
doaj   +1 more source

Effects of tofacitinib therapy on arginine and methionine metabolites in association with vascular pathophysiology in rheumatoid arthritis: A metabolomic approach

Frontiers in Medicine, 2022
IntroductionRheumatoid arthritis (RA) has been associated with changes in lipid, arginine and NO metabolism with increased cardiovascular (CV) risk.
Boglárka Soós, Attila Hamar, Anita Pusztai, Monika Czókolyová, Edit Végh, Szilvia Szamosi, Zsófia Pethő, Katalin Gulyás, György Kerekes, Sándor Szántó, Sándor Szántó, Gabriella Szűcs, Uwe Christians, Jelena Klawitter, Tamás Seres, Zoltán Szekanecz   +15 more
doaj   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Arginine as the sole nitrogen source for Ostreococcus tauri growth: Insights on nitric oxide synthase enzyme

Frontiers in Marine Science, 2022
IntroductionPhotosynthetic organisms respond to nitrogen (N) deprivation with the slowdown of photosynthesis and electron transport resulting in the balance the carbon (C)/N ratio.
Noelia Foresi, Gonzalo Caló, Fiorella Del Castello, Andres Nejamkin, Graciela Salerno, Lorenzo Lamattina, Giselle Martínez-Noël, Natalia Correa-Aragunde   +7 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source