Results 41 to 50 of about 458,229 (307)

Shotgun Metagenomic Sequencing Revealed the Prebiotic Potential of a Fruit Juice Drink with Fermentable Fibres in Healthy Humans

Foods, 2023
Fibre-based dietary interventions are at the forefront of gut microbiome modulation research, with a wealth of 16S rRNA information to demonstrate the prebiotic effects of isolated fibres.
Adri Bester, Marcus O’Brien, Paul D. Cotter, Sarita Dam, Claudia Civai   +4 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Alterations in the cecal microbiome of New Zealand White rabbits due to the long-acting anticoagulant rodenticide brodifacoum

Toxicology Communications
Introduction Long-acting anti-coagulant rodenticides (LAARs) are well characterized with respect to inhibition of vitamin K1 synthesis and effects on blood coagulation.
Ankur Naqib, Intakhar Ahmad, Zachary McDonald, Sergey Kalinin, Jackie Rocha, Ankit Tandon, Ramanjaneyulu Rayala, Leonid Feferman, George E. Chlipala, Hui Chen, Matthew Lindeblad, Israel Rubinstein, Stefan J. Green, Richard B. van Breemen, Douglas L. Feinstein   +14 more
doaj   +1 more source

Zein Nanoparticles Containing Arginine-Phenylalanine-Based Surfactants: Stability, Antimicrobial and Hemolytic Activity

Nanomaterials, 2023
Although cationic surfactants have a remarkable antimicrobial activity, they present an intrinsic toxicity that discourages their usage. In this work novel zein nanoparticles loaded with arginine-phenylalanine-based surfactants are presented.
Lourdes Perez, Zakaria Hafidi, Aurora Pinazo, Maria Teresa García, Manuel Martín-Pastor, Francisco Fábio Oliveira de Sousa   +5 more
doaj   +1 more source

Arginine Requirement and the Arginine Content of Casein

Poultry Science, 1964
Abstract Much has been written concerning the high arginine requirement of chicks fed diets based on casein as the source of protein. The peculiar amino acid balance of casein, as suggested by studies from this laboratory (Fisher, Shapiro and Griminger, 1960), may in part explain this phenomenon. We now wish to draw attention to a recently published
H. Fisher, P. Griminger
openaire   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The effects of acute arginine supplementation on 10 mile cycling time trial performance in young adult males [PDF]

, 2012
L-arginine is one of the most metabolically versatile amino acids in the human body, most notably serving as the pre-cursor for the biosynthesis of nitric oxide (NO).
Gill, Sam
core  

Dietary Supplementation with L-Citrulline Between Days 1 and 60 of Gestation Enhances Embryonic Survival in Lactating Beef Cows

Animals
Low fertility limits reproductive efficiency in cattle. This study was conducted with multiparous Brangus cows receiving dietary supplementation with or without L-citrulline [Cit; an immediate precursor of L-arginine (Arg)].
Kyler R. Gilbreath, Michael Carey Satterfield, Lan Zhou, Fuller W. Bazer, Guoyao Wu   +4 more
doaj   +1 more source

The Poly-Arginine Peptide R18D Interferes with the Internalisation of α-Synuclein Pre-Formed Fibrils in STC-1 Enteroendocrine Cells

Biomedicines, 2023
In Parkinson’s disease (PD), gut inflammation is hypothesised to contribute to α-synuclein aggregation, but gastrointestinal α-synuclein expression is poorly characterised.
Anastazja M. Gorecki, Holly Spencer, Bruno P. Meloni, Ryan S. Anderton   +3 more
doaj   +1 more source