Results 51 to 60 of about 458,229 (307)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Refolding Technology for scFv Using a New Detergent, N-Lauroyl-L-glutamate and Arginine

Antibodies, 2012
Monoclonal antibodies to the soluble antigens or cell surface markers hold great promise as effective human therapeutics. One of the major disadvantages is its large size, which prevents efficient penetration into the target tissues.
Tsutomu Arakawa, Yoshiko Kita, Daisuke Ejima   +2 more
doaj   +1 more source

PLLA Composites Combined with Delivery System of Bioactive Agents for Anti-Inflammation and Re-Endothelialization

Pharmaceutics, 2022
The development of a biodegradable vascular scaffold (BVS) for the treatment of cardiovascular diseases (CVDs) still requires some improvement. Among them, re-endothelialization and anti-inflammation are clinically important to restore vascular function.
Seung-Woon Baek, Da-Seul Kim, Duck Hyun Song, Semi Lee, Jun-Kyu Lee, So-Yeon Park, Jun Hyuk Kim, Tae-Hyung Kim, Chun Gwon Park, Dong Keun Han   +9 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Consequences of arginine and methionine supplementation on growth performance, intestinal health, and immune response in broiler chickens under concurrent heat stress and coccidia challenge

Poultry Science
We investigated the effects of arginine and methionine supplementation in reduced protein diets on performance of broilers under concurrent heat stress (HS) and coccidia challenge.
Guanchen Liu, Doyun Goo, Jihwan Lee, Adeleye M. Ajao, Revathi Shanmugasundaram, Elizabeth Ball, Yves Mercier, Todd J. Applegate, Ramesh Selvaraj, Ilias Kyriazakis, Oluyinka A. Olukosi, Woo K. Kim   +11 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Inhibition of Tumor Microenvironment-Driven JAK-STAT Signaling Enhances Response to Arginine Deprivation Therapy in Triple-Negative Breast Cancer

Cells
Argininosuccinate synthetase 1 (ASS1) expression and arginine availability are key metabolic determinants that influence tumor fitness and regulate immune interactions within the tumor microenvironment (TME).
Hila Tishler, Shahar Ziman, Kuoyuan Cheng, Kun Wang, Neel Sanghvi, Lital Adler, Gil Stelzer, Hillary Maniriho, Bareket Dassa, Elizabeta Bab-Dinitz, Michal Levi, Sivan Galai, Omer Goldman, Yarden Ariav, Naama Darzi, Saar Ezagouri, Nitsan Nimni, Nataly Rosenfeld, Ron Rotkopf, Alexander Brandis, Tevie Mehlman, Roni Oren, Mirie Zerbib, Yuri Kuznetsov, Sara Donzelli, Giovanni Blandino, Rony Seger, Eytan Ruppin, Ayelet Erez   +28 more
doaj   +1 more source

Nutrition et santé : lipides et protéines d’origine végétale - De nouvelles données pour juger de la qualité des protéines végétales chez l’homme - Implications et perspectives

Oléagineux, Corps gras, Lipides, 2003
La qualité des protéines pour l’alimentation de l’homme est un sujet très ancien mais les différentes méthodes proposées jusqu’ici pour évaluer la qualité protéique ont été largement critiquées, pour des problèmes conceptuels et méthodologiques.
Mariotti François, Tomé Daniel
doaj   +1 more source

Arginine Alters miRNA Expression Involved in Development and Proliferation of Rat Mammary Tissue

Animals, 2021
This study was designed to determine the effects of dietary arginine on development and proliferation in rat mammary tissue through changes in miRNA profiles. Twelve pregnant Wistar rats were allocated randomly to two groups.
Gang Zhou, Qiaoyun Xu, Feifan Wu, Mengzhi Wang, Lianmin Chen, Liangyu Hu, Jingwen Zhao, Juan J. Loor, Jun Zhang   +8 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source