Results 51 to 60 of about 490,412 (303)

Dietary Supplementation with L-Citrulline Between Days 1 and 60 of Gestation Enhances Embryonic Survival in Lactating Beef Cows

Animals
Low fertility limits reproductive efficiency in cattle. This study was conducted with multiparous Brangus cows receiving dietary supplementation with or without L-citrulline [Cit; an immediate precursor of L-arginine (Arg)].
Kyler R. Gilbreath, Michael Carey Satterfield, Lan Zhou, Fuller W. Bazer, Guoyao Wu   +4 more
doaj   +1 more source

Refolding Technology for scFv Using a New Detergent, N-Lauroyl-L-glutamate and Arginine

Antibodies, 2012
Monoclonal antibodies to the soluble antigens or cell surface markers hold great promise as effective human therapeutics. One of the major disadvantages is its large size, which prevents efficient penetration into the target tissues.
Tsutomu Arakawa, Yoshiko Kita, Daisuke Ejima   +2 more
doaj   +1 more source

PLLA Composites Combined with Delivery System of Bioactive Agents for Anti-Inflammation and Re-Endothelialization

Pharmaceutics, 2022
The development of a biodegradable vascular scaffold (BVS) for the treatment of cardiovascular diseases (CVDs) still requires some improvement. Among them, re-endothelialization and anti-inflammation are clinically important to restore vascular function.
Seung-Woon Baek, Da-Seul Kim, Duck Hyun Song, Semi Lee, Jun-Kyu Lee, So-Yeon Park, Jun Hyuk Kim, Tae-Hyung Kim, Chun Gwon Park, Dong Keun Han   +9 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Consequences of arginine and methionine supplementation on growth performance, intestinal health, and immune response in broiler chickens under concurrent heat stress and coccidia challenge

Poultry Science
We investigated the effects of arginine and methionine supplementation in reduced protein diets on performance of broilers under concurrent heat stress (HS) and coccidia challenge.
Guanchen Liu, Doyun Goo, Jihwan Lee, Adeleye M. Ajao, Revathi Shanmugasundaram, Elizabeth Ball, Yves Mercier, Todd J. Applegate, Ramesh Selvaraj, Ilias Kyriazakis, Oluyinka A. Olukosi, Woo K. Kim   +11 more
doaj   +1 more source

Arginine Alters miRNA Expression Involved in Development and Proliferation of Rat Mammary Tissue

Animals, 2021
This study was designed to determine the effects of dietary arginine on development and proliferation in rat mammary tissue through changes in miRNA profiles. Twelve pregnant Wistar rats were allocated randomly to two groups.
Gang Zhou, Qiaoyun Xu, Feifan Wu, Mengzhi Wang, Lianmin Chen, Liangyu Hu, Jingwen Zhao, Juan J. Loor, Jun Zhang   +8 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Inhibition of Tumor Microenvironment-Driven JAK-STAT Signaling Enhances Response to Arginine Deprivation Therapy in Triple-Negative Breast Cancer

Cells
Argininosuccinate synthetase 1 (ASS1) expression and arginine availability are key metabolic determinants that influence tumor fitness and regulate immune interactions within the tumor microenvironment (TME).
Hila Tishler, Shahar Ziman, Kuoyuan Cheng, Kun Wang, Neel Sanghvi, Lital Adler, Gil Stelzer, Hillary Maniriho, Bareket Dassa, Elizabeta Bab-Dinitz, Michal Levi, Sivan Galai, Omer Goldman, Yarden Ariav, Naama Darzi, Saar Ezagouri, Nitsan Nimni, Nataly Rosenfeld, Ron Rotkopf, Alexander Brandis, Tevie Mehlman, Roni Oren, Mirie Zerbib, Yuri Kuznetsov, Sara Donzelli, Giovanni Blandino, Rony Seger, Eytan Ruppin, Ayelet Erez   +28 more
doaj   +1 more source

Nutrition et santé : lipides et protéines d’origine végétale - De nouvelles données pour juger de la qualité des protéines végétales chez l’homme - Implications et perspectives

Oléagineux, Corps gras, Lipides, 2003
La qualité des protéines pour l’alimentation de l’homme est un sujet très ancien mais les différentes méthodes proposées jusqu’ici pour évaluer la qualité protéique ont été largement critiquées, pour des problèmes conceptuels et méthodologiques.
Mariotti François, Tomé Daniel
doaj   +1 more source