Results 61 to 70 of about 490,412 (303)

Interaction between NO and oxytocin: Influence on LHRH release

Brazilian Journal of Medical and Biological Research, 1997
Nitric oxide synthase (NOS)-containing neurons have been localized in various parts of the CNS. These neurons occur in the hypothalamus, mostly in the paraventricular and supraoptic nuclei and their axons project to the neural lobe of the pituitary gland.
V. Rettori, G. Canteros, S.M. McCann
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

RNAseq and targeted metabolomics implicate RIC8 in regulation of energy homeostasis, amino acid compartmentation, and asexual development in Neurospora crassa

mBio
Heterotrimeric G protein signaling pathways control growth and development in eukaryotes. In the multicellular fungus Neurospora crassa, the guanine nucleotide exchange factor RIC8 regulates heterotrimeric Gα subunits.
Monique Quinn, Alexander J. Carrillo, Lida Halilovic, Katherine A. Borkovich   +3 more
doaj   +1 more source

Structural Sampling of Glycan Interaction Profiles Reveals Mucosal Receptors for Fimbrial Adhesins of Enterotoxigenic Escherichia coli

Biology, 2013
Fimbriae are long, proteinaceous adhesion organelles expressed on the bacterial envelope, evolutionarily adapted by Escherichia coli strains for the colonization of epithelial linings. Using glycan arrays of the Consortium for Functional Glycomics (CFG),
Manfred Wuhrer, Julie Bouckaert, Stefan Oscarson, André M. Deelder, Yann Guérardel, Emeline Fabre, Johan D. M. Olsson, Manfred S. Weiss, Lieven Buts, Arjen R. de Boer, Emanuela Lonardi, Kristof Moonens   +11 more
doaj   +1 more source

Arginine Kinase Activates Arginine for Phosphorylation by Pyramidalization and Polarization

ACS Catalysis
Arginine phosphorylation plays numerous roles throughout biology. Arginine kinase (AK) catalyzes the delivery of an anionic phosphoryl group (PO3-) from ATP to a planar, trigonal nitrogen in a guanidinium cation. Density functional theory (DFT) calculations have yielded a model of the transition state (TS) for the AK-catalyzed reaction.
Falcioni, F., Molt, R.W., Jin, Y., Waltho, J.P., Hay, S., Richards, N.G.J., Blackburn, G.M.   +6 more
openaire   +4 more sources

Plasmid DNA delivery using fluorescein-labeled arginine-rich peptides [PDF]

, 2015
Arginine (Arg)-rich peptides exhibit an effective cell-penetrating ability and deliver membrane-impermeable compounds into cells. In the present study, three types of Arg-rich peptides, R9 containing nine Arg residues, (RRG)3 containing six Arg and three
Demizu, Yosuke, Kurihara, Masaaki, Tanaka, Masakazu, Yamashita, Hiroko, Oba, Makoto   +4 more
core   +1 more source

Effect of streptococcal arginine deiminase on the function of CD4⁺ and CD8⁺T lymphocytes

Медицинская иммунология
Arginine metabolism plays an important role in regulating the functions of immune cells in mammals. Pathogenic microbes use the mechanism of arginine depletion to suppress the immune response during infection.
E. A. Starikova, J. T. Mammedova, A. Ozhiganova, A. M. Lebedeva, T. A. Leveshko, L. A. Burova, I. V. Kudryavtsev   +6 more
doaj   +1 more source

Role of arginine and/or taurine in protection against gentamicin-induced nephrotoxicity in male and female rats

Journal of Medicine in Scientific Research, 2019
Background As a highly effective antibiotic, gentamicin is used in the treatment of serious and life-threatening gram-negative infections. L-arginine (2-amino-5-guanidino-pentanoic acid) has a protective role on renal failure that induced by gentamicin ...
Wafaa M Ismaeil, Amal H Emara
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source