Results 71 to 80 of about 843,121 (388)

Non-Histone Arginine Methylation by Protein Arginine Methyltransferases [PDF]

Current Protein & Peptide Science, 2020
Protein arginine methyltransferase (PRMT) enzymes play a crucial role in RNA splicing, DNA damage repair, cell signaling, and differentiation. Arginine methylation is a prominent posttransitional modification of histones and various non-histone proteins that can either activate or repress gene expression.
Ayad A. Al-Hamashi, Krystal Diaz, Rong Huang   +2 more
openaire   +2 more sources

Histone arginine methylation [PDF]

FEBS Letters, 2010
Arginine methylation is a common posttranslational modification (PTM). This type of PTM occurs on both nuclear and cytoplasmic proteins, and is particularly abundant on shuttling proteins. In this review, we will focus on one aspect of this PTM: the diverse roles that arginine methylation of the core histone tails play in regulating chromatin function.
Mark T. Bedford, Alessandra Di Lorenzo
openaire   +3 more sources

Development of Immune-Regulatory Pseudo-Protein-Coated Iron Oxide Nanoparticles for Enhanced Treatment of Triple-Negative Breast Tumor

Nanomaterials
Triple-negative breast cancer (TNBC) frequently evades immune recognition and elimination, resulting in an immunosuppressive microenvironment. The phagocytic activity of tumor-associated macrophages underscores the development of nanomaterials as a ...
Ying Ji, Juan Li, Li Ma, Zhijie Wang, Bochu Du, Hiu Yee Kwan, Zhaoxiang Bian, Chih-Chang Chu   +7 more
doaj   +1 more source

Nitric Oxide Deficiency in Mitochondrial Disorders: The Utility of Arginine and Citrulline

Frontiers in Molecular Neuroscience, 2021
Mitochondrial diseases represent a growing list of clinically heterogeneous disorders that are associated with dysfunctional mitochondria and multisystemic manifestations.
Mohammed Almannai, Mohammed Almannai, Ayman W. El-Hattab, Ayman W. El-Hattab   +3 more
doaj   +1 more source

I. Arginine

Biomedicine & Pharmacotherapy, 2002
L-Arginine (Arg) is classified as an essential amino acid for birds, carnivores and young mammals and a conditionally essential amino acid for adults. It is converted by arginase to L-ornithine, a precursor of polyamines and urea, which is important in the urea cycle.
H, Tapiero, G, Mathé, P, Couvreur, K D, Tew   +3 more
openaire   +2 more sources

Arginine Alters miRNA Expression Involved in Development and Proliferation of Rat Mammary Tissue

Animals, 2021
This study was designed to determine the effects of dietary arginine on development and proliferation in rat mammary tissue through changes in miRNA profiles. Twelve pregnant Wistar rats were allocated randomly to two groups.
Gang Zhou, Qiaoyun Xu, Feifan Wu, Mengzhi Wang, Lianmin Chen, Liangyu Hu, Jingwen Zhao, Juan J. Loor, Jun Zhang   +8 more
doaj   +1 more source

Proteomics profiling of arginine methylation defines PRMT5 substrate specificity

Science Signaling, 2019
Proteomics identifies target sites and substrates of the arginine methyltransferase PRMT5. Profiling PRMT5 The enzyme PRMT5 methylates arginine residues in target proteins to modify their function.
D. Musiani, Jabez Bok, Enrico Massignani, Liling Wu, Tommaso Tabaglio, M. Ippolito, A. Cuomo, U. Ozbek, Habiba Zorgati, Umesh Ghoshdastider, R. Robinson, E. Guccione, T. Bonaldi   +12 more
semanticscholar   +1 more source

Combination Therapy with Pyridoxine and Arginine Supplementations along with a Lysine-Restricted Diet in Individuals with Pyridoxine-Dependent Epilepsy: A Comprehensive Systematic Review

Current Developments in Nutrition
Background: Pyridoxine-dependent epilepsy (PDE) is identified as a rare neurometabolic disease marked by biallelic pathogenic mutations of the ALDH7A1 gene.
Ali Jafari, Mohammad Mehdi Abbasi, Hamid Abbasi, Sama Rahnemayan, Farnush Bakhshimoghaddam, Saeid Doaei   +5 more
doaj   +1 more source

Enzymes Catalyzing the TCA- and Urea Cycle Influence the Matrix Composition of Biofilms Formed by Methicillin-Resistant Staphylococcus aureus USA300

Microorganisms, 2018
In methicillin-sensitive Staphylococcus aureus (MSSA), the tricarboxylic acid (TCA) cycle is known to negatively regulate production of the major biofilm-matrix exopolysaccharide, PIA/PNAG. However, methicillin-resistant S.
Sarah De Backer, Julia Sabirova, Ines De Pauw, Henri De Greve, Jean-Pierre Hernalsteens, Herman Goossens, Surbhi Malhotra-Kumar   +6 more
doaj   +1 more source

ArgR is an essential local transcriptional regulator of the arcABC-operon in Streptococcus suis and crucial for biological fitness in acidic environment [PDF]

, 2011
Streptococcus suis is one of the most important pathogens in pigs and can also cause severe infections in humans. Despite its clinical relevance very little is known about the factors contributing to its virulence.
Benga, L., Fulde, M., Goethe, R., Greeff, A., de, Smith, H.E., Valentin-Weigand, P., Willenborg, J.   +6 more
core   +2 more sources