Claws, Disorder, and Conformational Dynamics of the C-terminal Region of Human Desmoplakin [PDF]
The Journal of Physical Chemistry B (2016), 2016 Multicellular organisms consist of cells that interact via elaborate adhesion complexes. Desmosomes are membrane-associated adhesion complexes that mechanically tether the cytoskeletal intermediate filaments (IFs) between two adjacent cells, creating a network of tough connections in tissues such as skin and heart.
arxiv +1 more source
Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel [PDF]
, 2014 Arginine methylation is a novel post-translational modification within the voltage-gated ion channel superfamily, including the cardiac sodium channel, Naᵥ1.5.
Beltran-Alvarez, Pedro +5 more
core +1 more source
Molecular Electroporation and the Transduction of Oligoarginines [PDF]
Phys. Biol. 7 (2010) 016001 (14pp), 2008 Certain short polycations, such as TAT and polyarginine, rapidly pass through the plasma membranes of mammalian cells by an unknown mechanism called transduction as well as by endocytosis and macropinocytosis. These cell-penetrating peptides (CPPs) promise to be medically useful when fused to biologically active peptides.
arxiv +1 more source
Autophagy maintains tumor growth through circulating arginine
Nature, 2018 Autophagy captures intracellular components and delivers them to lysosomes, where they are degraded and recycled to sustain metabolism and to enable survival during starvation1–5.
Laura Poillet-Perez +16 more
semanticscholar +1 more source
Proteomics profiling of arginine methylation defines PRMT5 substrate specificity
Science Signaling, 2019 Proteomics identifies target sites and substrates of the arginine methyltransferase PRMT5. Profiling PRMT5 The enzyme PRMT5 methylates arginine residues in target proteins to modify their function.
D. Musiani +12 more
semanticscholar +1 more source
Biomedicine & Pharmacotherapy, 2002 L-Arginine (Arg) is classified as an essential amino acid for birds, carnivores and young mammals and a conditionally essential amino acid for adults. It is converted by arginase to L-ornithine, a precursor of polyamines and urea, which is important in the urea cycle.
H, Tapiero +3 more
openaire +2 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Tailored second line therapy in asthmatic children with the arginine-16 genotype [PDF]
, 2012 The arginine-16 beta-2 receptor genotype confers increased susceptibility to exacerbations in asthmatic children taking regular long acting beta-2 agonists.
Aziz +27 more
core +1 more source
Can Arginine Help to Improve Milk Supply in Humans? It Does in Cows
Proceedings, 2023 Arginine can be metabolized into nitric oxide, polyamine, creatine, or agmatine, and each of those metabolites has several biological functions [...]
Luoyang Ding +7 more
doaj +1 more source
Arginine-Phosphate Salt Bridges Between Histones and DNA: Intermolecular Actuators that Control Nucleosome Architecture [PDF]
, 2014 Structural bioinformatics and van der Waals density functional theory are combined to investigate the mechanochemical impact of a major class of histone-DNA interactions, namely the formation of salt bridges between arginine residues in histones and phosphate groups on the DNA backbone.
arxiv +1 more source