Results 71 to 80 of about 844,163 (322)

ArgR is an essential local transcriptional regulator of the arcABC-operon in Streptococcus suis and crucial for biological fitness in acidic environment [PDF]

, 2011
Streptococcus suis is one of the most important pathogens in pigs and can also cause severe infections in humans. Despite its clinical relevance very little is known about the factors contributing to its virulence.
Benga, L., Fulde, M., Goethe, R., Greeff, A., de, Smith, H.E., Valentin-Weigand, P., Willenborg, J.   +6 more
core   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Dietary Supplementation with L-Citrulline Between Days 1 and 60 of Gestation Enhances Embryonic Survival in Lactating Beef Cows

Animals
Low fertility limits reproductive efficiency in cattle. This study was conducted with multiparous Brangus cows receiving dietary supplementation with or without L-citrulline [Cit; an immediate precursor of L-arginine (Arg)].
Kyler R. Gilbreath, Michael Carey Satterfield, Lan Zhou, Fuller W. Bazer, Guoyao Wu   +4 more
doaj   +1 more source

Zein Nanoparticles Containing Arginine-Phenylalanine-Based Surfactants: Stability, Antimicrobial and Hemolytic Activity

Nanomaterials, 2023
Although cationic surfactants have a remarkable antimicrobial activity, they present an intrinsic toxicity that discourages their usage. In this work novel zein nanoparticles loaded with arginine-phenylalanine-based surfactants are presented.
Lourdes Perez, Zakaria Hafidi, Aurora Pinazo, Maria Teresa García, Manuel Martín-Pastor, Francisco Fábio Oliveira de Sousa   +5 more
doaj   +1 more source

Proteomics profiling of arginine methylation defines PRMT5 substrate specificity

Science Signaling, 2019
Proteomics identifies target sites and substrates of the arginine methyltransferase PRMT5. Profiling PRMT5 The enzyme PRMT5 methylates arginine residues in target proteins to modify their function.
D. Musiani, Jabez Bok, Enrico Massignani, Liling Wu, Tommaso Tabaglio, M. Ippolito, A. Cuomo, U. Ozbek, Habiba Zorgati, Umesh Ghoshdastider, R. Robinson, E. Guccione, T. Bonaldi   +12 more
semanticscholar   +1 more source

Ocean acidification affects marine chemical communication by changing structure and function of peptide signalling molecules [PDF]

, 2016
Ocean acidification is a global challenge that faces marine organisms in the near future with a predicted rapid drop in pH of up to 0.4 units by the end of this century.
Adamo, Bode, Bopp, Briffa, Brown, Browne, Clements, Compton, Crothers, Darnell, Decho, Dodd, Fabry, Forward, Grimme, Grimme, Halgren, Hall-Spencer, Hardege, Hardege, Hay, Hayden, Haye, Hehre, Henry, Hunter, Jensen, Jensen, Jensen, Kim, Klamt, Kratt, Kutzelnigg, Leduc, Lemly, Lide, Lodewyk, McDonald, McNeil, Munday, Munday, Neese, Neese, Nilsson, O'Boyle, Perdew, Pettis, Piotto, Po, Pörtner, R Core Team, Reinsel, Reisert, Rittschof, Rittschof, Rittschof, Rittschof, Sklenář, Steiger, Tegtmeyer, Tierney, Vries, Weigend, Wishart, Wittmann, Wyatt, Wyatt, Wyatt, Zimmer, Zimmer-Faust   +69 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The Poly-Arginine Peptide R18D Interferes with the Internalisation of α-Synuclein Pre-Formed Fibrils in STC-1 Enteroendocrine Cells

Biomedicines, 2023
In Parkinson’s disease (PD), gut inflammation is hypothesised to contribute to α-synuclein aggregation, but gastrointestinal α-synuclein expression is poorly characterised.
Anastazja M. Gorecki, Holly Spencer, Bruno P. Meloni, Ryan S. Anderton   +3 more
doaj   +1 more source

Translating Metabolic Reprogramming into New Targets for Kidney Cancer. [PDF]

, 2017
In the age of bioinformatics and with the advent of high-powered computation over the past decade or so the landscape of biomedical research has become radically altered.
Abu Aboud, Omran, Weiss, Robert H
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source