Results 161 to 170 of about 115,664,573 (187)

Argininosuccinate synthase 1 and periportal gene expression in sonic hedgehog hepatocellular adenomas

Hepatology, 2018
Genetic alterations define different molecular subclasses of hepatocellular adenoma (HCA) linked with risk factors, histology and clinical behavior. Recently, Argininosuccinate Synthase 1 (ASS1), a major periportal protein, was proposed as a marker of ...
J. Nault, G. Couchy, S. Caruso, Léa Meunier, L. Caruana, E. Letouzé, S. Rebouissou, V. Paradis, J. Calderaro, J. Zucman-Rossi   +9 more
semanticscholar   +1 more source

Does Argininosuccinate Synthase 1 (ASS1) Immunohistochemistry Predict an Increased Risk of Hemorrhage for Hepatocellular Adenomas?

Applied immunohistochemistry & molecular morphology (Print), 2019
Supplemental Digital Content is available in the text. Hepatocellular adenomas (HCAs) often pursue an innocuous clinical course. Recent work has elucidated important subtypes of HCA and biomarkers to identify them, including HCA at an increased risk for ...
Heidi D. Lehrke, B. J. Van Treeck, D. Allende, L. Denham, Raul S. Gonzalez, R. Moreira, Taofic M. Mounajjed, B. Naini, R. Smoot, R. Zreik, Sarah M. Jenkins, Rondell P. Graham   +11 more
semanticscholar   +1 more source

Advances in the impact of ASS1 dysregulation on metabolic reprogramming of tumor cells.

Cellular Signalling
ASS1(argininosuccinate synthase 1) is a rate-limiting enzyme in the urea cycle, catalyzing the synthesis of argininosuccinate from citrulline and aspartate to ultimately produce arginine and support cellular metabolism.
Jiao-Jiao Xia, Wen-Jing Liu, Yue-Li Ni, Asif Shahzad, Kun Cui, Zhe Xu, Jin-Shan Zhang, Zhenyan Wei, Zhuoran Teng, Zhe Yang, Qiao Zhang   +10 more
semanticscholar   +1 more source

ASS1 Enhances Anoikis Resistance via AMPK/CPT1A-mediated Fatty Acid Metabolism in Ovarian Cancer.

Cancer Letters
Metastasis is the leading cause of death in ovarian cancer (OC), with anoikis resistance being a crucial step for detached OC cells survival. Despite extensive research, targeting anoikis resistance remians a challenge.
Xu Feng, Zhaodong Ji, Xiao-Xi Fan, Y. Kong, Yinjue Yu, Yang Shao, Jiao Meng, Xiaoyan Zhou, Ranran Tang, Gong Yang   +9 more
semanticscholar   +1 more source

Argininosuccinate Synthase 1 (ASS1) Deficiency Promotes Fibroblast Activation and Pulmonary Fibrosis

, 2021
Ji-Min Li, David C. Yang, J. Oldham, Angela L. Linderholm, N. Kenyon, Ching-Hsien Chen   +5 more
semanticscholar   +1 more source

Oncogenic KRAS induces arginine auxotrophy and confers a therapeutic vulnerability to SLC7A1 inhibition in non-small cell lung cancer.

Cancer Research
The urea cycle is frequently rewired in cancer cells to meet the metabolic demands of cancer. Elucidation of the underlying mechanism by which oncogenic signaling mediates urea cycle reprogramming could help identify targetable metabolic vulnerabilities.
X. Gai, Yingluo Liu, Xiaojing Lan, Luo-Yi Chen, T. Yuan, Jun Xu, Yi-Ze Li, Ying Zheng, Yiyang Yan, Liya Yang, Yi-Xian Fu, Shuai Tang, Siyuwei Cao, Xiaoyang Dai, Hong Zhu, M. Geng, Jian Ding, Cong-Ying Pu, Min Huang   +18 more
semanticscholar   +1 more source

Argininosuccinate synthase 1 (ASS1): A marker of unclassified hepatocellular adenoma and high bleeding risk

Hepatology, 2017
E. Henriet, Aya Abou Hammoud, J. Dupuy, B. Dartigues, Zakaria Ezzoukry, N. Dugot-Senant, T. Leste-Lasserre, N. Pallares-Lupon, M. Nikolski, B. le Bail, J. Blanc, C. Balabaud, P. Bioulac-Sage, A. Raymond, Frédéric Saltel   +14 more
semanticscholar   +1 more source

FRI-332 Pathological role of argininosuccinate synthase 1 in metabolic dysfunction-associated steatotic liver disease-related liver fibrosis

Journal of Hepatology
Yen-Tung Chen, L. Wirawan, Ming-Lung Yu, Ji-Ming Li   +3 more
semanticscholar   +1 more source

The Argininosuccinate Synthetase Can Differentially Regulate Nitric Oxide Synthase in Yellow Catfish Pelteobagrus fulvidraco

Fish and Shellfish Immunology, 2022
Haibo Jiang, Muzi Zhang
exaly  

Argininosuccinate Synthase as a Novel Biomarker for Inflammatory Conditions

Biomarkers, 2013
David R. Nelson, Thomas J George
exaly