Results 1 to 10 of about 5,002 (185)

Asymptomatic ASS1 Carriers With High Blood Citrulline Levels

Molecular Genetics & Genomic Medicine, 2022
Introduction Citrullinemia Type 1 (CTLN1) is an autosomal recessive disorder caused by variants in the ASS1 gene. This study intends to clarify the etiology of false positives in newborn screening for citrullinemia. Method Newborns who had elevated dried‐
Wuh-liang Hwu, Yin-Hsiu Chien, Ni-Chung Lee   +2 more
exaly   +4 more sources

ASS1 Facilitates T-ALL Progression via the Arginine-Mediated mTORC1/c-Myc Signaling Pathway [PDF]

Scientific Reports
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy arising from abnormal T-cell differentiation. Conventional treatment strategies remain suboptimal, and no effective targeted therapy is currently available.
Zijian Zhang, Xiyu Liu, Qifang Wu, Jianwei Liang, Yuan Zhao, Jiaqi Deng, Yuqing Wang, Qingrun Yu, Zishan Ye, Haichuan Zhu, Jian Lin   +10 more
exaly   +3 more sources

Evodiamine Inhibits Colorectal Cancer by Downregulating ASS1 via Wnt/β-Catenin/c-MYC Pathway to Block Arginine Synthesis [PDF]

Pharmaceuticals
Background: Argininosuccinate synthase 1 (ASS1), a key enzyme in arginine biosynthesis, is highly expressed in colorectal cancer (CRC) and promotes cancer progression, making it a potential therapeutic target.
Huimin Wang, Hao Deng, Jiaming He, Jing Ma, Yunying Li, Haoyue Lv, Jianhua Ran, Dilong Chen, Jing Li   +8 more
doaj   +3 more sources

Argininosuccinate synthase 1 (ASS1) orchestrates arginine metabolism and ornithine production to modulate CHIKV infection [PDF]

Journal of Virology
Viruses reprogram the host metabolic machinery to ensure a continuous supply of macromolecules and energy for their own survival. Important cellular pathways are impacted during infection, resulting in changes in key metabolic precursors that influence ...
Nimisha Mishra, Mothe Sravya, Sonali Hanjankar, Anjali Singh, Yash Chaudhary, Ranjan Kumar Nanda, Sujatha Sunil   +6 more
doaj   +2 more sources

L-Citrulline Attenuates Keratinocyte Activation and Modulates ASS1 Expression in Psoriasis-Like Mice [PDF]

Drug Design, Development and Therapy
Shuang Yang,1 Yang Chen,2 Zhuli Li,1 Jinlin Liu,3 Yanteng Zhao,1 Xiaoyan Zhang,1 Qiankun Yang11Department of Blood Transfusion, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China; 2Department of Cardiology, The ...
Yang S, Chen Y, Li Z, Liu J, Zhao Y, Zhang X, Yang Q   +6 more
doaj   +2 more sources

Extracellular vesicles derived by hypoxic preconditioned EPCs attenuated atherosclerosis by suppressing ferroptosis via regulating arginine metabolism [PDF]

Redox Biology
Endothelial progenitor cells (EPCs) derived extracellular vesicles (EVs) are involved in maintaining vascular homeostasis, while effects of hypoxic preconditioned EPCs-derived EVs (Hy-EVs) on atherosclerosis (AS) remain unclear.
Xing Luo, Xinxin Zhu, Yuwu Chen, Yiyuan Guo, Biyi Xu, Junke Mou, Mengyang Wang, Qishuo Gu, Qianhui Sun, Ying Lv, Xingtao Huang, Ming Zeng, Boling Yi, Xiaolin Liu, Xiaoxuan Bai, Cheng Fang, Ji Li, Bo Yu, Haibo Jia   +18 more
doaj   +2 more sources

The HKDC1-ASS1-ACSBG2 axis reprograms lipid metabolism to drive therapeutic resistance in hepatocellular carcinoma [PDF]

Journal of Translational Medicine
Background Hepatocellular carcinoma (HCC) is a lethal malignancy characterized by profound metabolic reprogramming, notably aberrant lipid metabolism. Current therapeutic strategies offer limited efficacy, highlighting the critical need to identify its ...
Xiangyu Ling, Wenhu Zhao, Kuan Li, Litao Liang, Wenbo Jia, Jinyi Wang, Yanzhi Feng, Chao Xu, Qingpeng Lv, Zhiwen Feng, Deming Zhu, Lianbao Kong, Wenzhou Ding   +12 more
doaj   +2 more sources

ZFPL1 Promotes Colorectal Cancer Progression by Stabilizing ASS1 to Drive the Urea Cycle and M2 Macrophage‐Mediated Metastatic Colonization [PDF]

Advanced Science
Colorectal cancer (CRC) progression is driven by diverse molecular mechanisms, underscoring the urgent need for novel therapeutic strategies, especially for liver metastases. Through an integrated analysis of multiple single‐cell RNA sequencing databases,
Xiangjun Qian, Chenxi Xie, Beilin Zhang, Hengsong Cao, Zhengqing Lu, Li Liu, Shipeng Dai, Xiaoqian Wang, Xiaokai Zhang, Feng Han, Yanyan Liu, Haibo Yu, Weiwei Tang, Jinxue Zhou, Xiaopei Hao   +14 more
doaj   +2 more sources

A pan-cancer analysis of the role of argininosuccinate synthase 1 in human tumors

Frontiers in Oncology, 2023
AimThere is accumulating evidence indicating that ASS1 is closely related to tumors. No pan-cancer analysis of ASS1 was available.MethodsHere we explored the gene expression and survival analysis of ASS1 across thirty-three tumors based on the datasets ...
Qiang Ding, Qiang Ding, Qiang Ding, Ruiqi Li, Ruiqi Li, Ruiqi Li, Qingming Wang, Qingming Wang, Qingming Wang, Li Yu, Li Yu, Li Yu, Fuming Zi, Fuming Zi, Fuming Zi   +14 more
doaj   +1 more source

Argininosuccinate synthase 1 suppresses tumor progression through activation of PERK/eIF2α/ATF4/CHOP axis in hepatocellular carcinoma

Journal of Experimental & Clinical Cancer Research, 2021
Background Hepatocellular carcinoma (HCC) is one of the most common malignant cancers worldwide, and liver cancer has increased in mortality due to liver cancer because it was detected at an advanced stages in patients with liver dysfunction, making HCC ...
Sanghwa Kim, Minji Lee, Yeonhwa Song, Su-Yeon Lee, Inhee Choi, I-Seul Park, Jiho Kim, Jin-sun Kim, Kang mo Kim, Haeng Ran Seo   +9 more
doaj   +1 more source