Results 31 to 40 of about 5,002 (185)

Clinical Validation of Plasma p-217tau in Neurological Diseases. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Kawarabayashi T, Nakamura T, Takahashi R, Ueda T, Kinoshita S, Uchida C, Sugawara T, Hashimoto K, Ishizawa K, Amari M, Kasahara H, Ikeda Y, Takatama M, Shoji M.   +13 more
europepmc   +2 more sources

A novel Romani microdeletion variant in the promoter sequence of ASS1 causes citrullinemia type I

Molecular Genetics and Metabolism Reports, 2020
Background: Citrullinemia type I (CTLN1, MIM #215700) is an autosomal recessive urea cycle disorder caused by deficiency of argininosuccinate synthase (ASS).
Eri Imagawa, George A. Diaz, Kimihiko Oishi   +2 more
doaj   +1 more source

Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis

Cell Death and Disease, 2021
The epithelial signaling pathways involved in damage and regeneration, and neoplastic transformation are known to be similar. We noted upregulation of argininosuccinate synthetase (ASS1) in hyperproliferative intestinal epithelium. Since ASS1 leads to de
Jonathan H. M. van der Meer, Ruben J. de Boer, Bartolomeus J. Meijer, Wouter L. Smit, Jacqueline L. M. Vermeulen, Sander Meisner, Manon van Roest, Pim J. Koelink, Evelien Dekker, Theodorus B. M. Hakvoort, Jan Koster, Lukas J. A. C. Hawinkels, Jarom Heijmans, Eduard A. Struijs, Marja A. Boermeester, Gijs R. van den Brink, Vanesa Muncan   +16 more
doaj   +1 more source

Defects in intratumoral arginine metabolism attenuate the replication and therapeutic efficacy of oncolytic myxoma virus

Journal for ImmunoTherapy of Cancer, 2023
Background Arginine (Arg) is a semiessential amino acid whose bioavailability is required for the in vitro replication of several oncolytic viruses. In vivo, Arg bioavailability is regulated by a combination of dietary intake, protein catabolism, and ...
Eric Bartee, Parker Dryja, Heather D Curtsinger, Mee Y Bartee   +3 more
doaj   +1 more source

Inositol possesses antifibrotic activity and mitigates pulmonary fibrosis

Respiratory Research, 2023
Background Myo-inositol (or inositol) and its derivatives not only function as important metabolites for multiple cellular processes but also act as co-factors and second messengers in signaling pathways. Although inositol supplementation has been widely
Ji-Min Li, Wen-Hsin Chang, Linhui Li, David C. Yang, Ssu-Wei Hsu, Nicholas J. Kenyon, Ching-Hsien Chen   +6 more
doaj   +1 more source

A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma [PDF]

, 2023
Background Pegylated arginine deiminase (ADI-PEG20; pegargiminase) depletes arginine and improves survival outcomes for patients with argininosuccinate synthetase 1 (ASS1)-deficient malignant pleural mesothelioma (MPM).
Hallden, G, Szlosarek, PW, Pavlyk, I, Chelala, C, Cutts, R, Feng, S, Bomalaski, J, Phillips, MM, Berry, JS, Allen, M, Ghazaly, E, Carpentier, J, Sheaff, M, Steele, J, Balkwill, F, Nattress, C   +15 more
core   +1 more source

ASS1 and ASL suppress growth in clear cell renal cell carcinoma via altered nitrogen metabolism

Cancer & Metabolism, 2021
Background Kidney cancer is a common adult malignancy in the USA. Clear cell renal cell carcinoma (ccRCC), the predominant subtype of kidney cancer, is characterized by widespread metabolic changes.
Sanika Khare, Laura C. Kim, Graham Lobel, Paschalis-Thomas Doulias, Harry Ischiropoulos, Itzhak Nissim, Brian Keith, M. Celeste Simon   +7 more
doaj   +1 more source

Synergistic effects of L-arginine and argininosuccinate synthetase 1 in inducing apoptosis in hepatocellular carcinoma [PDF]

Journal of Liver Cancer
Backgrounds/Aims Hepatocellular carcinoma (HCC) is a malignant cancer with an increasing incidence worldwide. Although numerous efforts have been made to identify effective therapies for HCC, current strategies have limitations. We present a new approach
Jin Sun Kim, Won-Mook Choi, Ha-Il Kim, Sung Won Chung, Jonggi Choi, Danbi Lee, Kang Mo Kim   +6 more
doaj   +1 more source

Clinical characteristics of patients with suspected Alzheimer’s disease within a CSF Aß-ratio grey zone

Neurological Research and Practice, 2023
Background The AT(N) research framework for Alzheimer's disease (AD) remains unclear on how to best deal with borderline cases. Our aim was to characterise patients with suspected AD with a borderline Aß1-42/Aß1-40 ratio in cerebrospinal fluid.
Dariia Yosypyshyn, Domantė Kučikienė, Inez Ramakers, Jörg B. Schulz, for the Alzheimer’s Disease Neuroimaging Initiative, Kathrin Reetz, Ana Sofia Costa   +6 more
doaj   +1 more source

Acid-Induced Downregulation of ASS1 Contributes to the Maintenance of Intracellular pH in Cancer [PDF]

Cancer Research, 2019
Abstract Downregulation of the urea cycle enzyme argininosuccinate synthase (ASS1) by either promoter methylation or by HIF1α is associated with increased metastasis and poor prognosis in multiple cancers.
Alon Silberman, Omer Goldman, Odeya Boukobza Assayag, Adi Jacob, Shiran Rabinovich, Lital Adler, Joo Sang Lee, Rom Keshet, Alona Sarver, Julia Frug, Noa Stettner, Sivan Galai, Erez Persi, Keren Bahar Halpern, Yehudit Zaltsman-Amir, Ben Pode-Shakked, Raya Eilam, Yair Anikster, Sandesh C.S. Nagamani, Igor Ulitsky, Eytan Ruppin, Ayelet Erez   +21 more
openaire   +2 more sources