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Implications of Porphyromonas gingivalis peptidyl arginine deiminase and gingipain R in human health and diseases [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Porphyromonas gingivalis is a major pathogenic bacterium involved in the pathogenesis of periodontitis. Citrullination has been reported as the underlying mechanism of the pathogenesis, which relies on the interplay between two virulence factors of the ...
Yoke Chan Chow +8 more
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Bibliometric and visualization analysis of arginine deiminase research from 2006 to 2025: trends, collaboration networks and emerging frontiers [PDF]
Frontiers in ImmunologyBackgroundPeptidylarginine Deiminase/Protein Arginine Deiminase (PAD/PADI) are a family of enzymes that catalyze protein citrullination, converting arginine residues to citrulline residues in a calcium-dependent manner. The net loss of positive charge of
Songtao Jiang +9 more
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Streptococcal Arginine Deiminase Inhibits T Lymphocyte Differentiation In Vitro [PDF]
Microorganisms, 2023 Pathogenic microbes use arginine-metabolizing enzymes as an immune evasion strategy. In this study, the impact of streptococcal arginine deiminase (ADI) on the human peripheral blood T lymphocytes function in vitro was studied.
Eleonora A. Starikova +9 more
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Arginine metabolism and the role of arginine deiminase-producing microorganisms in kimchi fermentation [PDF]
Heliyon, 2022 In this study, we evaluated the correlation between the arginine deiminase (ADI) pathway and nitrogen cycle during cabbage kimchi fermentation. Nitrite used as a food additive can be converted to carcinogenic N-nitroso compounds via reactions with ...
Sera Jung, Ji Yoon Chang, Jong-Hee Lee
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Heterogeneous lineage-specific arginine deiminase expression within dental microbiome species [PDF]
Microbiology SpectrumArginine catabolism by the bacterial arginine deiminase system (ADS) has anticariogenic properties through the production of ammonia, which modulates the pH of the oral environment.
Allison E. Mann +5 more
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Инфекция и иммунитет, 2021 Arginine deiminase is one of three enzymes constituting the arginine deiminase system in bacteria. It was demonstrated that arginine deiminase exerts anti-proliferative effects on some primary and immortalized mouse and human cells.
E. A. Starickova +5 more
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Медицинская иммунология, 2021 Numerous pathogens express arginine deiminase, an enzyme that catalyzes the hydrolysis of L-arginine in a chain of biochemical reactions aimed at the synthesis of ATP in bacterial cells. L-arginine is a semi-essential, proteinogenic amino acid that plays
E. A. Starikova +5 more
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Molecules, 2021 The use of arginine deiminase (ADI) for arginine depletion therapy is an attractive anticancer approach. Combination strategies are needed to overcome the resistance of severe types of cancer cells to this monotherapy.
Zhiying Huang, Haifeng Hu
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Regulation of glycolysis and cancer cell proliferation by PKM2 citrullination
Molecular & Cellular Oncology, 2021 Conversion of peptidyl-arginine to peptidyl citrulline, known as citrullination, is a post-translational protein modification catalyzed by the PADI (Protein Arginine Deiminase) family of enzymes. PADI1 and PADI3 catalyze citrullination of arginine 106 in
Sébastien Coassolo, Irwin Davidson
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Медицинская иммунология, 2017 There is a growing body of data about the cytopathic effect of bacterial arginine deiminase on human endothelial cells, but the precise mechanisms of endothelial dysfunction caused by the activity of the enzyme remain poorly understood.
E. A. Starikova +5 more
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