Results 41 to 50 of about 10,357 (212)

Design and Production of Arginine Deiminase-Azurin Recombinant Fusion Protein from Pseudomonas aeruginosa and its Confirmation by Western Blot

Novelty in Biomedicine, 2020
Background: Pseudomonas aeruginosa is a common Gram-negative, rod-shaped bacterium that has a unique genome that allowed the bacteria to produce various enzymes and proteins.
Mina Hadi, Mona Ghazi, Parvaneh Saffarian, Bahareh Hajikhani   +3 more
doaj   +1 more source

Synthesis and characterization of ZnS quantum dots and application for development of arginine biosensor

Sensing and Bio-Sensing Research, 2017
Arginine deiminase co-immobilized with ZnS QDs coupled micro-disk was applied for the sensing of arginine in real and spiked fruit samples. Intracellular arginine deiminase from Lactococcus lactis MTCC 460 was partially purified by ammonium sulphate ...
Neelam Verma, Ashish Kumar Singh, Nancy Saini   +2 more
doaj   +1 more source

Mucoadhesive Buccal Films for Local Delivery of Lactobacillus brevis

Pharmaceutics, 2020
The aim of this work was to prepare mucoadhesive buccal films for local release of Lactobacillus brevis CD2, which shows interesting anti-inflammatory properties due to its high levels of arginine deiminase.
Angela Abruzzo, Beatrice Vitali, Francesca Lombardi, Luca Guerrini, Benedetta Cinque, Carola Parolin, Federica Bigucci, Teresa Cerchiara, Catia Arbizzani, Maria Caterina Gallucci, Barbara Luppi   +10 more
doaj   +1 more source

The arginine deaminase system plays distinct roles in Borrelia burgdorferi and Borrelia hermsii.

PLoS Pathogens, 2022
Borrelia species are amino acid auxotrophs that utilize di- and tri- peptides obtained through their oligopeptide transport system to supply amino acids for replicative growth during their enzootic cycles.
Crystal L Richards, Sandra J Raffel, Sébastien Bontemps-Gallo, Daniel P Dulebohn, Tessa C Herbert, Frank C Gherardini   +5 more
doaj   +1 more source

Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy

BMC Cancer, 2020
Background Based on its low toxicity, arginine starvation therapy has the potential to cure malignant tumors that cannot be treated surgically. The Arginine deiminase (ADI) gene has been identified to be an ideal cancer-suppressor gene.
Qingyuan Feng, Xuzhao Bian, Xuan Liu, Ying Wang, Huiting Zhou, Xiaojing Ma, Chunju Quan, Yi Yao, Zhongliang Zheng   +8 more
doaj   +1 more source

Catabolic Ornithine Carbamoyltransferase Activity Facilitates Growth of Staphylococcus aureus in Defined Medium Lacking Glucose and Arginine

mBio, 2022
Previous studies have found that arginine biosynthesis in Staphylococcus aureus is repressed via carbon catabolite repression (CcpA), and proline is used as a precursor. Unexpectedly, however, robust growth of S.
Itidal Reslane, Cortney R. Halsey, Amanda Stastny, Barbara J. Cabrera, Jongsam Ahn, Dhananjay Shinde, Madeline R. Galac, Margaret F. Sladek, Fareha Razvi, McKenzie K. Lehman, Kenneth W. Bayles, Vinai C. Thomas, Luke D. Handke, Paul D. Fey   +13 more
doaj   +1 more source

Citrullination of Proteins as a Specific Response Mechanism in Plants

Frontiers in Plant Science, 2021
Arginine deimination, also referred to as citrullination of proteins by L-arginine deiminases, is a post-translational modification affecting histone modifications, epigenetic transcriptional regulation, and proteolysis in animals but has not been ...
Claudius Marondedze, Claudius Marondedze, Claudius Marondedze, Giuliano Elia, Ludivine Thomas, Aloysius Wong, Aloysius Wong, Chris Gehring, Chris Gehring   +8 more
doaj   +1 more source

Structural Insight into Arginine Degradation by Arginine Deiminase, an Antibacterial and Parasite Drug Target [PDF]

Journal of Biological Chemistry, 2004
l-Arginine deiminase (ADI) catalyzes the irreversible hydrolysis of arginine to citrulline and ammonia. ADI is involved in the first step of the most widespread anaerobic route of arginine degradation. ADI, missing in high eukaryotes, is a potential antimicrobial and antiparasitic drug target.
Herzberg, O, Howard, A, Lim, K, Sarikaya, ELİF, Kulakova, L, Galkin, A   +5 more
openaire   +3 more sources

Identification and characterization of two temperature-induced surface-associated proteins of Streptococcus suis with high homologies to members of the arginine deiminase system of Streptococcus pyogenes

, 2002
The present study was performed to identify stress-induced putative virulence proteins of Streptococcus suis. For this, protein expression patterns of streptococci grown at 32, 37, and 42°C were compared by one- and two-dimensional gel electrophoresis ...
Gruening, P., Smith, H.E., Winterhoff, N., Valentin-Weigand, P., Goethe, R., Kalisz, H., Rohde, M.   +6 more
core   +1 more source

Intracellular Delivery of Recombinant Arginine Deiminase (rADI) by Heparin-Binding Hemagglutinin Adhesion Peptide Restores Sensitivity in rADI-Resistant Cancer Cells

, 2017
Recombinant arginine deiminase (rADI) has been used in clinical trials for arginine-auxotrophic cancers. However, the emergence of rADI resistance, due to the overexpression of argininosuccinate synthetase (AS), has introduced an obstacle in its clinical
林慧玲;沈麗娟, Wu, Fe-Lin Lin;Yeh, Tzyy-Harn;Chen, Ying-Luen;Chiu, Yu-Chin;Cheng, Ju-Chen;Wei, Ming-Feng;Shen, Li-Jiuan   +1 more
core   +1 more source