Results 21 to 30 of about 10,357 (212)

Structural characterization of the enzymes composing the arginine deiminase pathway in Mycoplasma penetrans. [PDF]

PLoS ONE, 2012
The metabolism of arginine towards ATP synthesis has been considered a major source of energy for microorganisms such as Mycoplasma penetrans in anaerobic conditions.
Pablo Gallego, Raquel Planell, Jordi Benach, Enrique Querol, Josep A Perez-Pons, David Reverter   +5 more
doaj   +2 more sources

Multilevel Approach for the Treatment of Giardiasis by Targeting Arginine Deiminase [PDF]

International Journal of Molecular Sciences, 2021
Giardiasis represents a latent problem in public health due to the exceptionally pathogenic strategies of the parasite Giardia lamblia for evading the human immune system. Strains resistant to first-line drugs are also a challenge. Therefore, new antigiardial therapies are urgently needed. Here, we tested giardial arginine deiminase (GlADI) as a target
Cynthia Fernández-Lainez, Ignacio de la Mora-de la Mora, Itzhel García-Torres, Sergio Enríquez-Flores, Luis Flores-López, Pedro Gutiérrez-Castrellón, Lilian Yépez-Mulia, Felix Matadamas-Martínez, Paul de Vos, Gabriel López-Velázquez   +9 more
openaire   +4 more sources

Pegylated arginine deiminase: a novel anticancer enzyme agent [PDF]

Expert Opinion on Investigational Drugs, 2006
Pegylated arginine deiminase (ADI-PEG20) is a novel anticancer enzyme that produces depletion of arginine, which is a nonessential amino acid in humans. Certain tumours, such as malignant melanoma and hepatocellular carcinoma, are auxotrophic for arginine.
Lynn, Feun, Niramol, Savaraj
openaire   +3 more sources

A protocol to induce systemic autophagy and increase energy metabolism in mice using PEGylated arginine deiminase

STAR Protocols, 2022
Summary: Obesity is a prevalent metabolic disorder worldwide. Here, we describe a comprehensive protocol using pegylated arginine deiminase (ADI-EPG 20) to apply the concept that arginine depletion induces systemic autophagy to drive whole-body energy ...
Yiming Zhang, Brian J. DeBosch
doaj   +3 more sources

Effect of streptococcal arginine deiminase on the function of CD4⁺ and CD8⁺T lymphocytes

Медицинская иммунология
Arginine metabolism plays an important role in regulating the functions of immune cells in mammals. Pathogenic microbes use the mechanism of arginine depletion to suppress the immune response during infection.
E. A. Starikova, J. T. Mammedova, A. Ozhiganova, A. M. Lebedeva, T. A. Leveshko, L. A. Burova, I. V. Kudryavtsev   +6 more
doaj   +2 more sources

Salt Stress Induces Imbalanced ADI Pathway Gene Expressions in Pediococcus acidilactici Drives Citrulline Accumulation as an Ethyl Carbamate Precursor in Soy Sauce

Food Bioengineering
Citrulline is the main precursor of a carcinogen compound ethyl carbamate (EC) in soy sauce. Accumulation of citrulline is mainly related to metabolism of arginine by Pediococcus acidilactici via the arginine deiminase (ADI) pathway during soy sauce ...
Xiaodie Chen, Jiran Zhang, Haoran Chen, Fang Fang   +3 more
doaj   +2 more sources

Convergent evolution of the arginine deiminase pathway: the ArcD and ArcE arginine/ornithine exchangers [PDF]

MicrobiologyOpen, 2016
The arginine deiminase (ADI) pathway converts L-arginine into L-ornithine and yields 1 mol of ATP per mol of L-arginine consumed. The L-arginine/L-ornithine exchanger in the pathway takes up L-arginine and excretes L-ornithine from the cytoplasm. Analysis of the genomes of 1281 bacterial species revealed the presence of 124 arc gene clusters encoding ...
Noens, Elke E E, Lolkema, Juke S
openaire   +4 more sources

Heterogeneous lineage-specific arginine deiminase expression within dental microbiome species [PDF]

Microbiology Spectrum
Arginine catabolism by the bacterial arginine deiminase system (ADS) has anticariogenic properties through the production of ammonia, which modulates the pH of the oral environment.
Allison E. Mann, Brinta Chakraborty, Lauren M. O'Connell, Marcelle M. Nascimento, Robert A. Burne, Vincent P. Richards   +5 more
doaj   +2 more sources

Purification and characterization of arginine deiminase from Klebsiella pneumoniae

Medical Journal of Babylon
Background and Objectives: This study was aimed to characterize arginine deiminase (ADI) purified from Klebsiella pneumoniae in vitro. Materials and Methods: Precipitation with 70% saturated ammonium sulphate, ion exchange chromatography with a DEAE ...
Taif Hussien Alameedy, Mohammed Abdullah Jebor   +1 more
doaj   +2 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source