Bench-to-Bedside Studies of Arginine Deprivation in Cancer [PDF]
Molecules, 2023 Arginine is a semi-essential amino acid which becomes wholly essential in many cancers commonly due to the functional loss of Argininosuccinate Synthetase 1 (ASS1).
Peter Szlosarek, Iuliia Pavlyk
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Arginine Deprivation in SCLC: Mechanisms and Perspectives for Therapy [PDF]
Lung Cancer: Targets and Therapy, 2022 Joséphine Carpentier,1 Iuliia Pavlyk,1 Uma Mukherjee,2 Peter E Hall,2 Peter W Szlosarek1,2 1Centre for Cancer Biomarkers and Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK; 2Department of Medical Oncology ...
Peter E Hall +2 more
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Arginine deprivation: a potential therapeutic for cancer cell metastasis? A review [PDF]
Cancer Cell International, 2020 Arginine is a semi essential amino acid that is used in protein biosynthesis. It can be obtained from daily food intake or synthesized in the body through the urea cycle using l-citrulline as a substrate. Arginine has a versatile role in the body because
Houssam Al-Koussa +4 more
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p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake [PDF]
Cell Reports, 2019 Summary: Cancer cells heavily depend on the amino acid glutamine to meet the demands associated with growth and proliferation. Due to the rapid consumption of glutamine, cancer cells frequently undergo glutamine starvation in vivo.
Haiqing Li, Thai Q Tran, Mei Kong
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Argininosuccinate synthase 1, arginine deprivation therapy and cancer management [PDF]
Frontiers in Pharmacology, 2022 Metabolic reprogramming is an emerging hallmark of tumor cells. In order to survive in the nutrient-deprived environment, tumor cells rewire their metabolic phenotype to provide sufficient energy and build biomass to sustain their transformed state and ...
Naihui Sun, Xing Zhao
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Therapeutic Potential of Arginine Deprivation Therapy for Gliomas: A Systematic Review of the Existing Literature [PDF]
Frontiers in PharmacologyBackgroundArginine deprivation therapy (ADT) hinders glioma cells’ access to nutrients by reducing peripheral blood arginine, showing great efficacy in various studies, which suggests it as a potentially promising treatment for glioma.
Yuji Wang, Yanjie Lan, Yuxiao Chen
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GCN2-SLC7A11 axis coordinates autophagy, cell cycle and apoptosis and regulates cell growth in retinoblastoma upon arginine deprivation [PDF]
Cancer & MetabolismBackground Arginine deprivation was previously shown to inhibit retinoblastoma cell proliferation and induce cell death in vitro. However, the mechanisms by which retinoblastoma cells respond to arginine deprivation remain to be elucidated.
Dan Wang +6 more
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Inhibition of Tumor Microenvironment-Driven JAK-STAT Signaling Enhances Response to Arginine Deprivation Therapy in Triple-Negative Breast Cancer [PDF]
CellsArgininosuccinate synthetase 1 (ASS1) expression and arginine availability are key metabolic determinants that influence tumor fitness and regulate immune interactions within the tumor microenvironment (TME).
Hila Tishler +28 more
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Preclinical evidence of a direct pro-survival role of arginine deprivation in multiple myeloma [PDF]
Frontiers in Oncology, 2022 Multiple myeloma grows by establishing multiple interactions with bone marrow cells. These include expansion of myeloid-derived suppressor cells, which drive immunoevasion via mechanisms that include arginase-1-driven depletion of L-arginine, thus ...
Matteo Trudu +11 more
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Etoposide-induced protein 2.4 homolog promotes argininosuccinate synthase 1 and cancer cell survival upon arginine deprivation [PDF]
Cellular & Molecular Biology LettersBackground Arginine auxotrophy has been reported in a subset of cancers with inherently defective de novo arginine synthesis. However, the use of arginine deprivation therapy seems to be unequally effective, partially owing to the resistance acquired by ...
Vu T. A. Vo +4 more
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