Innate and adaptive resistance mechanisms to arginine deprivation therapies in sarcoma and other cancers. [PDF]
Cancer Drug Resist, 2019 Many cancers lack functional expression of the enzyme argininosuccinate synthetase 1 (ASS1) that is necessary for synthesis of L-arginine. These cancers must import arginine for survival and growth, and this reliance can be targeted by arginine-degrading
Rogers LC, Van Tine BA.
europepmc +2 more sources
Journal of Ovarian Research, 2021 Ovarian carcinoma is the second most common malignancy of the female reproductive system and the leading cause of death from female reproductive system malignancies.
Nour El-Mais +4 more
doaj +1 more source
Arginine metabolism: a potential target in pancreatic cancer therapy
Chinese Medical Journal, 2021 . Pancreatic ductal adenocarcinoma (PDAC) is an extremely malignant disease, which has an extremely low survival rate of
Jin-Shou Yang +5 more
doaj +1 more source
Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis. [PDF]
PLoS Genetics, 2015 Besides being building blocks for protein synthesis, amino acids serve a wide variety of cellular functions, including acting as metabolic intermediates for ATP generation and for redox homeostasis.
Xiaohu Tang +8 more
doaj +1 more source
Біологічні студії, 2022 Background. Neuroblastoma is a malignant tumor of the sympathetic nervous system common in early childhood. Autophagy is manifested in neuroblastoma cells at basal levels, but is often upregulated in cells of the aggressive neuroblastoma forms.
Y. V. Nishtuk +2 more
doaj +1 more source
L-arginine deprivation impairs Leishmania major-specific T-cell responses. [PDF]
, 2009 The amino acid L-arginine plays a crucial role in the regulation of immune responses. We have recently shown that uncontrolled replication of Leishmania parasites at the site of pathology correlates with high levels of arginase activity in nonhealing ...
Markus Munder +7 more
core +1 more source
REM sleep deprivation induces endothelial dysfunction and hypertension in middle-aged rats: Roles of the eNOS/NO/cGMP pathway and supplementation with L-arginine. [PDF]
PLoS ONE, 2017 Sleep loss can induce or aggravate the development of cardiovascular and cerebrovascular diseases. However, the molecular mechanism underlying this phenomenon is poorly understood.
Jiaye Jiang +6 more
doaj +1 more source
Differential impact of L-arginine deprivation on the activation and effector functions of T cells and macrophages. [PDF]
, 2008 The metabolism of the amino acid L-arginine is emerging as a crucial mechanism for the regulation of immune responses. Here, we characterized the impact of L-arginine deprivation on T cell and macrophage (MPhi) effector functions: We show that whereas L ...
Corset, C +20 more
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Sensing Host Arginine Is Essential for
mBio, 2020 Arginine homeostasis in lysosomes is critical for the growth and metabolism of mammalian cells. Phagolysosomes of macrophages are the niche where the parasitic protozoan Leishmania resides and causes human leishmaniasis.
Adele Goldman-Pinkovich +13 more
doaj +1 more source
Effect of combined arginase and nitric oxide donor treatment on normal and leukemic cells in vitro
Біологічні студії, 2016 Arginine deprivation has been recently suggested as a therapeutic approach against difficult to cure blood cancers. Herein, we investigated for the first time the combined effect of exogenous nitric oxide (NO) donor and recombinant human arginase (rhARG)
O. I. Chen +6 more
doaj +1 more source