An Arginine Deprivation Response Pathway Is Induced in Leishmania during Macrophage Invasion. [PDF]
PLoS Pathogens, 2016 Amino acid sensing is an intracellular function that supports nutrient homeostasis, largely through controlled release of amino acids from lysosomal pools.
Adele Goldman-Pinkovich +10 more
doaj +14 more sources
Influence of arginine metabolites on human tumor cell viability upon arginine deprivation in vitro
Біологічні студії, 2011 In human organism arginine is necessary not only for protein synthesis but it also serves as a precursor for a number of important biologically active substances that influence cell growth and viability. These substances include such arginine metabolites
Y. V. Kurlishchuk +3 more
doaj +4 more sources
Arginine deprivation therapy for malignant melanoma [PDF]
Clinical Pharmacology: Advances and Applications, 2012 Jung-Ki Yoon,1,2 Arthur E Frankel,3 Lynn G Feun,4 Suhendan Ekmekcioglu,1 Kevin B Kim11Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 2Hwasung Public Health Center, Hwasung, South ...
Yoon JK +4 more
doaj +8 more sources
Unlocking the Potential of Arginine Deprivation Therapy: Recent Breakthroughs and Promising Future for Cancer Treatment [PDF]
International Journal of Molecular Sciences, 2023 Arginine is a semi-essential amino acid that supports protein synthesis to maintain cellular functions. Recent studies suggest that arginine also promotes wound healing, cell division, ammonia metabolism, immune system regulation, and hormone ...
Chau-Ting Yeh, Ming-Wei Lai
exaly +3 more sources
The effect of arginine supplementation following sleep deprivation on carbohydrate and fat metabolism, balance and fatigue index in female athlete students [PDF]
Sport Sciences and Health Research, 2021 Introduction: Sleep deprivation is one of common phenomena in athletes. The aim of the present study was to investigate the influence of arginine supplementation following sleep deprivation on carbohydrate and fat metabolism, balance and fatigue index in
Morteza Taheri +2 more
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Molecular CellMany types of human cancers suppress the expression of argininosuccinate synthase 1 (ASS1), a rate-limiting enzyme for arginine production. Although dependency on exogenous arginine can be harnessed by arginine-deprivation therapies, the impact of ASS1 suppression on the quality of the tumor proteome is unknown.
Esther A Zaal +2 more
exaly +7 more sources
Arginine deprivation in cancer therapy
Current Opinion in Clinical Nutrition and Metabolic Care, 2015 There has been an increased and renewed interest in metabolic therapy for cancer, particularly Arg deprivation. The purpose of this review is to highlight recent studies that focus on Arg-dependent malignancies with Arginine (Arg)-degrading enzymes ...
Feun, Lynn G +2 more
core +3 more sources
Effect of nitric oxide donor on viability of human leukemic cells upon arginine deprivation [PDF]
Біологічні студії, 2011 Some types of tumor cells are unable to synthesize arginine from its precursors. They exhibit growth inhibition and decreased viability in vitro and in vivo under enzymatic arginine deprivation.
O. I. Chen +5 more
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BRAF inhibitor resistance enhances vulnerability to arginine deprivation in melanoma. [PDF]
Oncotarget, 2016 BRAF inhibitor (BRAFi) has been used for treatment of melanomas harboring V600E mutation. Despite a high initial response rate, resistance to BRAFi is inevitable.
Li YY +9 more
europepmc +4 more sources
Deprivation of L-Arginine Induces Oxidative Stress Mediated Apoptosis in Leishmania donovani Promastigotes: Contribution of the Polyamine Pathway. [PDF]
PLoS Neglected Tropical Diseases, 2016 The growth and survival of intracellular parasites depends on the availability of extracellular nutrients. Deprivation of nutrients viz glucose or amino acid alters redox balance in mammalian cells as well as some lower organisms.
Abhishek Mandal +11 more
doaj +2 more sources