Arginine Deprivation, Autophagy, Apoptosis (AAA) for the Treatment of Melanoma [PDF]
Current Molecular Medicine, 2010 The majority of melanoma cells do not express argininosuccinate synthetase (ASS), and hence cannot synthesize arginine from citrulline. Their growth and proliferation depend on exogenous supply of arginine.
Wangpaichitr, M +11 more
core +4 more sources
Combinatory Treatment of Canavanine and Arginine Deprivation Efficiently Targets Human Glioblastoma Cells via Pleiotropic Mechanisms [PDF]
Cells, 2020 Glioblastomas are the most frequent and aggressive form of primary brain tumors with no efficient cure. However, they often exhibit specific metabolic shifts that include deficiency in the biosynthesis of and dependence on certain exogenous amino acids ...
Olena Karatsai +4 more
doaj +2 more sources
Degradation of AMPK‐α1 sensitizes BRAF inhibitor‐resistant melanoma cells to arginine deprivation [PDF]
Molecular Oncology, 2017 Melanomas harboring BRAF mutation (V600E) are known to recur frequently following treatment with BRAF inhibitors (BRAFi) despite a high initial response rate.
Ying‐Ying Li +10 more
doaj +2 more sources
Arginine enzymatic deprivation and diet restriction for cancer treatment [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2017 Recent findings in amino acid metabolism and the differences between normal, healthy cells and neoplastic cells have revealed that targeting single amino acid metabolic enzymes in cancer therapy is a promising strategy for the development of novel ...
Wissam Zam
doaj +2 more sources
Arginine deprivation as a new treatment strategy for head and neck cancer
Oral Oncology, 2012 [[abstract]]SummaryObjectives Arginine is a nonessential amino acid which can regulate tumor growth. Argininosuccinate synthetase (ASS) is the rate-limiting enzyme for de novo arginine production.
Huang, CC;Tsai, ST;Kuo, CC;Chang, JS;Jin, YT;Chang, JY;Hsiao, JR
core +3 more sources
Deprivation of arginine by recombinant human arginase in prostate cancer cells [PDF]
Journal of Hematology & Oncology, 2012 Background Recombinant human arginase (rhArg) has been developed for arginine deprivation therapy in cancer, and is currently under clinical investigation.
Hsueh Eddy C +5 more
doaj +4 more sources
Multi-omics analysis of arginine metabolism in ovarian cancer: A prognostic signature and GTF2F2-driven stromal remodeling [PDF]
Translational OncologyBackground: Arginine metabolism shapes tumor growth, stromal activation, and antitumor immunity, yet its translational relevance in ovarian cancer (OV) remains incompletely defined.
Dongyao Zhang +7 more
doaj +2 more sources
Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes. [PDF]
Sci Rep, 2018 Tumors deficient in the urea cycle enzymes argininosuccinate synthase-1 (ASS1) and ornithine transcarbamylase (OTC) are unable to synthesize arginine and can be targeted using arginine-deprivation therapy.
Alexandrou C +15 more
europepmc +7 more sources
The effect of nitric oxide on spatial learning and memory impairment following rapid eye movement (REM) sleep deprivation in rats [PDF]
مجله علوم پزشکی فیض (پیوسته), 2023 Background and Aim: Sleep deprivation causes impairment in learning and memory. Several studies have shown the positive effect of nitric oxide on learning and memory processes.
Mahdi Bodagh, Majid Taati
doaj +2 more sources
Optimizing arginine deprivation for hard-to-treat cancers. [PDF]
Oncotarget, 2017 Khadeir R, Szyszko T, Szlosarek PW.
europepmc +4 more sources