Results 41 to 50 of about 283,349 (208)

Arginine deprivation and autophagic cell death in cancer [PDF]

Proceedings of the National Academy of Sciences, 2014
Our increasing awareness over the last decade, that reprogramming of cellular energetics is a key hallmark of tumorigenesis, has reinvigorated the search for novel tractable metabolic targets in cancer cells (1). From innovative diagnostics based on the tracer 18F-deoxyglucose in positron emission tomography (FDG-PET) to the development of next ...
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The Effect of Arginine Deprivation on the Replication of Vaccinia Virus

Journal of General Virology, 1971
Summary Arginine has been shown to be essential for the replication of vaccinia virus in HeLa cell cultures. The yield of infective virus was dependent upon the concentration of arginine in the medium, maximum yield being obtained with 0.09 mm-arginine.
L C, Archard, J D, Williamson
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Intracellular arginine-dependent translation sensor reveals the dynamics of arginine starvation response and resistance in ASS1-negative cells

Cancer & Metabolism, 2021
Background Many cancers silence the metabolic enzyme argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme for arginine biosynthesis within the urea cycle. Consequently, ASS1-negative cells are susceptible to depletion of extracellular arginine
Leonard C. Rogers, Jing Zhou, Adriana Baker, Charles R. Schutt, Prashanta K. Panda, Brian A. Van Tine   +5 more
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Cytotoxicity of tumor antigen specific human T cells is unimpaired by arginine depletion. [PDF]

, 2013
Tumor-growth is often associated with the expansion of myeloid derived suppressor cells that lead to local or systemic arginine depletion via the enzyme arginase.
Hundemer, Michael, Voss, R-H, Sergej Medenhoff, Voss Ralf-Holger, Goldschmidt, Hartmut, Knies, D, Anthony D Ho, Voss, Ralf-Holger, Knies Diana, Engelhardt, Melanie, Wabnitz, Guido, Knies, Diana, Michael Hundemer, Diana Knies, Yvonne Samstag, Munder, M, Feldmeyer, N, Samstag, Y, Theobald, Matthias, Ingrid Müller, Kropf, P, Müller, Ingrid, Markus Munder, Conradi Roland, Nadja Feldmeyer, Luckner-Minden, Claudia, Conradi, R, Roland Conradi, Mueller, I, Pascale Kropf, Matthias Theobald, Wabnitz, G, Conradi, Roland, Ho, AD, Müller Ingrid, Goldschmidt Hartmut, Hundemer Michael, Hundemer, M, Medenhoff, Sergej, Claudia Luckner-Minden, Luckner-Minden Claudia, Wabnitz Guido, Engelhardt, M, Samstag, Yvonne, Munder, Markus, Guido Wabnitz, Feldmeyer, Nadja, Theobald, M, Feldmeyer Nadja, Engelhardt Melanie, Medenhoff Sergej, Kropf Pascale, Hartmut Goldschmidt, Theobald Matthias, Ho, Anthony D, Medenhoff, S, Ralf-Holger Voss, Goldschmidt, H, Kropf, Pascale, Munder Markus, Ho Anthony D., Samstag Yvonne, Melanie Engelhardt, Luckner-Minden, C   +63 more
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Cytotoxicity of Arginine Deprivation to AML Cells is Mediated by Autophagy

, 2020
In this study, we assess the activation of autophagy in AML cells following arginine deprivation, the mechanism of its activation, and its impact on cell cytotoxicity.
Taki, Fatima
core   +1 more source

Anti-tumor activity of arginine deiminase via arginine deprivation in retinoblastoma

Oncology Reports, 2007
In spite of recent advances in the treatment of retinoblastoma, chemotherapy is still challenging in high-stage intraocular retinoblastoma or metastatic retinoblastoma. Here, we investigated whether arginine deprivation via arginine deiminase (ADI) could be a new anti-tumor therapy in retinoblastoma cells.
Jeong Hun, Kim, Jin Hyoung, Kim, Young Suk, Yu, Dong Hun, Kim, Bon-Hong, Min, Kyu-Won, Kim   +5 more
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Effects of the combined arginase and canavanine treatment on leukemic cells in vitro and in vivo [PDF]

The Ukrainian Biochemical Journal, 2016
It was previously demonstrated in in vitro experiments that canavanine (Cav), a natural toxic arginine analogue of plant origin, is a promising candidate for augmenting the antineoplastic effects of arginine starvation.
O. I. Vovk, O. I. Chen, N. I. Igumentseva, O. Yu. Senchuk, M. L. Barska, N. O. Sybirna, O. V. Stasyk   +6 more
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Arginine deprivation response is mediated by MPK2.

, 2016
Promastigotes of L. mexicana mutants lacking both copies of the MPK2 gene (Δmpk2) and those containing a single wild type copy of the gene re-inserted into their genome (addback) were subjected to 2 hours arginine deprivation as described in Fig 1.
Adele Goldman-Pinkovich (634294), Rona Strasser (125782), Caitlin Balno (2589571), Peter J. Myler (244412), Keren Bendelak (2589574), Martin Wiese (631460), Doris Rentsch (1153), Armando Jardim (125779), Dan Zilberstein (222503), Moshe Ephros (2589577), Michal Zeituni-Molad (2589568)   +10 more
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Vascular Effects of Arginine Vasopressin during Fluid Deprivation in the Rat [PDF]

Journal of Clinical Investigation, 1981
The vascular effects of arginine vasopressin (AVP) were examined in conscious Sprague-Dawley rats. In six control rats, synthetic AVP at a dose of 40 ng/kg, injected as an intravenous bolus, resulted in a rise in mean arterial blood pressure (BP) from 127 to 149 mm Hg (P < 0.005).
G A, Aisenbrey, W A, Handelman, P, Arnold, M, Manning, R W, Schrier   +4 more
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Next generation oncolytic viruses expressing PADI1 and TIMP2 exhibit anti-tumor activity against melanoma in nude and humanized mouse models

Molecular Therapy: Oncolytics, 2023
Immunotherapy of metastatic melanoma (MM) has vastly improved the longevity of only a minority of patients. To broaden the repertoire of agents against MM, we investigated the effectiveness of locally interrupting tumor blood endothelial cell ...
Lukasz Kuryk, Anne-Sophie W. Møller
doaj   +1 more source