Protein Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination. [PDF]
Acc Chem Res, 2019 Proteins are well-known to undergo a variety of post-translational modifications (PTMs). One such PTM is citrullination, an arginine modification that is catalyzed by a group of hydrolases called protein arginine deiminases (PADs). Hundreds of proteins are known to be citrullinated and hypercitrullination is associated with autoimmune diseases ...
Mondal S, Thompson PR.
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Decoding isozyme-specific substrate recognition in protein arginine deiminases by in vitro lysate-based citrullination mapping [PDF]
Nature CommunicationsProtein arginine deiminases (PADs) convert arginine to citrulline, altering protein structure. Of the five human isozymes, PAD1–4 are catalytically active with distinct tissue-specificities, yet isozyme-specific substrate recognition remains poorly ...
Sophia Laposchan +7 more
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The protein arginine deiminases: Structure, function, inhibition, and disease. [PDF]
Biopolymers, 2013 AbstractThe post‐translational modification of histones has significant effects on overall chromatin function. One such modification is citrullination, which is catalyzed by the protein arginine deiminases (PADs), a unique family of enzymes that catalyzes the hydrolysis of peptidyl‐arginine to form peptidyl‐citrulline on histones, fibrinogen, and other
Bicker KL, Thompson PR.
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Inhibiting protein arginine deiminases has antioxidant consequences. [PDF]
J Pharmacol Exp Ther, 2015 Ulcerative colitis is a dynamic, idiopathic, chronic inflammatory condition that carries a high colon cancer risk. We previously showed that Cl-amidine, a small-molecule inhibitor of the protein arginine deiminases, suppresses colitis in mice. Because colitis is defined as inflammation of the colon associated with infiltration of white blood cells that
Witalison EE +6 more
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Association of protein arginine deiminase 4 with the myosin-9 motor complex. [PDF]
J Biol ChemGenetic association data, immunohistochemistry, and functional experiments implicate protein arginine deiminase 4 (PAD4) in the pathogenesis of rheumatoid arthritis (RA). This disease is characterized by immunity against epitopes with deiminated arginine (=citrulline) originating from a multitude of intra- and extracellular proteins that are modified ...
Wang X +8 more
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Chemical biology of protein citrullination by the protein A arginine deiminases. [PDF]
Curr Opin Chem Biol, 2021 Mondal S, Thompson PR.
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Thioredoxin Modulates Protein Arginine Deiminase 4 (PAD4)-Catalyzed Citrullination [PDF]
Frontiers in Immunology, 2019 Protein citrullination is a post-translational modification catalyzed by the protein arginine deiminases (PADs). This modification plays a crucial role in the pathophysiology of numerous autoimmune disorders including RA.
Mitesh Nagar +5 more
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Protein arginine deiminase 2 (PAD2) modulates the polarization of THP-1 macrophages to the anti-inflammatory M2 phenotype [PDF]
Journal of Inflammation, 2022 Background Macrophages are effector cells of the innate immune system that undergo phenotypical changes in response to organ injury and repair. These cells are most often classified as proinflammatory M1 and anti-inflammatory M2 macrophages.
Aneta Stachowicz +5 more
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Alleviation of arthritis through prevention of neutrophil extracellular traps by an orally available inhibitor of protein arginine deiminase 4 [PDF]
Scientific Reports, 2023 Protein arginine deiminases (PAD) 4 is an enzyme that catalyzes citrullination of protein and its role in autoimmune diseases has been established through clinical genetics and gene knock out studies in mice.
Chandru Gajendran +14 more
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Oncology Reports, 2023 Chemotherapies are used for treating retinoblastoma; however, numerous patients suffer from recurrence or symptoms due to chemotherapy, which emphasizes the need for alternative therapeutic strategies. The present study demonstrated that protein arginine deiminase Ⅱ (PADI2) was highly expressed in human and mouse retinoblastoma tissues due to the ...
Sojin Kim +6 more
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