Results 31 to 40 of about 1,542 (164)

Progression on Citrullination of Proteins in Gastrointestinal Cancers

Frontiers in Oncology, 2019
The citrullination modification (Cit) of proteins has received increasing attention in recent years. This kind of protein modification was first discovered in autoimmune diseases such as rheumatoid arthritis.
Shuzheng Song, Yingyan Yu
doaj   +1 more source

Citrullination Alters the Antiviral and Immunomodulatory Activities of the Human Cathelicidin LL-37 During Rhinovirus Infection

Frontiers in Immunology, 2020
Human rhinoviruses (HRV) are the most common cause of viral respiratory tract infections. While normally mild and self-limiting in healthy adults, HRV infections are associated with bronchiolitis in infants, pneumonia in immunocompromised patients, and ...
Víctor Casanova, Filipa Henderson Sousa, Priyanka Shakamuri, Pavel Svoboda, Chloé Buch, Mathilde D'Acremont, Maria A. Christophorou, Jan Pohl, Craig Stevens, Peter G. Barlow   +9 more
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Peptidylarginine Deiminase (PAD) and Post-Translational Protein Deimination—Novel Insights into Alveolata Metabolism, Epigenetic Regulation and Host–Pathogen Interactions

Biology, 2021
The alveolates (Superphylum Alveolata) comprise a group of primarily single-celled eukaryotes that have adopted extremely diverse modes of nutrition, such as predation, photoautotrophy and parasitism.
Árni Kristmundsson, Ásthildur Erlingsdóttir, Sigrun Lange   +2 more
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Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis

Disease Models & Mechanisms, 2013
SUMMARY Multiple sclerosis (MS) is the most common CNS-demyelinating disease of humans, showing clinical and pathological heterogeneity and a general resistance to therapy.
Mario A. Moscarello, Helena Lei, Fabrizio G. Mastronardi, Shawn Winer, Hubert Tsui, Zhen Li, Cameron Ackerley, Li Zhang, Reinout Raijmakers, D. Denise Wood   +9 more
doaj   +1 more source

Activation of PAD4 in NET formation

Frontiers in Immunology, 2012
Peptidyl arginine deiminases, or PADs, convert arginine residues to the non-ribosomally encoded amino acid citrulline in a variety of protein substrates.
Amanda eRohrbach, Daniel eSlade, Paul eThompson, Kerri eMowen   +3 more
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Molecular Factors in PAD2 (PADI2) and PAD4 (PADI4) Are Associated with Interstitial Lung Disease Susceptibility in Rheumatoid Arthritis Patients

Cells, 2023
Around 50% of rheumatoid arthritis (RA) patients show some extra-articular manifestation, with the lung a usually affected organ; in addition, the presence of anti-citrullinated protein antibodies (ACPA) is a common feature, which is caused by protein ...
Karol J. Nava-Quiroz, Jorge Rojas-Serrano, Gloria Pérez-Rubio, Ivette Buendia-Roldan, Mayra Mejía, Juan Carlos Fernández-López, Pedro Rodríguez-Henríquez, Noé Ayala-Alcantar, Espiridión Ramos-Martínez, Luis Alberto López-Flores, Alma D. Del Ángel-Pablo, Ramcés Falfán-Valencia   +11 more
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Protein arginine deiminase 4 inhibition is sufficient for the amelioration of collagen-induced arthritis [PDF]

Clinical and Experimental Immunology, 2017
Summary Citrullination of joint proteins by the protein arginine deiminase (PAD) family of enzymes is recognized increasingly as a key process in the pathogenesis of rheumatoid arthritis. This present study was undertaken to explore the efficacy of a novel PAD4-selective inhibitor, GSK199, in the murine collagen-induced arthritis model ...
V C, Willis, N K, Banda, K N, Cordova, P E, Chandra, W H, Robinson, D C, Cooper, D, Lugo, G, Mehta, S, Taylor, P P, Tak, R K, Prinjha, H D, Lewis, V M, Holers   +12 more
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Extracellular vesicle signatures and protein citrullination are modified in shore crabs (Carcinus maenas) infected with Hematodinium sp

Virulence, 2023
Epizootiologists recurrently encounter symbionts and pathobionts in the haemolymph (blood equivalent) of shellfish. One such group is the dinoflagellate genus Hematodinium, which contains several species that cause debilitating disease in decapod ...
Christopher J. Coates, Igor Kraev, Andrew F. Rowley, Sigrun Lange   +3 more
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Inhibitors and Inactivators of Protein Arginine Deiminase 4:  Functional and Structural Characterization^, [PDF]

Biochemistry, 2006
Protein arginine deiminase 4 (PAD4) is a transcriptional coregulator that catalyzes the calcium-dependent conversion of specific arginine residues in proteins to citrulline. Recently, we reported the synthesis and characterization of F-amidine, a potent and bioavailable irreversible inactivator of PAD4.
Luo, Yuan, Arita, Kyouhei, Bhatia, Monica, Knuckley, Bryan, Lee, Young-Ho, Stallcup, Michael R., Sato, Mamoru, Thompson, Paul R   +7 more
openaire   +3 more sources

Post-translational Modifications in Oral Bacteria and Their Functional Impact

Frontiers in Microbiology, 2021
Oral bacteria colonize the oral cavity, surrounding complex and variable environments. Post-translational modifications (PTMs) are an efficient biochemical mechanism across all domains of life. Oral bacteria could depend on PTMs to quickly regulate their
Qizhao Ma, Qizhao Ma, Qiong Zhang, Qiong Zhang, Yang Chen, Yang Chen, Shuxing Yu, Shuxing Yu, Jun Huang, Jun Huang, Yaqi Liu, Yaqi Liu, Tao Gong, Yuqing Li, Jing Zou, Jing Zou   +15 more
doaj   +1 more source