Results 31 to 40 of about 3,416,691 (229)
Interrogation of the Active Sites of Protein Arginine Deiminases (PAD1, -2, and -4) Using Designer Probes. [PDF]
ACS Med Chem Lett, 2013 Bello AM +4 more
europepmc +2 more sources
Citrullination of Proteins as a Specific Response Mechanism in Plants
Frontiers in Plant Science, 2021 Arginine deimination, also referred to as citrullination of proteins by L-arginine deiminases, is a post-translational modification affecting histone modifications, epigenetic transcriptional regulation, and proteolysis in animals but has not been ...
Claudius Marondedze +8 more
doaj +1 more source
Histone citrullination: a new target for tumors
Molecular Cancer, 2021 As the main protein components of chromatin, histones play central roles in gene regulation as spools of winding DNA. Histones are subject to various modifications, including phosphorylation, acetylation, glycosylation, methylation, ubiquitination and ...
Dongwei Zhu, Yue Zhang, Shengjun Wang
doaj +1 more source
Development of a Selective Inhibitor of Protein Arginine Deiminase 2 [PDF]
Journal of Medicinal Chemistry, 2017 Protein arginine deiminase 2 (PAD2) plays a key role in the onset and progression of multiple sclerosis, rheumatoid arthritis, and breast cancer. To date, no PAD2-selective inhibitor has been developed. Such a compound will be critical for elucidating the biological roles of this isozyme and may ultimately be useful for treating specific diseases in ...
Aaron Muth +9 more
openaire +3 more sources
Protein arginine deiminase 4: a target for an epigenetic cancer therapy [PDF]
Cellular and Molecular Life Sciences, 2010 The recent approvals of anticancer therapeutic agents targeting the histone deacetylases and DNA methyltransferases have highlighted the important role that epigenetics plays in human diseases, and suggested that the factors controlling gene expression are novel drug targets. Protein arginine deiminase 4 (PAD4) is one such target because its effects on
Slack, Jessica L. +2 more
openaire +3 more sources
The Protein Arginine Deiminases: Inhibitors and Characteristics [PDF]
, 2015 The Protein Arginine Deiminases: Inhibitors and Characteristics MSc Pharmaceutical Sciences Convocation year of 2015 Elizabeth Joanne Curiel Tejeda Department of Pharmaceutical Sciences University of Toronto Protein arginine deiminases (PADs) are ...
Curiel Tejeda, Elizabeth Joanne
core +2 more sources
The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest. [PDF]
PLoS ONE, 2013 Protein Arginine Deiminases (PADs) catalyze the post-translational conversion of peptidyl-Arginine to peptidyl-Citrulline in a calcium-dependent, irreversible reaction. Evidence is emerging that PADs play a role in carcinogenesis. To determine the cancer-
Xiangli Cui +9 more
doaj +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism [PDF]
Biochemistry, 2007 The presumed role of an overactive protein arginine deiminase 4 (PAD4) in the pathophysiology of rheumatoid arthritis (RA) suggests that PAD4 inhibitors could be used to treat an underlying cause of RA, potentially offering a mechanism to stop further disease progression. Thus, the development of such inhibitors is of paramount importance.
Knuckley, Bryan +2 more
openaire +3 more sources