Results 51 to 60 of about 3,416,691 (229)

Identification of potential autoantigens in anti-CCP-positive and anti-CCP-negative rheumatoid arthritis using citrulline-specific protein arrays

Scientific Reports, 2021
The presence or absence of autoantibodies against citrullinated proteins (ACPAs) distinguishes two main groups of rheumatoid arthritis (RA) patients with different etiologies, prognoses, disease severities, and, presumably, disease pathogenesis.
Thomas B. G. Poulsen, Dres Damgaard, Malene M. Jørgensen, Ladislav Senolt, Jonathan M. Blackburn, Claus H. Nielsen, Allan Stensballe   +6 more
doaj   +1 more source

Study on the role of protein deiminases in the nervous system [PDF]

, 2011
"Study on the role of protein deiminases in the nervous system" Citrullination (deimination) is the conversion of protein-bound arginine to citrulline. Citrullination is catalyzed by a family of calcium-dependent enzymes, the peptidylarginine deiminases (
MILLARTE, VALENTINA
core   +1 more source

Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis

Disease Models & Mechanisms, 2013
SUMMARY Multiple sclerosis (MS) is the most common CNS-demyelinating disease of humans, showing clinical and pathological heterogeneity and a general resistance to therapy.
Mario A. Moscarello, Helena Lei, Fabrizio G. Mastronardi, Shawn Winer, Hubert Tsui, Zhen Li, Cameron Ackerley, Li Zhang, Reinout Raijmakers, D. Denise Wood   +9 more
doaj   +1 more source

Citrullination Alters the Antiviral and Immunomodulatory Activities of the Human Cathelicidin LL-37 During Rhinovirus Infection

Frontiers in Immunology, 2020
Human rhinoviruses (HRV) are the most common cause of viral respiratory tract infections. While normally mild and self-limiting in healthy adults, HRV infections are associated with bronchiolitis in infants, pneumonia in immunocompromised patients, and ...
Víctor Casanova, Filipa Henderson Sousa, Priyanka Shakamuri, Pavel Svoboda, Chloé Buch, Mathilde D'Acremont, Maria A. Christophorou, Jan Pohl, Craig Stevens, Peter G. Barlow   +9 more
doaj   +1 more source

Peptidylarginine Deiminase (PAD) and Post-Translational Protein Deimination—Novel Insights into Alveolata Metabolism, Epigenetic Regulation and Host–Pathogen Interactions

Biology, 2021
The alveolates (Superphylum Alveolata) comprise a group of primarily single-celled eukaryotes that have adopted extremely diverse modes of nutrition, such as predation, photoautotrophy and parasitism.
Árni Kristmundsson, Ásthildur Erlingsdóttir, Sigrun Lange   +2 more
doaj   +1 more source

Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae

Angewandte Chemie, EarlyView.
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray, Sohan Hazra, Ryan W. Mull, Erinn M. O'Neill, Bo Li   +4 more
wiley   +2 more sources

Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors [PDF]

Bioorganic & Medicinal Chemistry Letters, 2013
Protein arginin deaminase 4 (PAD4) is a calcium dependent enzyme which catalyses the conversion of peptidyl-arginine into peptidyl-citrulline and is implicated in several diseases such as rheumatoid arthritis (RA) and cancer. Herein we report the discovery of novel small-molecule, non peptidic PAD4 inhibitors incorporating primary/secondary guanidine ...
Bozdag M., Dreker T., Henry C., TOSCO, Paolo, VALLARO, Maura, FRUTTERO, Roberta, Scozzafava A., Carta F. *, Supuran C. T.   +8 more
openaire   +5 more sources

Activation of PAD4 in NET formation

Frontiers in Immunology, 2012
Peptidyl arginine deiminases, or PADs, convert arginine residues to the non-ribosomally encoded amino acid citrulline in a variety of protein substrates.
Amanda eRohrbach, Daniel eSlade, Paul eThompson, Kerri eMowen   +3 more
doaj   +1 more source

Molecular Factors in PAD2 (PADI2) and PAD4 (PADI4) Are Associated with Interstitial Lung Disease Susceptibility in Rheumatoid Arthritis Patients

Cells, 2023
Around 50% of rheumatoid arthritis (RA) patients show some extra-articular manifestation, with the lung a usually affected organ; in addition, the presence of anti-citrullinated protein antibodies (ACPA) is a common feature, which is caused by protein ...
Karol J. Nava-Quiroz, Jorge Rojas-Serrano, Gloria Pérez-Rubio, Ivette Buendia-Roldan, Mayra Mejía, Juan Carlos Fernández-López, Pedro Rodríguez-Henríquez, Noé Ayala-Alcantar, Espiridión Ramos-Martínez, Luis Alberto López-Flores, Alma D. Del Ángel-Pablo, Ramcés Falfán-Valencia   +11 more
doaj   +1 more source

Citrullination in health and disease: From physiological function to gene regulation

Genes and Diseases
Protein citrullination involves the deimination of arginine or methylarginine residues in peptide chains to form citrulline by peptidyl arginine deiminases.
Xiaoya Zhang, Guiqiu Xie, Lang Rao, Chaoguang Tian   +3 more
doaj   +1 more source