Results 41 to 50 of about 3,416,691 (229)

The Citrullination-Neutrophil Extracellular Trap Axis in Chronic Diseases

Journal of Innate Immunity, 2022
Citrullination of proteins is crucial for the formation of neutrophil extracellular traps (NETs) – strands of nuclear DNA expulsed in the extracellular environment along with antimicrobial proteins in order to halt the spread of pathogens. Paradoxically,
Martin Maronek, Roman Gardlik
doaj   +1 more source

Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation [PDF]

Bioorganic & Medicinal Chemistry, 2014
Protein citrullination is just one of more than 200 known PTMs. This modification, catalyzed by the protein arginine deiminases (PADs 1-4 and PAD6 in humans), converts the positively charged guanidinium group of an arginine residue into a neutral ureido-group.
Dreyton, Christina J., Anderson, Erin D., Subramanian, Venkataraman, Boger, Dale L., Thompson, Paul R   +4 more
openaire   +3 more sources

Special Issue: Peptidylarginine Deiminases and Protein Deimination in Health and Disease

, 2019
Peptidylarginine deiminases (PADs) are a group of calcium-dependent enzymes that are conserved throughout phylogeny and involved in physiological and pathophysiological processes.
Lange, S., Nicholas, A.P.
core   +4 more sources

Differential, Stage Dependent Detection of Peptidylarginine Deiminases and Protein Deimination in Lewy Body Diseases-Findings from a Pilot Study [PDF]

, 2022
Over 10 million people worldwide live with Parkinson's disease (PD) and 4% of affected people are diagnosed before the age of 50. Research on early PD-related pathways is therefore of considerable importance.
Hristova, M., Lange, S., Jaunmuktane, Z., Mercer, A.   +3 more
core   +1 more source

Padi2/3 Deficiency Alters the Epigenomic Landscape and Causes Premature Differentiation of Mouse Trophoblast Stem Cells

Cells, 2022
Histone citrullination is a relatively poorly studied epigenetic modification that involves the irreversible conversion of arginine residues into citrulline. It is conferred by a small family of enzymes known as protein arginine deiminases (PADIs).
Noura N. Ballasy, Elizabeth A. Bering, Caroline Kokorudz, Bethany N. Radford, Xiang Zhao, Wendy Dean, Myriam Hemberger   +6 more
doaj   +1 more source

Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2014
The protein arginine deiminase 4 (PAD4) is a calcium-dependent enzyme, which catalyses the irreversible conversion of peptidyl-arginines into peptidyl-citrullines and plays an important role in several diseases such as in the rheumatoid arthritis, multiple sclerosis, Alzheimer's disease, Creutzfeldt-Jacob's disease and cancer.
TRABOCCHI, ANDREA, N. Pala, I. Krimmelbein, MENCHI, GLORIA, GUARNA, ANTONIO, M. Sechi, T. Dreker, SCOZZAFAVA, ANDREA, SUPURAN, CLAUDIU TRANDAFIR, CARTA, FABRIZIO   +9 more
openaire   +5 more sources

Arginine methylation in subunits of mammalian pre-mRNA cleavage factor I [PDF]

, 2010
Mammalian cleavage factor I (CF Im) is composed of two polypeptides of 25 kDa and either a 59 or 68 kDa subunit (CF Im25, CF Im59, CF Im68). It is part of the cleavage and polyadenylation complex responsible for processing the 39 ends of messenger RNA ...
Antje Ostareck-Lederer, Neuenkirchen, N., Ostareck-Lederer, Antje, Keller, W., Dettwiler, Sabine, Sabine Dettwiler, Fischer, Utz, Martin, Georges, Rüegsegger, U., Fischer, U., Georges Martin, Ashwin Chari, Blank, Diana, Diana Blank, Neuenkirchen, Nils, Blank, D., Utz Fischer, Chari, Ashwin, Ostareck-Lederer, A., Nils Neuenkirchen, Walter Keller, Chari, A., Ursula Rüegsegger, Dettwiler, S., Martin, G., Keller, Walter, Rüegsegger, Ursula   +26 more
core   +1 more source

Novel autoantibodies in rheumatoid arthritis

Reumatismo, 2019
Rheumatoid factor and antibodies against cyclic citrullinated peptides represent a diagnostic hallmark in rheumatoid arthritis (RA). However, over the last decades many other autoantibodies have been identified.
A.F. Bonifacio, A. Alunno, G.M.C. La Paglia, E. Valentini, M.C. Leone, E. Bartoloni, Roberto Gerli   +6 more
doaj   +1 more source

Down-regulation of peptidylarginine deiminase type 1 in reconstructed human epidermis disturbs nucleophagy in the granular layer and affects barrier function

Cell Death Discovery, 2023
Deimination is a post-translational modification catalyzed by a family of enzymes named peptidylarginine deiminases (PADs). PADs transform arginine residues of protein substrates into citrulline.
Adebayo Candide Alioli, Julie Briot, Carole Pons, Hang Yang, Marie Gairin, Dominique Goudounèche, Laura Cau, Michel Simon, Marie-Claire Méchin   +8 more
doaj   +1 more source

Progression on Citrullination of Proteins in Gastrointestinal Cancers

Frontiers in Oncology, 2019
The citrullination modification (Cit) of proteins has received increasing attention in recent years. This kind of protein modification was first discovered in autoimmune diseases such as rheumatoid arthritis.
Shuzheng Song, Yingyan Yu
doaj   +1 more source