Results 61 to 70 of about 3,416,691 (229)

Protein arginine deiminase 4 inhibition is sufficient for the amelioration of collagen-induced arthritis [PDF]

Clinical and Experimental Immunology, 2017
Summary Citrullination of joint proteins by the protein arginine deiminase (PAD) family of enzymes is recognized increasingly as a key process in the pathogenesis of rheumatoid arthritis. This present study was undertaken to explore the efficacy of a novel PAD4-selective inhibitor, GSK199, in the murine collagen-induced arthritis model ...
V C, Willis, N K, Banda, K N, Cordova, P E, Chandra, W H, Robinson, D C, Cooper, D, Lugo, G, Mehta, S, Taylor, P P, Tak, R K, Prinjha, H D, Lewis, V M, Holers   +12 more
openaire   +2 more sources

Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803 [PDF]

, 2007
Schriek S, Rückert C, Staiger D, Pistorius EK, Michel K-P. Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis ...
Klaus-Peter Michel, Schriek, Sarah, Staiger Dorothee, Michel, Klaus-Peter, Rückert Christian, Schriek Sarah, Pistorius Elfriede K, Elfriede K Pistorius, Staiger, Dorothee, Sarah Schriek, Rückert, Christian ; https://orcid.org/, Michel Klaus-Peter, Pistorius, Elfriede K., Christian Rückert, Dorothee Staiger   +14 more
core   +1 more source

Extracellular vesicle signatures and protein citrullination are modified in shore crabs (Carcinus maenas) infected with Hematodinium sp

Virulence, 2023
Epizootiologists recurrently encounter symbionts and pathobionts in the haemolymph (blood equivalent) of shellfish. One such group is the dinoflagellate genus Hematodinium, which contains several species that cause debilitating disease in decapod ...
Christopher J. Coates, Igor Kraev, Andrew F. Rowley, Sigrun Lange   +3 more
doaj   +1 more source

Inhibitors and Inactivators of Protein Arginine Deiminase 4:  Functional and Structural Characterization^, [PDF]

Biochemistry, 2006
Protein arginine deiminase 4 (PAD4) is a transcriptional coregulator that catalyzes the calcium-dependent conversion of specific arginine residues in proteins to citrulline. Recently, we reported the synthesis and characterization of F-amidine, a potent and bioavailable irreversible inactivator of PAD4.
Luo, Yuan, Arita, Kyouhei, Bhatia, Monica, Knuckley, Bryan, Lee, Young-Ho, Stallcup, Michael R., Sato, Mamoru, Thompson, Paul R   +7 more
openaire   +3 more sources

Post-translational Modifications in Oral Bacteria and Their Functional Impact

Frontiers in Microbiology, 2021
Oral bacteria colonize the oral cavity, surrounding complex and variable environments. Post-translational modifications (PTMs) are an efficient biochemical mechanism across all domains of life. Oral bacteria could depend on PTMs to quickly regulate their
Qizhao Ma, Qizhao Ma, Qiong Zhang, Qiong Zhang, Yang Chen, Yang Chen, Shuxing Yu, Shuxing Yu, Jun Huang, Jun Huang, Yaqi Liu, Yaqi Liu, Tao Gong, Yuqing Li, Jing Zou, Jing Zou   +15 more
doaj   +1 more source

Mechanistic Studies of Protein Arginine Deiminase 2: Evidence for a Substrate-Assisted Mechanism [PDF]

Biochemistry, 2014
Citrullination, which is catalyzed by protein arginine deiminases (PADs 1-4 and 6), is a post-translational modification (PTM) that effectively neutralizes the positive charge of a guanidinium group by its replacement with a neutral urea. Given the sequence similarity of PAD2 across mammalian species and the genomic organization of the PAD2 gene, PAD2 ...
Dreyton, Christina J., Knuckley, Bryan, Jones, Justin E., Lewallen, Daniel M., Thompson, Paul R   +4 more
openaire   +3 more sources

One-Step ARMS-PCR for the Detection of SNPs—Using the Example of the PADI4 Gene

Methods and Protocols, 2019
In eukaryotes, cellular functions are tightly controlled by diverse post-translational modifications (PTMs) of proteins. One such PTM affecting many proteins is the deimination of arginine to citrulline.
Sabrina Ehnert, Caren Linnemann, Bianca Braun, Josephine Botsch, Karolin Leibiger, Philipp Hemmann, and Andreas K. Nussler   +6 more
doaj   +1 more source

Post-Translational Protein Deimination Signatures in Plasma and Plasma EVs of Reindeer (Rangifer tarandus)

Biology, 2021
The reindeer (caribou) Rangifer tarandus is a Cervidae in the order Artiodactyla. Reindeer are sedentary and migratory populations with circumpolar distribution in the Arctic, Northern Europe, Siberia and North America. Reindeer are an important wild and
Stefania D’Alessio, Stefanía Thorgeirsdóttir, Igor Kraev, Karl Skírnisson, Sigrun Lange   +4 more
doaj   +1 more source

In Rheumatoid Arthritis Patients, HLA-DRB1*04:01 and Rheumatoid Nodules Are Associated With ACPA to a Particular Fibrin Epitope

Frontiers in Immunology, 2021
ObjectivesRheumatoid arthritis (RA) is associated with HLA-DRB1 genes encoding the shared epitope (SE), a 5-amino acid motive. RA is usually preceded by the emergence of anti-citrullinated protein/peptide antibodies (ACPAs). Citrulline is a neutral amino
Guillaume Larid, Mikael Pancarte, Géraldine Offer, Cyril Clavel, Marielle Martin, Vincent Pradel, Isabelle Auger, Pierre Lafforgue, Jean Roudier, Jean Roudier, Guy Serre, Nathalie Balandraud, Nathalie Balandraud   +12 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source