Results 81 to 90 of about 3,416,691 (229)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

An improved synthesis of haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4) [PDF]

Tetrahedron Letters, 2008
Protein arginine deiminase 4 (PAD4) is an enzyme that hydrolyzes peptidyl arginine residues to form citrulline and ammonia. This enzyme has been implicated in several disease states, e.g. rheumatoid arthritis, and therefore represents a unique target for the development of a novel therapeutic.
Causey, Corey P., Thompson, Paul R
openaire   +3 more sources

Detection and quantification of citrullinated chemokines. [PDF]

PLoS ONE, 2011
BackgroundPosttranslational deimination or citrullination by peptidylarginine deiminases (PAD) regulates the biological function of proteins and may be involved in the development of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis.
Eva A V Moelants, Jo Van Damme, Paul Proost   +2 more
doaj   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

The effects of acute arginine supplementation on 10 mile cycling time trial performance in young adult males [PDF]

, 2012
L-arginine is one of the most metabolically versatile amino acids in the human body, most notably serving as the pre-cursor for the biosynthesis of nitric oxide (NO).
Gill, Sam
core   +2 more sources

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Environmental salinity determines the specificity and need for tat-dependent secretion of the YwbN protein in bacillus subtilis [PDF]

, 2011
Twin-arginine protein translocation (Tat) pathways are required for transport of folded proteins across bacterial, archaeal and chloroplast membranes. Recent studies indicate that Tat has evolved into a mainstream pathway for protein secretion in certain
Miethke, Marcus, Theresa Winter, Schaffer Marc, van der Ploeg, René, Jan Maarten van Dijl, Harwood, Colin R., Denham, Emma, Monteferrante, Carmine G., Ulrike Mäder, Marcus Miethke, Maeder, Ulrike, van der Ploeg René, René van der Ploeg, Mohamed A Marahiel, Denham, Emma L., Harwood Colin R., Colin R. Harwood, van Dijl, Jan Maarten, Homuth, Georg, Hecker Michael, Monteferrante Carmine G., Carmine G Monteferrante, Georg Homuth, Mäder Ulrike, Mäder, Ulrike, van Dijl Jan Maarten, Winter Theresa, Emma L. Denham, Homuth Georg, Miethke Marcus, Schaffer, Marc, Michael Hecker, Marahiel Mohamed A., Hecker, Michael, Dijl, Jan Maarten van, Winter, Theresa, Haike Antelmann, Marahiel, Mohamed A., Antelmann, Haike, Antelmann Haike, Carmine G. Monteferrante, Emma L Denham, Denham Emma L., Colin R Harwood, Marc Schaffer, Mohamed A. Marahiel   +45 more
core   +2 more sources

A rigorous method for multigenic families' functional annotation: the peptidyl arginine deiminase (PADs) proteins family example

BMC Genomics, 2005
Background large scale and reliable proteins' functional annotation is a major challenge in modern biology. Phylogenetic analyses have been shown to be important for such tasks.
Blanc M, Danchin EGJ, Gouret P, Balandraud N, Zinn D, Roudier J, Pontarotti P   +6 more
doaj   +1 more source

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, EarlyView.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source

Oral microbiome and homeostatic regulation of periodontal health: From dysbiosis to precision intervention

VIEW, EarlyView.
Periodontal homeostasis is maintained by coordinated interactions between the oral microbiome and host. Dysbiosis disrupts this ecological balance and contributes to periodontal disease, whereas multi‐omics, artificial intelligence, and microbiome‐based interventions provide emerging opportunities for precision diagnosis, ecological restoration, and ...
Xu Liu, Lei Meng, Wenzhu Song, Peiyu Wang, Bin Liu, Shihui Liu, Qi He, Bing Sun, Wanheng Li, Zhiwei Guan, Rui Dong, Qiang Feng   +11 more
wiley   +1 more source