Results 101 to 110 of about 3,416,691 (229)

Periodontitis and Rheumatoid Arthritis—Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
Periodontitis and rheumatoid arthritis are linked via the two‐hit model whereby early periodontal inflammation can lead to autoantibody production capable of interacting with inflamed synovial tissues. Subsequent systemic inflammation can exacerbate the periodontal inflammatory response and bacterial dysbiosis leading to further autoantibody production
Mark Bartold, Chia Wei Cheah, Rathna Devi Vaithilingam   +2 more
wiley   +1 more source

Structural insights into the enzymatic breakdown of azomycin-derived antibiotics by 2-nitroimdazole hydrolase (NnhA)

Communications Biology
The antibiotic 2-nitroimidazole (2NI) or azomycin, used for treating drug-resistant tuberculosis and imaging tumor hypoxia, requires activation by bacterial nitroreductases for its antibiotic and cytotoxic effect. Mycobacterium sp.
F. Hafna Ahmed, Jian-Wei Liu, Santana Royan, Andrew C. Warden, Lygie Esquirol, Gunjan Pandey, Janet Newman, Colin Scott, Thomas S. Peat   +8 more
doaj   +1 more source

Cooperative effects of urea and L-arginine on protein refolding

, 2009
The use of low concentrations of urea, guanidinium chloride or arginine has been reported in the literature to increase protein refolding and yield of active proteins by suppressing aggregate formation. However, no studies have yet examined whether these
Wang, Yinjue, Ding, Hong, Su, ZG, Li, Xiunan, Ma, Guanghui, Su, Zhiguo, Liu, Yongdong, Chen, Jing   +7 more
core   +1 more source

Peptidylarginine Deiminase 3 (PAD3) Is Upregulated by Prolactin Stimulation of CID-9 Cells and Expressed in the Lactating Mouse Mammary Gland.

PLoS ONE, 2016
Peptidylarginine deiminases (PADs) post-translationally convert arginine into neutral citrulline residues. Our past work shows that PADs are expressed in the canine and murine mammary glands; however, the mechanisms regulating PAD expression and the ...
Guangyuan Li, Isaac N Hayward, Brittany R Jenkins, Heather M Rothfuss, Coleman H Young, Marja T Nevalainen, Aaron Muth, Paul R Thompson, Amy M Navratil, Brian D Cherrington   +9 more
doaj   +1 more source

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Identification and characterization of two temperature-induced surface-associated proteins of Streptococcus suis with high homologies to members of the arginine deiminase system of Streptococcus pyogenes [PDF]

, 2002
The present study was performed to identify stress-induced putative virulence proteins of Streptococcus suis. For this, protein expression patterns of streptococci grown at 32, 37, and 42°C were compared by one- and two-dimensional gel electrophoresis ...
Gruening, P., Smith, H.E., Winterhoff, N., Valentin-Weigand, P., Goethe, R., Kalisz, H., Rohde, M.   +6 more
core   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

Binding of the heterogeneous ribonucleoprotein K (hnRNP K) to the Epstein-Barr virus nuclear antigen 2 (EBNA2) enhances viral LMP2A expression. [PDF]

, 2012
The Epstein-Barr Virus (EBV) -encoded EBNA2 protein, which is essential for the in vitro transformation of B-lymphocytes, interferes with cellular processes by binding to proteins via conserved sequence motifs.
Stephanie Barth, Neuenkirchen, N., Alfredo Mamiani (146650), Grässer, Friedrich A., Ostareck-Lederer, Antje, Leonhardt, Heinrich, Nils Neuenkirchen (146673), Fischer, Utz, Bodo Moritz, Friedrich A Grässer, Wen Deng, Masouris, Ilias, Barth, Stephanie, Fischer, U., Hennard, C., Christian Cassel, Neuenkirchen, Nils, Utz Fischer (146680), Utz Fischer, Ute Stober-Grässer (146645), Elfriede Noessner (146689), Noessner, Elfriede, Henrik Gross (146622), Bodo Moritz (146655), Dirk Ostareck, Mamiani, Alfredo, Stephanie Barth (145387), Nößner, E., Alfredo Mamiani, Ostareck, Dirk, Christine Hennard (146627), Christian Cassel (146638), Moritz, Bodo, Antje Ostareck-Lederer, Elfriede Noessner, Deng, Wen, Gross, H., Christine Hennard, Ostareck, Dirk H., Antje Ostareck-Lederer (146668), Dirk Ostareck (146662), Heinrich Leonhardt (18589), Henrik Gross, Stober-Grässer, U., Masouris, I., Friedrich A. Grässer (145412), Kremmer, E., Wen Deng (123626), Grässer, F.A., Kremmer, Elisabeth, Cassel, C., Deng, W., Ilias Masouris (146632), Ilias Masouris, Ostareck-Lederer, A., Mamiani, A., Heinrich Leonhardt, Gross, Henrik, Moritz, B., Nils Neuenkirchen, Barth, S., Ostareck, D., Cassel, Christian, Stober-Grässer, Ute, Elisabeth Kremmer (17351), Ute Stober-Grässer, Elisabeth Kremmer, Leonhardt, H., Hennard, Christine   +68 more
core   +2 more sources

Inhibition of protein arginine deiminase 4 prevents inflammation-mediated heart failure in arthritis [PDF]

, 2023
Lukas Andreas Heger, Nicolas Schommer, Shoichi Fukui, Stijn Van Bruggen, Casey E. Sheehy, Long Chu, Sridharan Rajagopal, Dhanalakshmi Sivanandhan, Bruce M. Ewenstein, Denisa D. Wagner   +9 more
openalex   +1 more source

Metabolic reprogramming of the immune response in periodontitis

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon, Melissa Grant, Iain Chapple, Joao Paulo Steffens   +3 more
wiley   +1 more source