Results 21 to 30 of about 3,416,691 (229)

Citrullination in tumor immunity and therapy [PDF]

The Journal of Clinical Investigation
Peptidyl arginine deiminases (PADs) catalyze the conversion of arginine residues into peptidyl citrulline, a posttranslational modification known as protein citrullination (or arginine deimination).
Michael R. Pitter, Weiping Zou
doaj   +2 more sources

A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy [PDF]

Journal of Extracellular Vesicles, 2015
Introduction: Protein deimination, defined as the post-translational conversion of protein-bound arginine to citrulline, is carried out by a family of 5 calcium-dependent enzymes, the peptidylarginine deiminases (PADs) and has been linked to various ...
Sharad Kholia, Samireh Jorfi, Paul R. Thompson, Corey P. Causey, Anthony P. Nicholas, Jameel M. Inal, Sigrun Lange   +6 more
doaj   +3 more sources

Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca2+ dependent allosteric binding site [PDF]

Nature Communications
Peptidylarginine deiminases (PAD1-4) are calcium dependent enzymes responsible for protein citrullination, a post-translational modification converting arginine residues to citrulline.
Leslie A. Dakin, Li Xing, Justin Hall, Weidong Ding, Felix F. Vajdos, Jeffrey W. Pelker, Simeon Ramsey, Paul Balbo, Parag V. Sahasrabudhe, Mary Ellen Banker, Won Young Choi, Stephen W. Wright, Jeanne S. Chang, John M. Curto, Jennifer E. Davoren, Susan E. Drozda, Kimberly F. Fennell, Kentaro Futatsugi, Steve Kortum, Katherine L. Lee, Shenping Liu, Frank Lovering, Jennifer A. Nicki, John I. Trujillo, Fabien Vincent, Mark E. Schnute   +25 more
doaj   +2 more sources

Picking the PADlock: Chemical Probes to Study the Protein Arginine Deiminases

FASEB Journal, 2015
The Protein Arginine Deiminases (PADs) are a small family of human enzymes that catalyze the post‐translational hydrolysis of arginine residues to generate citrulline. These enzymes are important regulators of gene transcription and their activity is upregulated in multiple inflammatory diseases, including rheumatoid arthritis, ulcerative colitis, and ...
Paul R Thompson
exaly   +2 more sources

Citrullination-associated transcriptional states identify a non-canonical invasive program in malignant epithelial cells and correlate with SPP1-CD44 immune microenvironment niches in thyroid cancer [PDF]

Translational Oncology
Background: Citrullination, a post-translational modification catalyzed by protein arginine deiminases (PADIs), has been implicated in malignant progression across multiple cancer types.
Zhisheng Tian, Peiling Zhu, Xiujuan Zhao, Fan Yang   +3 more
doaj   +2 more sources

Protein-Arginine Deiminase Type-4 [PDF]

, 2020
National Cancer Institute
openalex   +2 more sources

Protein-Arginine Deiminase Type-2 [PDF]

, 2020
National Cancer Institute
openalex   +2 more sources

Unveiling nuclear localization signals in human arginine deiminase proteins. [PDF]

Protein Sci
Neira JL, Abian O, Velazquez-Campoy A, Rizzuti B.   +3 more
europepmc   +2 more sources

The Development of Benzimidazole-Based Clickable Probes for the Efficient Labeling of Cellular Protein Arginine Deiminases (PADs). [PDF]

ACS Chem Biol, 2018
Nemmara VV, Subramanian V, Muth A, Mondal S, Salinger AJ, Maurais AJ, Tilvawala R, Weerapana E, Thompson PR.   +8 more
europepmc   +2 more sources

Expression of chemical modification enzymes PADs and PRMTs targeting protein arginine residues in human hepatocellular carcinoma cell lines [PDF]

Jichu yixue yu linchuang, 2023
Objective To explore the expression of protein arginine deiminases (PADs) and protein arginine methyltransferases (PRMTs) in hepatocellular carcinoma, and to analyze whether the level of protein citrullination catalyzed by PADs is related to the ...
ZOU Jin, HE Xianglei, ZHANG Xin, CHEN Riping, ZHANG Yu, HU Shuaiyue, YING Shibo
doaj   +1 more source