Results 11 to 20 of about 1,542 (164)

Histone citrullination: a new target for tumors

Molecular Cancer, 2021
As the main protein components of chromatin, histones play central roles in gene regulation as spools of winding DNA. Histones are subject to various modifications, including phosphorylation, acetylation, glycosylation, methylation, ubiquitination and ...
Dongwei Zhu, Yue Zhang, Shengjun Wang
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Protein arginine deiminase 2 (PAD2) modulates the polarization of THP-1 macrophages to the anti-inflammatory M2 phenotype

Journal of Inflammation, 2022
Background Macrophages are effector cells of the innate immune system that undergo phenotypical changes in response to organ injury and repair. These cells are most often classified as proinflammatory M1 and anti-inflammatory M2 macrophages.
Aneta Stachowicz, Rakhi Pandey, Niveda Sundararaman, Vidya Venkatraman, Jennifer E. Van Eyk, Justyna Fert-Bober   +5 more
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Photochemical Control of Protein Arginine Deiminase (PAD) Activity [PDF]

ACS Chemical Biology, 2018
Protein arginine deiminases (PADs) play an important role in the pathogenesis of various diseases, including rheumatoid arthritis, multiple sclerosis, lupus, ulcerative colitis, and breast cancer. Therefore, the development of PAD inhibitors has drawn significant research interest in recent years.
Santanu Mondal, Sangram S. Parelkar, Mitesh Nagar, Paul R. Thompson   +3 more
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Development of a Selective Inhibitor of Protein Arginine Deiminase 2 [PDF]

Journal of Medicinal Chemistry, 2017
Protein arginine deiminase 2 (PAD2) plays a key role in the onset and progression of multiple sclerosis, rheumatoid arthritis, and breast cancer. To date, no PAD2-selective inhibitor has been developed. Such a compound will be critical for elucidating the biological roles of this isozyme and may ultimately be useful for treating specific diseases in ...
Aaron Muth, Venkataraman Subramanian, Edward Beaumont, Mitesh Nagar, Philip Kerry, Paul McEwan, Hema Srinath, Kathleen Clancy, Sangram Parelkar, Paul R. Thompson   +9 more
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Protein arginine deiminase 4: a target for an epigenetic cancer therapy [PDF]

Cellular and Molecular Life Sciences, 2010
The recent approvals of anticancer therapeutic agents targeting the histone deacetylases and DNA methyltransferases have highlighted the important role that epigenetics plays in human diseases, and suggested that the factors controlling gene expression are novel drug targets. Protein arginine deiminase 4 (PAD4) is one such target because its effects on
Slack, Jessica L., Causey, Corey P., Thompson, Paul R   +2 more
openaire   +3 more sources

The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest. [PDF]

PLoS ONE, 2013
Protein Arginine Deiminases (PADs) catalyze the post-translational conversion of peptidyl-Arginine to peptidyl-Citrulline in a calcium-dependent, irreversible reaction. Evidence is emerging that PADs play a role in carcinogenesis. To determine the cancer-
Xiangli Cui, Erin E Witalison, Alena P Chumanevich, Alexander A Chumanevich, Deepak Poudyal, Venkataraman Subramanian, Aaron J Schetter, Curtis C Harris, Paul R Thompson, Lorne J Hofseth   +9 more
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The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Alleviation of arthritis through prevention of neutrophil extracellular traps by an orally available inhibitor of protein arginine deiminase 4

Scientific Reports, 2023
Protein arginine deiminases (PAD) 4 is an enzyme that catalyzes citrullination of protein and its role in autoimmune diseases has been established through clinical genetics and gene knock out studies in mice.
Chandru Gajendran, Shoichi Fukui, Naveen M. Sadhu, Mohammed Zainuddin, Sridharan Rajagopal, Ramachandraiah Gosu, Sarah Gutch, Saeko Fukui, Casey E. Sheehy, Long Chu, Santosh Vishwakarma, D. A. Jeyaraj, Gurulingappa Hallur, Denisa D. Wagner, Dhanalakshmi Sivanandhan   +14 more
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Protein Arginine Deiminase 4:  Evidence for a Reverse Protonation Mechanism [PDF]

Biochemistry, 2007
The presumed role of an overactive protein arginine deiminase 4 (PAD4) in the pathophysiology of rheumatoid arthritis (RA) suggests that PAD4 inhibitors could be used to treat an underlying cause of RA, potentially offering a mechanism to stop further disease progression. Thus, the development of such inhibitors is of paramount importance.
Knuckley, Bryan, Bhatia, Monica, Thompson, Paul R   +2 more
openaire   +3 more sources

The Citrullination-Neutrophil Extracellular Trap Axis in Chronic Diseases

Journal of Innate Immunity, 2022
Citrullination of proteins is crucial for the formation of neutrophil extracellular traps (NETs) – strands of nuclear DNA expulsed in the extracellular environment along with antimicrobial proteins in order to halt the spread of pathogens. Paradoxically,
Martin Maronek, Roman Gardlik
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