ASS1 Overexpression: A Hallmark of Sonic Hedgehog Hepatocellular Adenomas; Recommendations for Clinical Practice [PDF]
Hepatology Communications, 2020 Until recently, 10% of hepatocellular adenomas (HCAs) remained unclassified (UHCA). Among the UHCAs, the sonic hedgehog HCA (shHCA) was defined by focal deletions that fuse the promoter of Inhibin beta E chain with GLI1.
Margaux Sala +35 more
doaj +16 more sources
Metabolic vulnerabilities of rhabdomyosarcoma: insights into the role of ASS1 [PDF]
, 2022 [eng] Rhabdomyosarcoma (RMS) is the most prevalent soft tissue sarcoma (STS) in children and adolescents. The Alveolar subtype (ARMS) is driven by PAX3-FOXO1, a fusion protein originated from a chromosomal translocation. PAX3-FOXO1 is considered a key player in ARMS initiation and progression, due to its enhanced transcriptional activity, that leads to
Monaco, Paola
core +7 more sources
The role of ASS1 in mouse embryonic stem cell differentiation into mesendoderm lineages
Stem Cell Research & TherapyBackground Argininosuccinate synthase (ASS1) is a pivotal enzyme involved in the urea cycle, playing a crucial role in aspartate catabolism, arginine and nitric oxide biosynthesis.
Guodong Zhao +7 more
doaj +4 more sources
Ass1 and its role in renal fibrosis [PDF]
, 2020 BACKGROUND: The incidence of chronic kidney disease (CKD) is rising and is the 12th most common cause of death worldwide. Currently, the only available treatments are renal replacement therapy and transplantation, both of which are significantly costly for the NHS.
Finnie, Sarah Louise
openaire +4 more sources
Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1α Degradation at the ASS1 promoter for ASS1 Derepression [PDF]
Scientific Reports, 2017 AbstractArgininosuccinate synthetase 1 (ASS1) is the key enzyme that controls biosynthesis of arginine (Arg). ASS1 is silenced in many human malignancies therefore, these tumors require extracellular Arg for growth. The Arg-degrading recombinant protein, pegylated arginine deiminase (ADI-PEG20), has been in clinical trials for targeting Arg auxotrophic
Tsai, Wen-Bin +7 more
openaire +4 more sources
Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma. [PDF]
PLoS ONE, 2016 To investigate the underlying causes of chemoresistance in malignant pleural mesothelioma, we have studied mesothelioma cell lines as 3D spheroids, which acquire increased chemoresistance compared to 2D monolayers. We asked whether the gene expression of
Dario Barbone +8 more
doaj +5 more sources
Mutations and polymorphisms in the human argininosuccinate synthetase (ASS1) gene [PDF]
Human Mutation, 2008 Citrullinemia type I is an autosomal recessive disorder that is caused by a deficiency of the urea cycle enzyme argininosuccinate synthetase (ASS1). Deficiency of ASS1 shows various clinical manifestations encompassing severely affected patients with fatal neonatal hyperammonemia as well as asymptomatic individuals with only a biochemical phenotype ...
Engel, K, Höhne, W, Häberle, J
openaire +3 more sources
Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect [PDF]
Molecular & Cellular Oncology, 2017 Argininosuccinate Synthetase 1 deficiency induces dependence on extracellular arginine for continued cellular growth and survival. Arginine starvation inhibits the Warburg effect and diverts glucose into serine biosynthesis, while simultaneously ...
Jeff C. Kremer, Brian A. Van Tine
doaj +3 more sources
Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM [PDF]
BMC Cancer, 2018 Background Tumour cells have a high demand for arginine. However, a subset of glioblastomas has a defect in the arginine biosynthetic pathway due to epigenetic silencing of the rate limiting enzyme argininosuccinate synthetase (ASS1).
Lina Mörén +6 more
doaj +5 more sources
Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers [PDF]
Cell Reports, 2017 Targeting defects in metabolism is an underutilized strategy for the treatment of cancer. Arginine auxotrophy resulting from the silencing of argininosuccinate synthetase 1 (ASS1) is a common metabolic alteration reported in a broad range of aggressive ...
Jeff Charles Kremer +18 more
doaj +2 more sources