Results 41 to 50 of about 5,002 (185)

Loss of Argininosuccinate Synthetase-1 (ASS1) Occurs in Esophageal Adenocarcinoma and Represents a Promising Biomarker for Therapy With Pegargiminase [PDF]

Cancers
Christiane J Bruns, Alexander Quaas, Su Ir Lyu   +2 more
exaly   +2 more sources

The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer

Cancer & Metabolism, 2021
Background Arginine (Arg) is essential for cancer cell growth and also for the activation of T cells. Thus, therapies aiming to reduce Arg utilization by cancer may prove detrimental for the immune response.
Alexandra Giatromanolaki, Adrian L. Harris, Michael I. Koukourakis   +2 more
doaj   +1 more source

Reduced expression of argininosuccinate synthetase 1 has a negative prognostic impact in patients with pancreatic ductal adenocarcinoma.

PLoS ONE, 2017
Argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme for arginine biosynthesis, is expressed in many types of human malignancies. Recent studies showed that ASS1 may have tumor suppressor function and that ASS1 deficiency is associated with ...
Qingqing Liu, John Stewart, Hua Wang, Asif Rashid, Jun Zhao, Matthew H Katz, Jeffrey E Lee, Jason B Fleming, Anirban Maitra, Robert A Wolff, Gauri R Varadhachary, Sunil Krishnan, Huamin Wang   +12 more
doaj   +1 more source

Hypomorphic citrullinaemia due to mutatedASS1with episodic ataxia [PDF]

BMJ Case Reports, 2018
Children with citrullinaemia commonly present in the neonatal period with life-threatening hyperammonaemia and progressive encephalopathy. Less often, ‘hypomorphic’ or mild late-onset childhood or adult-onset forms may be seen with intermittent neurological symptoms or acute crisis in pregnancy.
Arushi Gahlot, Saini, Savita, Attri, N, Sankhyan, Pratibha, Singhi   +3 more
openaire   +2 more sources

Cloning and functional analysis of the promoter of the sesquiterpene synthase gene ASS1 in Aquilaria sinensis

Biologia Plantarum, 2021
Agarwood, the resin part of Aquilaria spp., is valued in medicine, perfumes, and incense. The most important components of agarwood are sesquiterpenes, which are produced only when a healthy tree is wounded.
Y.H. XU, F.F. LV, P.W. SUN, M.H. TIAN, J.H. WEI   +4 more
doaj   +1 more source

Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors

, 2020
Argininosuccinate synthase (ASS1) downregulation in different tumors has been shown to support cell proliferation and yet, in several common cancer subsets ASS1 expression associates with poor patient prognosis.
Oren, R., Shen, T.W., Lerner, S., Goldman, O., Lee, J.S., Brandis, A., Itkin, M., Keshet, R., Katzir, R., Mehlman, T., Talsania, K., Galai, S., Landesman, H., Ruppin, E., Erez, A., Malitsky, S., Tishler, H.W., Zhao, Y.M., Peled, N., Adler, L., Lim, L.Q.J., Kuznetsov, Y., Porgador, A., Rabinovich, S., Iraqi, M., Stettner, N., Koehler, S.E.; id_orcid, Kuperman, Y., Ariav, Y., Ulitsky, I.   +29 more
core   +1 more source

BAP1 loss is associated with higher ASS1 expression in epithelioid mesothelioma: implications for therapeutic stratification. [PDF]

, 2023
The nuclear deubiquitylase BRCA1 associated protein 1 (BAP1) is frequently inactivated in malignant pleural mesothelioma (MPM) and germline BAP1 mutation predisposes to cancers including MPM.
Goate, Z, Jackson, Richard, Grosman, R, Lian, L-Y, Kenyani, Jenna, Lu-Yun Lian, Butt, Z, Querques, Francesca, Jenna Kenyani, Judy M. Coulson, Jackson, R, Peter W. Szlosarek, Tripari, Martina, Querques, F, Francesca Querques, Zohra Butt, Shaw, Liam, Sarah E. Barnett, Rudi Grosman, Grosman, Rudi, Luisa C. Silva, Marciniak, Stefan J, Silva, Luisa C, Tripari, M, Marciniak, SJ, Sacco, Joseph J, Kenyani, J, Szlosarek, PW, Zoe Goate, Martina Tripari, Richard Jackson, Barnett, Sarah E, Shaw, L, Rassl, Doris M, Szlosarek, Peter W, Liam Shaw, Barnett, SE, Goate, Zoe, Rassl, DM, Coulson, JM, Coulson, Judy M, Stefan J. Marciniak, Lian, Lu-Yun, Butt, Zohra, Joseph J. Sacco, Sacco, JJ, Doris M. Rassl, Silva, LC   +47 more
core   +1 more source

Snail enhances arginine synthesis by inhibiting ubiquitination-mediated degradation of ASS1

The EMBO Reports, 2021
Snail is a dedicated transcriptional repressor and acts as a master inducer of EMT and metastasis, yet the underlying signaling cascades triggered by Snail still remain elusive. Here, we report that Snail promotes colorectal cancer (CRC) migration by preventing non-coding RNA LOC113230-mediated degradation of argininosuccinate synthase 1 (ASS1 ...
Hao Jia, Yuquan Yang, Mengying Li, Yimin Chu, Huan Song, Jie Zhang, Dan Zhang, Qun Zhang, Ying Xu, Jiamin Wang, Hong Xu, Xiuqun Zou, Haixia Peng, Zhaoyuan Hou   +13 more
openaire   +2 more sources

ASS1 protein is upregulated in 3D in mesothelioma cells but not in normal mesothelial cells.

, 2016
(A) ASS1 antibodies (BD clone 25, Sigma clone 2B10, and Millipore clone 2C10) were tested against ASS1-positive MSTO pIRES-ASS1 (as a positive control) and ASS1-negative MSTO pIRES-EV (as a negative control).
Dario Barbone (111176), Shu-Dong Zhang (231229), Carlo Follo (348842), Raphael Bueno (111214), Puthen V. Jithesh (356701), Dean A. Fennell (111225), William G. Richards (231936), Loes Van Dam (3178485), V. Courtney Broaddus (111230)   +8 more
core   +1 more source

ASS1 Promotes Atherosclerotic Inflammation Through the NLRP3/IL-33/ST2 Axis in Ox-LDL–Induced Foam Cells

Frontiers in Bioscience-Landmark
Background: Atherosclerosis is a chronic inflammatory disease characterized by lipid-driven immune dysregulation. Argininosuccinate synthase 1 (ASS1) has been implicated in macrophage inflammation, yet its precise mechanistic role in ...
Shaoyu Wu, Feihuang Han, Zheng Qiao, Sheng Yuan, Xiaohui Bian, Bin Zhang, Kefei Dou, Dunliang Ma   +7 more
doaj   +1 more source