The CRISPR‒Cas9 system for genome editing of the ASS1 gene in human cells to predict its effect on HSV-1 replication [PDF]
Journal of Current Biomedical ReportsHerpes simplex virus type 1 (HSV-1) is a highly contagious pathogen that establishes lifelong latent infections. The replication of HSV-1 is potentially influenced by the arginine succinate synthase (ASS1) gene, a key regulator of cellular metabolism ...
Nastaran Khodadad +5 more
doaj +2 more sources
Dietary Arginine Sets the Pace of MHC Class I Translation: A Nutrient Lever on Tumour Immunogenicity. [PDF]
MedComm (2020)MedComm, Volume 7, Issue 11, November 2026.
Asim M.
europepmc +2 more sources
Hepatology, EarlyView., 2022 Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode +16 more
wiley +1 more source
FoxO transcription factors coordinate the urea cycle and gluconeogenesis by controlling <i>Ass1</i>. [PDF]
iScienceAmino acid catabolism during fasting requires coordinated nitrogen disposal and glucose production, but the transcriptional logic linking the urea cycle to gluconeogenesis remains unclear. Forkhead box O (FoxO) transcription factors regulate fasting metabolism, and here we identify FoxOs as direct hepatic regulators of argininosuccinate synthase 1 ...
Karkoutly S +10 more
europepmc +3 more sources
Dual Urea Cycle Dysfunction Caused by Coexisting Argininosuccinic Aciduria and Citrin Deficiency: Clinical, Biochemical, and Molecular Insights From an Exceptional Case. [PDF]
JIMD RepABSTRACT Dual inherited defects affecting urea cycle function are exceptionally rare. We report the first case, to our knowledge, of the coexistence of argininosuccinic aciduria (ASA) and citrin deficiency (CD). A girl born to consanguineous Tunisian parents presented at 6 months of age with recurrent seizures, vomiting, developmental delay, and severe
Zribi M +6 more
europepmc +2 more sources
Identification of Novel Mutations in Chinese Infants With Citrullinemia
Frontiers in Genetics, 2022 Citrullinemia is a rare autosomal recessive disorder characterized by elevated concentrations of citrulline in the blood resulting from malfunction of the urea cycle. It is categorized into two types, types I and II, which are caused by argininosuccinate
Zhi Cheng +9 more
doaj +1 more source
CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis [PDF]
Molecular Cell, 2017 In addition to responding to environmental entrainment with diurnal variation, metabolism is also tightly controlled by cell-autonomous circadian clock. Extensive studies have revealed key roles of transcription in circadian control. Post-transcriptional regulation for the rhythmic gating of metabolic enzymes remains elusive.
Ran, Lin +8 more
openaire +2 more sources
Argininosuccinate synthase 1, arginine deprivation therapy and cancer management
Frontiers in Pharmacology, 2022 Metabolic reprogramming is an emerging hallmark of tumor cells. In order to survive in the nutrient-deprived environment, tumor cells rewire their metabolic phenotype to provide sufficient energy and build biomass to sustain their transformed state and ...
Naihui Sun, Xing Zhao
doaj +1 more source
Cell Reports, 2016 Argininosuccinate synthase 1 (ASS1) is the rate-limiting enzyme for arginine biosynthesis. ASS1 expression is lost in a range of tumor types, including 50% of malignant pleural mesotheliomas.
Matthew Locke +10 more
doaj +1 more source
Extracellular vesicles from human liver stem cells restore argininosuccinate synthase deficiency
Stem Cell Research & Therapy, 2017 Background Argininosuccinate synthase (ASS)1 is a urea cycle enzyme that catalyzes the conversion of citrulline and aspartate to argininosuccinate. Mutations in the ASS1 gene cause citrullinemia type I, a rare autosomal recessive disorder characterized ...
Maria Beatriz Herrera Sanchez +13 more
doaj +1 more source