Results 51 to 60 of about 5,002 (185)
Frontiers in Cellular Neuroscience, 2015 ß-amyloid (Aß1-42) is produced by proteolytic cleavage of the transmembrane type-1 protein, amyloid precursor protein. Under pathological conditions, Aß1-42 self-aggregates into oligomers, which cause synaptic dysfunction and neuronal loss, and are ...
Maria Laura eGiuffrida +18 more
doaj +1 more source
Cancer Medicine, 2021 Introduction We evaluated the arginine‐depleting enzyme pegargiminase (ADI‐PEG20; ADI) with pemetrexed (Pem) and cisplatin (Cis) (ADIPemCis) in ASS1‐deficient non‐squamous non‐small cell lung cancer (NSCLC) via a phase 1 dose‐expansion trial with ...
Peter W. Szlosarek +17 more
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Early prediction of phenotypic severity in Citrullinemia Type 1
Annals of Clinical and Translational Neurology, 2019 Objective Citrullinemia type 1 (CTLN1) is an inherited metabolic disease affecting the brain which is detectable by newborn screening. The clinical spectrum is highly variable including individuals with lethal hyperammonemic encephalopathy in the newborn
Matthias Zielonka +9 more
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ASS1 knockdown by siRNA increases the chemosensitivity of spheroids.
, 2016 (A) Immunoblot analysis of M28, SARC, VAMT and ASS1-deficient MSTO spheroids, transfected with siRNA targeting ASS1 or control sequences show that ASS1 was efficiently knocked down in all the cells where it was expressed.
Dario Barbone (111176) +8 more
core +1 more source
Nature CommunicationsTo date, treating ulcerative colitis (UC) remains a significant challenge due to its complex etiology. In this study, metabolomics and proteomics analysis for multi-center cohorts reveal that both serum arginine levels and the rate-limiting enzyme ...
Shijia Liu +26 more
doaj +1 more source
Hepatic Adenomas in Men: Diagnostic Considerations and Management in the Modern Era
Journal of Surgical Oncology, EarlyView.ABSTRACT Hepatic adenomas (HAs) are rare benign liver tumors traditionally associated with young women, yet contemporary epidemiologic trends reveal increasing recognition among men. Historically, universal resection in males has been recommended because of a nearly tenfold increased risk of malignant transformation as reported by Farges et al.
Teresa Belledent +9 more
wiley +1 more source
A NEW PROOF OF THE PERSISTENCE PROPERTY FOR IDEALS IN DEDEKIND RINGS AND PR¨UFER DOMAINS [PDF]
Journal of Algebraic Systems, 2014 In this paper, by using elementary tools of commutative algebra,we prove the persistence property for two especial classes of rings. In fact, thispaper has two main sections.
Mehrdad Nasernejad
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PROTEOMICS, EarlyView.ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca +7 more
wiley +1 more source
Cancer Science, EarlyView.A rapid and efficient CRISPR‐mediated gene editing platform for TIL engineering identified FAM84B as a novel potential target to enhance antitumor activity and pioneered the use of CBE to generate FAM84B loss‐of‐function TIL with enhanced antitumor activity.
Fenge Li +13 more
wiley +1 more source