Results 71 to 80 of about 5,002 (185)

PGAM1 regulation of ASS1 contributes to the progression of breast cancer through the cAMP/AMPK/CEBPB pathway

Molecular Oncology, 2022
Phosphoglycerate mutase 1 (PGAM1) is a crucial glycolytic enzyme, and its expression status has been confirmed to be associated with tumor progression and metastasis. However, the precise role and other biological functions of PGAM1 remain unclear. Here,
Min Liu, Runmei Li, Min Wang, Ting Liu, Qiuru Zhou, Dong Zhang, Jian Wang, Meng Shen, Xiubao Ren, Qian Sun   +9 more
doaj   +1 more source

Finding My Path: Listening, Learning, and Leading in Rare Disease: The 2025 Hower Award

Annals of the Child Neurology Society, EarlyView.
Andrea Gropman
wiley   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation

, 2016
Many human tumors require extracellular arginine (Arg) for growth because the key enzyme for de novo biosynthesis of Arg, argininosuccinate synthetase 1 (ASS1), is silenced.
Chang, Jeffrey T, Tsai, Wen-Bin, Chen, Helen H W, Estecio, Marcos, Wangpaichitr, Medhi, Savaraj, Naramol, Feun, Lynn G, Long, Yan, Kuo, Macus Tien   +8 more
core   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Correlation of ASS1 Expression and Clinicopathologic Parameters in Untreated Group and Treated Groups.

, 2017
Correlation of ASS1 Expression and Clinicopathologic Parameters in Untreated Group and Treated Groups.
Asif Rashid (678658), Anirban Maitra (125932), Sunil Krishnan (2282686), Jeffrey E. Lee (106810), John Stewart (58152), Jun Zhao (59250), Qingqing Liu (15909), Hua Wang (13530), Gauri R. Varadhachary (3163977), Matthew H. Katz (635821), Robert A. Wolff (678664), Huamin Wang (143068), Jason B. Fleming (217666)   +12 more
core   +1 more source

Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors

Translational Oncology, 2020
Many human malignancies require extracellular arginine (Arg) for survival because the key enzyme for de novo Arg biosynthesis, argininosuccinate synthetase 1 (ASS1), is silenced. Recombinant arginine deiminase (ADI-PEG20), which digests extracellular Arg,
Macus Tien Kuo, Yan Long, Wen-Bin Tsai, Ying-Ying Li, Helen H.W. Chen, Lynn G. Feun, Niramol Savaraj   +6 more
doaj   +1 more source

Generation of an ASS1 heterozygous knockout human embryonic stem cell line, WAe001-A-13, using CRISPR/Cas9

Stem Cell Research, 2018
The ASS1 gene encodes argininosuccinate synthetase-1, a cytosolic enzyme with a critical role in the urea cycle. Mutations are found in all ASS1 exons and cause the autosomal recessive disorder citrullinemia. Using CRISPR/Cas9-editing, we established the
Fang Yuan, Dongsheng Guo, Yanli Liu, Yingying Xu, Ge Gao, Yuhang Wu, Fan Yang, Xinrong Ke, Keyu Lai, Hongcheng Wei, Yin-Xiong Li   +10 more
doaj   +1 more source

Glutamine Metabolism in Health and Diseases

MedComm, Volume 7, Issue 10, October 2026.
Glutamine metabolism acts as a metabolic hub connecting cellular stress adaptation, immune regulation, and disease development. Through regulating energy production, biosynthesis, redox balance, and nitrogen metabolism, glutamine supports cellular homeostasis under physiological and pathological conditions.
Yi Ding, Fan Tong, Jing Zeng, Chun‐Ping Cui   +3 more
wiley   +1 more source

ASS1 gene expression is upregulated in 3D spheroids and mesothelioma patients.

, 2016
qRT-PCR results showing the Log2-transformed fold change in gene expression for ASS1, ANXA4 and MVP between M28, REN and VAMT spheroids and monolayers. Results were normalized to the gene expression levels of monolayers (gray line).
Dario Barbone (111176), Shu-Dong Zhang (231229), Carlo Follo (348842), Raphael Bueno (111214), Puthen V. Jithesh (356701), Dean A. Fennell (111225), William G. Richards (231936), Loes Van Dam (3178485), V. Courtney Broaddus (111230)   +8 more
core   +1 more source