Results 81 to 90 of about 5,002 (185)
, 2021 Additional file 1: Figure S1. ASS1 and ASL expression affects survival in ccRCC patients. A. Survival curve based on ASS1 expression in patients from the TCGA. (High n=176, low n=352). B.
Graham Lobel (11791748) +7 more
core +1 more source
Ischemic Stroke and Traumatic Brain Injury: Epidemiology, Molecular Pathways, and Emerging Therapies
MedComm, Volume 7, Issue 10, October 2026.Schematic overview of secondary brain injury after ischemic stroke and traumatic brain injury. Both conditions trigger endothelial cell dysfunction, pericyte contraction, and upregulated AQP4 expression in astrocytic end‐feet, leading to blood–brain barrier disruption.
Mengzhao Feng +7 more
wiley +1 more source
Fumarate and Its Esters: Physiology, Pathology, Molecular Mechanisms, Diseases, and Therapy
MedComm, Volume 7, Issue 10, October 2026.Fumarate is an endogenous immunometabolite that regulates metabolism, redox homeostasis, and inflammation. Although fumaric acid esters (FAEs) share several molecular targets with fumarate, their distinct physicochemical properties confer unique biological activities and therapeutic applications.
Peng Zhu +6 more
wiley +1 more source
The Pathological Roles of Cationic Amino Acid Transporters (CATs) in Cancer
Cancer Science, Volume 117, Issue 10, Page 2636-2643, October 2026.CAT family transporters (SLC7A1–SLC7A4) coordinate arginine allocation within the tumor microenvironment, thereby regulating cancer metabolism, mTORC1 signaling, immune responses, and metastatic progression. Emerging evidence supports context‐dependent roles for SLC7A1–SLC7A3, whereas the physiological and pathological functions of SLC7A4 remain poorly
Thant Thant Myo Oo, Yasuhiro Saito
wiley +1 more source
BMC Medical Genetics, 2019 Background Citrullinemia type I (CTLN1) is a rare autosomal recessive disorder of the urea cycle caused by a deficiency in the argininosuccinate synthetase (ASS1) enzyme due to mutations in the ASS1 gene.
Yiming Lin +8 more
doaj +1 more source
Clinics and Research in Hepatology and Gastroenterology, 2019 Three liver nodules were fortuitously discovered in a 30-year-old obese woman during a gynecological workup and resected. Two nodules (6 and 1.5 cm) with histological characteristics of inflammatory hepatocellular adenoma (HCA) were C reactive protein positive with normal expression of glutamine synthetase.
Nora, Frulio +4 more
openaire +3 more sources
, 2013 Figure-S5 PDF file 92K, Figure-S5 ASS1 reexpression attenuates cell migration and invasiveness of myxofibrosarcoma cells. (A) Wound healing assay (left panel) reveals that the capability of wound closure is significantly impaired in both stable ASS1 ...
Fu-Min Fang (502561) +13 more
core +1 more source
Abstract 5569: The impact of ADI-PEG20 on PDL1 expression in ASS1 deficient uveal melanoma
, 2017 Uveal melanoma (UM), involving the iris, choroid and ciliary body, is the commonest intraocular tumor in adults. Half of patients develop metastasis with a high mortality despite currently available systemic therapies including immune checkpoint blockade.
Peter W. Szlosarek +5 more
core +1 more source
Example ASS1 of how the total score is calculated (see main text).
, 2013 Example ASS1 of how the total score is calculated (see main text).
Jing Guo (102972) +5 more
core +1 more source
ASS1 Promotes Colorectal Cancer Immune Evasion Through CPT1A-Mediated S100A10 Succinylation
Frontiers in Bioscience-LandmarkBackground: Colorectal cancer (CRC) progression is frequently driven by metabolic reprogramming and immune evasion. A crucial metabolic enzyme, argininosuccinate synthetase 1 (ASS1), is dysregulated in a number of malignancies; however,
Liping Sun, Daidi Fu, Heng Zhang
doaj +1 more source