Results 101 to 110 of about 5,002 (185)

Supplementary Data from Acid-Induced Downregulation of ASS1 Contributes to the Maintenance of Intracellular pH in Cancer

, 2019
Supplementary Figures 1-5 further support our findings regarding the contribution to the maintenance of intracellular pH for ASS1 downregulated cancer ...
Sandesh C.S. Nagamani (14937437), Igor Ulitsky (28697), Alon Silberman (3206481), Sivan Galai (14937431), Joo Sang Lee (8318571), Erez Persi (229020), Raya Eilam (14889113), Omer Goldman (14937410), Lital Adler (4385842), Alona Sarver (14937425), Shiran Rabinovich (14937419), Julia Frug (14937428), Yehudit Zaltsman-Amir (14937434), Eytan Ruppin (23002), Ben Pode-Shakked (6526064), Adi Jacob (14937416), Rom Keshet (14937422), Keren Bahar Halpern (11547701), Yair Anikster (349974), Noa Stettner (14883786), Ayelet Erez (14883768), Odeya Boukobza Assayag (14937413)   +21 more
core   +1 more source

[Therapeutic efficacy of ASS1 combined with LOLA in the treatment of hyperammonemia in mice]. [PDF]

Zhong Nan Da Xue Xue Bao Yi Xue Ban
Argininosuccinate synthase 1 (ASS1) is a key rate-limiting enzyme in the urea cycle and is highly conserved at the protein level. Its catalytic activity directly determines the efficiency of ammonia clearance. Hyperammonemia is a clinical syndrome caused by abnormally elevated blood ammonia levels and is characterized mainly by central nervous system ...
Luo T, Ming Z, Zou Z, Luo Z.
europepmc   +3 more sources

ASS1 protein is expressed in mesothelioma samples and upregulated when compared to normal tissues.

, 2016
(A) ASS1 stain intensity was measured in 88 mesothelioma samples by immunohistochemistry (each tumor in replicates of 3) in a semi-quantitative fashion as outlined in the Methods section.
Dario Barbone (111176), Shu-Dong Zhang (231229), Carlo Follo (348842), Raphael Bueno (111214), Puthen V. Jithesh (356701), Dean A. Fennell (111225), William G. Richards (231936), Loes Van Dam (3178485), V. Courtney Broaddus (111230)   +8 more
core   +1 more source

Additional file 2: of Citrullinemia type I is associated with a novel splicing variant, c.773 + 4A > C, in ASS1: a case report and literature review

, 2019
Table S2. Primers used for PCR and Sanger sequencing of exon 11 of ASS1.
Lin Zhu (192179), Tianwen Zheng (6850001), Shuang Zhou (339964), Yiming Lin (174403), Hongzhi Gao (4506061), Qingliu Fu (4740864), Mengyi Jiang (4349539), Bin Lu (65603), Weihua Lin (4523680)   +8 more
core   +1 more source

Abstract 4445: Pegylated arginine deiminase induces mitochondrial apoptosis and synergizes with cisplatin in ASS1-negative malignant pleural mesothelioma

, 2010
We have explored the role of pegylated arginine deiminase (ADI-PEG20), an arginine catabolizing enzyme, in argininosuccinate synthetase 1 (ASS1)-negative malignant pleural mesothelioma (MPM). MPM is a chemorefractory disease, increasing worldwide, with a
Claude Chelala, Alex Chacko, Puthen V. Jithesh, Peter W. Szlosarek, Dean A. Fennell, Nicholas R. Lemoine, Barbara Delage   +6 more
core   +1 more source

Invasive lobular carcinoma: integrated multi-omics analysis reveals silencing of Argininosuccinate synthase and upregulation of nucleotide biosynthesis in tamoxifen resistance

Cell Death and Disease
Invasive Lobular Carcinoma (ILC), a distinct subtype of breast cancer, is hallmarked by E-Cadherin loss, slow proliferation, and strong hormone receptor positivity.
Annapurna Gupta, Fouad Choueiry, Jesse Reardon, Nikhil Pramod, Anagh Kulkarni, Eswar Shankar, Steven T. Sizemore, Daniel G. Stover, Jiangjiang Zhu, Bhuvaneswari Ramaswamy, Sarmila Majumder   +10 more
doaj   +1 more source

ASS1 Gene [PDF]

, 2020
openaire   +1 more source

Figure-S4 from ASS1 as a Novel Tumor Suppressor Gene in Myxofibrosarcomas: Aberrant Loss via Epigenetic DNA Methylation Confers Aggressive Phenotypes, Negative Prognostic Impact, and Therapeutic Relevance

, 2013
Figure-S4 PDF file 86K, Figure-S4 ASS1 reexpression induces cell cycle arrest at the G1 phase in myxofibrosarcoma cells with consistent downregulation of cyclin E expression.
Fu-Min Fang (502561), Shau-Hsuan Li (311693), Wen-Ren Wu (14987633), Yu-Hui Wang (2975586), Hsiao-Chin Hung (14991924), Yow-Ling Shiue (3459221), Chien-Feng Li (355973), Jen-Wei Tsai (14991921), Jun-Wen Wang (9416989), Hsuan-Ying Huang (2202985), Shih-Chen Yu (14973406), Jui Lan (3632881), Chung-His Hsing (14991927), Li-Tzong Chen (388257)   +13 more
core   +1 more source

ASS1 Gene Deficiency [PDF]

, 2020
openaire   +1 more source

Case Report: From coma to genetic insights: identification of a novel pathogenic variant in Chinese neonatal CTLN1

Frontiers in Pediatrics
Citrullinemia type I (CTLN1) is an autosomal recessive disorder caused by variants in the arginine succinate synthase gene (ASS1). These variants result in arginine succinate synthase deficiency, leading to a disruption of the urea cycle and ...
Lijing Deng, Yaping Liu, Kai Chen, Jianwu Qiu, Lu Chang, Junxia Xia, Yanrong Wang   +6 more
doaj   +1 more source