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Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
On the Difference between Assumption-Based Argumentation and Abstract Argumentation [PDF]
, 2015 Acknowledgements The first author has been supported by the National Research Fund, Luxembourg (LAAMI project) and by the Engineering and Physical Sciences Research Council (EPSRC, UK), grant ref. EP/J012084/1 (SAsSy project).
Alcântara, João +3 more
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Report on argumentation and teacher education in Europe [PDF]
, 2010 This document will ultimately form part of a comprehensive package of materials for teacher education and professional development in argumentation.
Blake, Allan +3 more
core
Argumentación: Hacia Un Esquema Conceptual
Logos: Revista de Lingüística, Literatura y Filosofía, 2012 RESUMEN Estudio de la argumentación desde la conceptualización, las estructuras argumentativas, la tipología argumental, las funciones, la organización secuencial, las condiciones y estilos de la argumentación, el emisor y el receptor en la ...
Jesús Portillo Fernández
doaj
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Disciplinary and Interdisciplinary Science Education Research, 2019 Argumentation has emerged as a key area of research and development in science education in recent years. Simply defined, argumentation is about the justification of knowledge claims with evidence and reasons.
Sibel Erduran +4 more
doaj +1 more source
Informal Logic, 1995 The relationship between emotions and argumentation is not always clear. I attempt to clarify this issue by referring to three basic questions: (1) Do emotions constitute a certain kind of argumentation?; (2) Do emotions constitute rational argumentation?
Aaron Ben-Zeev
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source