Results 71 to 80 of about 79,506 (261)
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
ESQUEMA DE ARGUMENTO DE TOULMIN COMO INSTRUMENTO DE ENSINO: EXPLORANDO POSSIBILIDADES
Ensaio Pesquisa em Educação em Ciências, 2014 Argumentation is a recent focus in science education research, sothere are many areas requiring further research. Questions that need to be addressed include the following: “Is the quality of argumentation determined by the presence of particular ...
Luciana Passos Sá +2 more
doaj
Raumforschung und Raumordnung, 2012 There are numerous ways to define ‘landscape’ or ‘cultural landscape’—a fact that can be irritating. We do not propose any “new” notion of landscape. By contrast we examine how ‘landscape’ and ‘cultural landscape’ acquire meaning in political discourses.
Markus Leibenath, Antje Otto
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
An Approach to Argumentation Schemes that Appeal to Expert Opinion [PDF]
, 2013 Argumentation is a form of reasoning that deeply resembles the human mechanism for commonsense reasoning. An argumentation scheme is a representational tool for modeling common patterns of reasoning; in particular, it displays the form of an argument by ...
Budan, Maximiliano Celmo David +2 more
core
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
On the Knowledge of God and the Metaphysics of Aquinas [PDF]
, 2018 Thomas Aquinas argues in his seminal work, the Summa Theologiae, that one can come to know the existence of God through rational argumentation alone. As a theologian writing a work of theology, he makes his demonstrations concerning God’s existence from ...
Green, Tom
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Геофизический журнал, 2015 There is a problem of the mechanism of Neogene magmatism appearance in Transcarpathia within tectonic evolution of the Carpathian-Pannonian region. In consideration of general submeridional compression the new kinematic and dynamic scheme of Neogene ...
V. Shevchuk, A. Vasilenko
doaj +1 more source