Results 81 to 90 of about 3,024 (290)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Abstract Argumentation Scheme Frameworks [PDF]

, 2008
This paper presents an approach to modelling and reasoning about arguments that exploits and combines two of the most popular mechanisms used within computational modelling of argumentation: argumentation schemes and abstract argumentation frameworks. Our proposal combines the desirable properties of each by representing the components of argumentation
Katie Atkinson, Trevor J. M. Bench-Capon
openaire   +1 more source

Building agents that plan and argue in a social context.

, 2006
In order for one agent to meet its goals, it will often need to influence another to act on its behalf, particularly in a society in which agents have heterogenous sets of abilities.
Karunatillake, N., Norman, Timothy J., Kalofonos, D., Reed, C, Reed, Chris; id_orcid, Kalofonos, D, Nishan Karunatillake, Kalofonos, Dionysis, Norman, TJ, Karunatillake, Nishan, Karunatillake, N, Jennings, N. R., Reed, C., Nicholas R. Jennings, Simon Wells, Jennings, Nicholas R., Wells, Simon, Wells, S, Wells, S., Timothy J. Norman, Chris Reed, Jennings, NR, Norman, Timothy, Dionysis Kalofonos   +23 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Tectonophysical conditions of late stages of evolution in the middle part of Transcarpathian deep fault

Геофизический журнал, 2015
There is a problem of the mechanism of Neogene magmatism appearance in Transcarpathia within  tectonic evolution of the Carpathian-Pannonian region. In consideration of general submeridional compression the new kinematic and dynamic scheme of Neogene ...
V. Shevchuk, A. Vasilenko
doaj   +1 more source

A proposal for the evaluation of multimodal argumentation : Assessing reasonableness and effectiveness in environmental campaign posters [PDF]

We argue that the evaluation of multimodal arguments needs to take into account the semiotic resources used to communicate them as well as the context in which they are produced and interpreted.
Tseronis, Assimakis, Üzelgün, M. A., Younis, Ramy, Üzelgün, Mehmet Ali,, Younis, R., Tseronis, A., Üzelgün, Mehmet Ali, Younis, Ramy,, Tseronis, Assimakis,   +8 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Why Fallacies Appear to be Better Arguments Than They Are

Informal Logic, 2010
This paper offers a solution to the problem of understanding how a fallacious argument can be deceptive by “seeming to be valid”, or (better) appearing to be a better argument of its kind than it really is.
Douglas Walton
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source