Results 71 to 80 of about 3,024 (290)

A functional perspective on argumentation schemes [PDF]

Argument & Computation, 2016
In multi-agent systems (MAS), abstract argumentation and argumentation schemes are increasingly important. To be useful for MAS, argumentation schemes require a computational approach so that agents can use the components of a scheme to construct and present arguments and counterarguments.
openaire   +4 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Argumentation scheme and shared online diagramming in case- based collaborative learning Argumentation schemes and case-based collaborative learning

, 2020
: Argumentation schemes describe patterns of reasoning in discourse. We report an investigation into whether the argumentation scheme known as 'inference to the best explanation' (IBE) captures the argumentation found in collaborative case ...
J Dowell, M Asgari-Targhi, M Tscholl
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Diskursive Konstituierung von Kulturlandschaft am Beispiel politischer Windenergiediskurse in Deutschland

Raumforschung und Raumordnung, 2012
There are numerous ways to define ‘landscape’ or ‘cultural landscape’—a fact that can be irritating. We do not propose any “new” notion of landscape. By contrast we examine how ‘landscape’ and ‘cultural landscape’ acquire meaning in political discourses.
Markus Leibenath, Antje Otto
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

ESQUEMA DE ARGUMENTO DE TOULMIN COMO INSTRUMENTO DE ENSINO: EXPLORANDO POSSIBILIDADES

Ensaio Pesquisa em Educação em Ciências, 2014
Argumentation is a recent focus in science education research, sothere are many areas requiring further research. Questions that need to be addressed include the following: “Is the quality of argumentation determined by the presence of particular ...
Luciana Passos Sá, Ana Claudia Kasseboehmer, Salete Linhares Queiroz   +2 more
doaj  

Bayesian Argumentation-Scheme Networks: A Probabilistic Model of Argument Validity Facilitated by Argumentation Schemes [PDF]

Proceedings of the 8th Workshop on Argument Mining, 2021
Takahiro Kondo, Koki Washio, Katsuhiko Hayashi 0001, Yusuke Miyao   +3 more
openaire   +1 more source

Argumentation schemes as a way of arguments studies

Philosophy Journal, 2021
The paper investigates argument (argumentation) schemes that are used in the theory of argumentation for analyzing everyday reasoning. Such schemes should be understood as structures representing the most general types of argument. Today they are studied not only from theoretical perspectives but also in relation to their application in education and ...
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source