Results 71 to 80 of about 54,707 (265)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Requirements engineering: a review and research agenda [PDF]
, 1994 This paper reviews the area of requirements engineering. It outlines the key concerns to which attention should be devoted by both practitioners, who wish to "reengineer" their development processes, and academics, seeking intellectual challenges. It
Finkelstein, A.
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Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
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Linguistik Online, 2018 This study aims to explore how Swiss print media convey climate change to laypeople. Due to the subjects' complexity and scope, its mediation can result in difficulties.
Nadine Kammermann
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A principled approach to the implementation of argumentation models [PDF]
, 2014 Argumentation theory combines philosophical concepts and computational models to deliver a practical approach to reasoning that handles uncertain information and possibly conflicting viewpoints.
Nilsson, Henrik, van Gijzel, Bas
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Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
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Theoria, 2014 I offer an account of a fortiori arguments in the context of a Toulmin-style theory of argumentation schemes. A fortiori arguments contain a comparison of the strength of two or more arguments involving scalar inferences.
Hubert Marraud
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Argumentation-based design rationale - the sharpest tools in the box [PDF]
, 1997 In this paper the three main argumentation-based design rationale methodologies - IBIS, QOC and DRL – will be discussed with illustrations of particular points drawn from a working example.
Stumpf, S.
core
Argumentative Scheme for Abduction
Discourse, 2023 Introduction. The paper scrutinizes abduction through the lens of the argumentation theory. Abduction is treated as an argument with a special argumentative scheme. Argumentation schemes are seen as stereotypical patterns of common types of arguments used in everyday discourse.
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Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
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