Results 71 to 80 of about 2,211 (278)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Linguistik Online, 2018 This study aims to explore how Swiss print media convey climate change to laypeople. Due to the subjects' complexity and scope, its mediation can result in difficulties.
Nadine Kammermann
doaj +1 more source
Argument Mining Using Argumentation Scheme Structures
, 2016 Argumentation schemes are patterns of human reasoning which have been detailed extensively in philosophy and psychology. In this paper we demonstrate that the structure of such schemes can provide rich information to the task of automatically identify complex argumentative structures in natural language text.
John Lawrence, Chris Reed 0001
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Theoria, 2014 I offer an account of a fortiori arguments in the context of a Toulmin-style theory of argumentation schemes. A fortiori arguments contain a comparison of the strength of two or more arguments involving scalar inferences.
Hubert Marraud
doaj +1 more source
Bayesian Argumentation-Scheme Networks: A Probabilistic Model of Argument Validity Facilitated by Argumentation Schemes [PDF]
Proceedings of the 8th Workshop on Argument Mining, 2021 Takahiro Kondo +3 more
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Argumentation schemes as a way of arguments studies
Philosophy Journal, 2021 The paper investigates argument (argumentation) schemes that are used in the theory of argumentation for analyzing everyday reasoning. Such schemes should be understood as structures representing the most general types of argument. Today they are studied not only from theoretical perspectives but also in relation to their application in education and ...
openaire +2 more sources
Statutory Interpretation as Argumentation [PDF]
, 2011 This chapter proposes a dialectical approach to legal interpretation, consisting of three dimensions: (1) a formalization of the canons of interpretation in terms of argumentation schemes; (2) a dialectical classification of interpretive schemes; and (3)
Giovanni Sartor +5 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source