Results 71 to 80 of about 6,787,949 (343)

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Teisinis samprotavimas: argumentacinis metodologinis požiūris

Teisė, 2009
Teisinis argumentavimas, samprotavimas, teisės aiškinimas – susiję, sutampantys, o kartais tapatinami teise grįsto sprendimo priėmimo proceso aspektai. Lietuviškoje teisės doktrinoje plačiau analizuojama teisės aiškinimo, interpretavimo problematika, o ...
Eglė Mackuvienė
doaj   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

A World of Difference: The Rich State of Argumentation Theory

Informal Logic, 1995
This paper surveys the contributions to the study of argumentation in the two decades since the work of Toulmin and Perelman. Developments include Radical Argumentativism (Anscombre and Ducot), Communication and Rhetoric (American Speech Communication ...
Frans H. van Eemeren
doaj   +1 more source

The incompleteness problem for a virtue-based theory of argumentation [PDF]

, 2013
The incompleteness problem for virtue ethics is inherited by a virtue-based theory of argumentation as developed by Daniel Cohen (2007). A complete normative theory of argumentation should be able to provide reasons for why argumentative virtues such as ...
MacPherson, Brian
core   +1 more source

CD9‐association with PIP2 areas is regulated by a CD9 salt bridge

FEBS Open Bio, EarlyView.
The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi, Sara C. Konopka, Thorsten Lang   +2 more
wiley   +1 more source

Michael A. Gilbert: Not arguing logically is not illogical: Other ways of communicating arguments

Argumentation et Analyse du Discours
Michael A. Gilbert has contributed significantly to the field of contemporary Argumentation Theory. Most notable are his multi-modal theory of argumentation and coalescent argumentation, models of argument that he developed to address how interlocutors ...
Michael A. Gilbert, Linda Carozza
doaj   +1 more source

Selected topics in e^+e^- collisions [PDF]

, 2006
Content : 1) The leading twist pion wave function, 2) "Improved" QCD sum rules with non-local condensates, 3) Pion and kaon form factors and charmonium decays: theory vs experiment, 4) \gamma^{*}\gamma\pi^{o} - form factor, 5) The new non-local axial ...
Bakulev, Bakulev, Balitsky, Ball, Bebek, Benayoun, Braun, Brodsky, Chernyak, Chernyak, Chernyak, Chernyak, Chernyak, Chernyak, Del Debbio, Diehl, Gockeler, Gosdzinsky, Gronberg, Khodjamirian, Lepage, Melikhov, Mikhailov, Nakazawa, Pedlar, Shifman, Victor L. Chernyak   +26 more
core   +2 more sources

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Daniel Bachurski, Michael Hallek
wiley   +1 more source