Results 81 to 90 of about 246,980 (329)
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Teoria de l'argumentació i pràctica de l'argumentació [PDF]
, 2006 The problematic relationship between theory and practice is the core of this paper, with special regard to rhetoric as theory (as an explicative system supported by a rhetorician, that is a procedure of proof) and rhetoric as practice (as an operative ...
Cattani, Adelino
core +1 more source
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
THE VIRTUOUS CITIZEN: REGIMES AND AUDIENCES
Studia Universitatis Babeș-Bolyai. Philosophia, 2017 The purpose of the present paper is to sketch the possibility of an audience theory specific to virtue argumentation taking as a starting point what Aristotle has to say about political audiences in the context of specific political constitutions and ...
Iovan DREHE DREHE
doaj +1 more source
Amyotrophic Lateral Sclerosis Prevalence Projection in 2040: A Less Rare Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To project ALS prevalence across multiple countries through 2040, accounting for both population aging and increased survival. Methods Data from the Piemonte and Valle d'Aosta ALS register (PARALS) was used to estimate the trends in incidence and prevalence from 2005 to 2019. Survival trends over this period were also assessed.
Rosario Vasta +18 more
wiley +1 more source
In Defense of the Objective Epistemic Approach to Argumentation
Informal Logic, 2008 In this paper we defend a particular version of the epistemic approach to argumentation. We advance some general considerations in favor of the approach and then examine the ways in which different versions of it play out with respect to the theory of ...
John Biro, Harvey Siegel
doaj +1 more source
The Pragma-Dialectical Reconstruction of Teleological-Evaluative Argumentation in Complex Structures of Legal Justification [PDF]
, 2007 I give a pragma-dialectical reconstruction of the role of teleological-evaluative argumentation referring to goals and values in the justification of judicial decisions.
Feteris, Eveline
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela +13 more
wiley +1 more source
Justification and Argumentation
Studies in Logic, Grammar and Rhetoric, 2014 In her paper “Argumentation theory and the conception of epistemic justification”, Lilian Bermejo-Luque presents a critique of deductivism in argumentation theory, as well as her own concept of epistemic justification inspired by the views of Stephen ...
Szymanek Krzysztof
doaj +1 more source