Comparative Analysis of Aristolochic Acids in Aristolochia Medicinal Herbs and Evaluation of Their Toxicities [PDF]
Toxins, 2022 Aristolochic acids (AAs) are a group of nitrophenanthrene carboxylic acids present in many medicinal herbs of the Aristolochia genus that may cause irreversible hepatotoxicity, nephrotoxicity, genotoxicity and carcinogenicity.
Shu-Han Zhang +8 more
doaj +4 more sources
Rapid Identification and Simultaneous Quantification of Aristolochic Acids by HPLC-DAD and Confirmations by MS in Aristolochia chilensis Using a Limited Biomass [PDF]
Journal of Analytical Methods in Chemistry, 2018 Six aristolochic acids were identified in the Chilean species Aristolochia chilensis using high-performance liquid chromatography coupled to a diode array detector (HPLC-DAD) and subsequent confirmation with mass spectrometry (MS).
Michael Araya +2 more
doaj +4 more sources
Aristolochic Acids: Newly Identified Exposure Pathways of this Class of Environmental and Food-Borne Contaminants and its Potential Link to Chronic Kidney Diseases [PDF]
Toxics, 2019 Aristolochic acids (AAs) are nitrophenanthrene carboxylic acids naturally produced by Aristolochia plants. These plants were widely used to prepare herbal remedies until AAs were observed to be highly nephrotoxic and carcinogenic to humans.
Chi-Kong Chan +3 more
doaj +4 more sources
Rapid Analysis of Aristolochic Acids and Aristolactams in Houttuyniae Herba by LC–MS/MS [PDF]
Molecules, 2022 Houttuyniae herba, the Saururaceae plant Houttuynia cordata Thunb., has multiple therapeutic effects, including clearing heat, eliminating toxins, reducing swelling, discharging pus, and relieving stagnation.
Yingxue Wu +4 more
doaj +2 more sources
Aristolochic acid: What urologists should know
Archivio Italiano di Urologia e Andrologia, 2022 To the Editor, Aristolochic acid is one of major causes for upper tract urothelial carcinoma, especially in younger population. While it is mentioned as a cause in guidelines, little is actually known about the toxin by urologists. We are aiming in our letter to provide some direct and clear information to ourselves that would help us to know more ...
M. Thangavelu +6 more
openalex +4 more sources
Aristolochic acids exposure was not the main cause of liver tumorigenesis in adulthood [PDF]
Acta Pharmaceutica Sinica B, 2022 Aristolochic acids (AAs) have long been considered as a potent carcinogen due to its nephrotoxicity. Aristolochic acid I (AAI) reacts with DNA to form covalent aristolactam (AL)–DNA adducts, leading to subsequent A to T transversion mutation, commonly ...
Shuzhen Chen +21 more
doaj +2 more sources
Unveiling correlations between aristolochic acids and liver cancer: spatiotemporal heterogeneity phenomenon [PDF]
Chinese MedicineAristolochic acids are a class of naturally occurring compounds in Aristolochiaceae that have similar structural skeletons and chemical properties.
Chengxian Li +12 more
doaj +2 more sources
Worldwide research trends on aristolochic acids (1957-2017): Suggestions for researchers. [PDF]
PLoS ONE, 2019 Aristolochic acids and their derivatives are components of many traditional medicines that have been used for thousands of years, particularly in Asian countries.
Qiang Zhou +7 more
doaj +2 more sources
In situ metabolomics in nephrotoxicity of aristolochic acids based on air flow-assisted desorption electrospray ionization mass spectrometry imaging [PDF]
Acta Pharmaceutica Sinica B, 2020 Understanding of the nephrotoxicity induced by drug candidates is vital to drug discovery and development. Herein, an in situ metabolomics method based on air flow-assisted desorption electrospray ionization mass spectrometry imaging (AFADESI-MSI) was ...
Zhonghua Wang +7 more
doaj +2 more sources
Sequestration of aristolochic acids from meridic diets by larvae of Battus polydamas archidamas (Papilionidae: Troidini) [PDF]
European Journal of Entomology, 2011 Larvae of the butterfly, Battus polydamas archidamas (Papilionidae: Troidini) feed exclusively on aristolochic acid (AAs)-containing Aristolochia species (Aristolochiaceae).
Carlos F. PINTO +2 more
doaj +2 more sources