Worldwide research trends on aristolochic acids (1957-2017): Suggestions for researchers. [PDF]
PLoS ONE, 2019 Aristolochic acids and their derivatives are components of many traditional medicines that have been used for thousands of years, particularly in Asian countries.
Qiang Zhou +7 more
doaj +3 more sources
Interactions of Human Organic Anion Transporters With Aristolochic Acids
Journal of Pharmacological Sciences, 2010 Aristolochic acids (AAs), contained in Chinese herbal preparations, have been considered to induce nephropathy. In order to elucidate the molecular mechanisms of AA-induced nephrotoxicity, we have elucidated the interaction of human organic anion ...
Ellappan Babu +8 more
doaj +2 more sources
Environmental Health Insights, 2011 Background Aristolochic Acids (AAs) are major components of plants in Aristolochia and have been found to be nephrotoxic, carcinogenic and mutagenic. Herein reported are the isolation, identification and quantity determination methods of Aristolochic ...
Abdelgadir A. Abdelgadir +2 more
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Comparative Analysis of Aristolochic Acids in Aristolochia Medicinal Herbs and Evaluation of Their Toxicities [PDF]
Toxins, 2022 Aristolochic acids (AAs) are a group of nitrophenanthrene carboxylic acids present in many medicinal herbs of the Aristolochia genus that may cause irreversible hepatotoxicity, nephrotoxicity, genotoxicity and carcinogenicity.
Shu-Han Zhang +8 more
doaj +2 more sources
Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids [PDF]
Journal of Applied Toxicology, Volume 46, Issue 8, Page 2599-2622, August 2026.ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza +2 more
wiley +2 more sources
Unveiling correlations between aristolochic acids and liver cancer: spatiotemporal heterogeneity phenomenon [PDF]
Chinese MedicineAristolochic acids are a class of naturally occurring compounds in Aristolochiaceae that have similar structural skeletons and chemical properties.
Chengxian Li +12 more
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Aristolochic acids exposure was not the main cause of liver tumorigenesis in adulthood [PDF]
Acta Pharmaceutica Sinica B, 2022 Aristolochic acids (AAs) have long been considered as a potent carcinogen due to its nephrotoxicity. Aristolochic acid I (AAI) reacts with DNA to form covalent aristolactam (AL)–DNA adducts, leading to subsequent A to T transversion mutation, commonly ...
Shuzhen Chen +21 more
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In situ metabolomics in nephrotoxicity of aristolochic acids based on air flow-assisted desorption electrospray ionization mass spectrometry imaging [PDF]
Acta Pharmaceutica Sinica B, 2020 Understanding of the nephrotoxicity induced by drug candidates is vital to drug discovery and development. Herein, an in situ metabolomics method based on air flow-assisted desorption electrospray ionization mass spectrometry imaging (AFADESI-MSI) was ...
Zhonghua Wang +7 more
doaj +2 more sources
Rapid Analysis of Aristolochic Acid Analogues in Traditional Chinese Patent Medicine by LC-MS/MS
Journal of Analytical Methods in Chemistry, 2020 Aristolochic acids have been demonstrated to have renal toxicity, cause carcinogenesis, and may cause gene mutations. A series of risk control measurements have been adopted worldwide since 1990s.
Jing Liu +4 more
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Review on NMR spectroscopic data and recent analytical methods of aristolochic acids and derivatives in Aristolochia herbs [PDF]
Natural Products and BioprospectingAristolochic acids (AAs) are an important group of secondary metabolites in the genus Aristolochia. The presence of aristolochic acids infers the potency of many Aristolochia herbs used for ages in traditional medicine of China, Europe, Central America ...
Phan Minh Giang +6 more
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