Overview of aristolochic acid nephropathy: an update [PDF]
Kidney Research and Clinical Practice, 2023 Aristolochic acid nephropathy (AAN) is a rapidly progressive renal interstitial fibrosis caused by medical or environmental exposure to aristolochic acid (AA).
Qingqing Zhou +4 more
doaj +4 more sources
Lycopene attenuates the inflammation and apoptosis in aristolochic acid nephropathy by targeting the Nrf2 antioxidant system [PDF]
Redox Biology, 2022 Lycopene (LYC) is a carotenoid, has antioxidant properties. This study investigated whether lycopene attenuates aristolochic acids (AAs) -induced chronic kidney disease.
Yu Wang +8 more
doaj +4 more sources
Beyond Ingestion: Nasal Inhalation-Induced Aristolochic Acid Nephropathy from a Traditional Herbal Remedy – A Case Report [PDF]
Glomerular DiseasesIntroduction: Aristolochic acid nephropathy (AAN), a progressive form of interstitial nephritis, is predominantly associated with the oral ingestion of herbal remedies containing aristolochic acid (AA). Case Presentation: This report details a
Talerngsak Kanjanabuch +4 more
doaj +3 more sources
Experimental Aristolochic Acid Nephropathy: A Relevant Model to Study AKI-to-CKD Transition [PDF]
Frontiers in Medicine, 2022 Aristolochic acid nephropathy (AAN) is a progressive tubulointerstitial nephritis caused by the intake of aristolochic acids (AA) contained in Chinese herbal remedies or contaminated food. AAN is characterized by tubular atrophy and interstitial fibrosis,
Thomas Baudoux +10 more
doaj +4 more sources
Mesenchymal Stem Cell Derived Extracellular Vesicles Ameliorate Kidney Injury in Aristolochic Acid Nephropathy [PDF]
Frontiers in Cell and Developmental Biology, 2020 Limitations in the current therapeutic strategies for the prevention of progression of chronic kidney disease (CKD) to end stage renal disease has been a drawback to improving patient recovery.
Sharad Kholia +16 more
doaj +4 more sources
Interleukin-22 Attenuated Renal Tubular Injury in Aristolochic Acid Nephropathy via Suppressing Activation of NLRP3 Inflammasome [PDF]
Frontiers in Immunology, 2019 Aristolochic acid nephropathy (AAN), as a rapidly progressive interstitial nephropathy due to excessive ingestion of aristolochia herbal medications, has recently raised considerable concerns among clinicians and researchers as its underlying pathogenic ...
Shaofei Wang +17 more
doaj +4 more sources
Tissue xanthine oxidoreductase activity in a mouse model of aristolochic acid nephropathy [PDF]
FEBS Open Bio, 2021 Xanthine oxidoreductase (XOR) is a critical enzyme in purine metabolism and uric acid production, and its levels are reported to increase during stress, thereby promoting organ damage.
Takeo Ishii +13 more
doaj +2 more sources
Integrated single-cell transcriptomics and proteomics reveal cellular-specific responses and microenvironment remodeling in aristolochic acid nephropathy [PDF]
JCI Insight, 2022 Aristolochic acid nephropathy (AAN) is characterized by acute proximal tubule necrosis and immune cell infiltration, contributing to the global burden of chronic kidney disease and urothelial cancer.
Jiayun Chen +10 more
doaj +2 more sources
Arterial Stiffness in Balkan Endemic Nephropathy, an Environmental Form of Aristolochic Acid Nephropathy [PDF]
Frontiers in Cardiovascular Medicine, 2018 Balkan endemic nephropathy (BEN), an environmental form of aristolochic acid nephropathy is characterized with later onset and milder forms of hypertension (HT). Thus, we hypothesized that arterial stiffness progresses slower in BEN patients resulting in
Vedran Premužić +8 more
doaj +2 more sources
Identification and analysis of differently expressed transcription factors in aristolochic acid nephropathy [PDF]
Environmental Health and Preventive MedicineBackground: Aristolochic acid nephropathy (AAN) is a rapidly progressive interstitial nephropathy caused by Aristolochic acid (AA). AAN is associated with the development of nephropathy and urothelial carcinoma. It is estimated that more than 100 million
Yi-Feng Wu +9 more
doaj +2 more sources